Site- and species-specific hydrolysis rates of heroin

The hydroxide-catalyzed non-enzymatic, simultaneous and consecutive hydrolyses of diacetylmorphine (DAM, heroin) are quantified in terms of 10 site- and species-specific rate constants in connection with also 10 site- and species-specific acid-base equilibrium constants, comprising all the 12 coexis...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2016-06, Vol.89, p.105-114
Hauptverfasser:	Szöcs, Levente, Orgován, Gábor, Tóth, Gergő, Kraszni, Márta, Gergó, Lajos, Hosztafi, Sándor, Noszál, Béla
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Ester hydrolysis Heroin Heroin - chemistry Hydrogen-Ion Concentration Hydrolysis Hydroxides - chemistry Microconstant Morphine - chemistry Morphine Derivatives - chemistry Nitrogen - chemistry Protonation Rate constant Solutions - chemistry
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