Are there any additional mechanisms for haemolysis in HELLP syndrome?
Abstract HELLP syndrome is a microangiopathy that leads to severe maternal complications. The objective of this study was to identify any additional mechanisms that could have contributed to HELLP syndrome-induced haemolysis. This is a pilot, prospective and observational study that lasted 9 months....
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| Veröffentlicht in: | Thrombosis research 2016-06, Vol.142, p.40-43 |
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| container_title | Thrombosis research |
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| creator | Sabau, L Terriou, L Provot, F Fourrier, F Roumier, C Caron, C Susen, S Ducloy-Bouthors, A.S |
| description | Abstract HELLP syndrome is a microangiopathy that leads to severe maternal complications. The objective of this study was to identify any additional mechanisms that could have contributed to HELLP syndrome-induced haemolysis. This is a pilot, prospective and observational study that lasted 9 months. All patients with HELLP syndrome treated at academic tertiary care women hospital accepted to participate. Sixteen patients were included. In ten patients (63%), schizocytes were detected following a blood smear test. Six patients (38%) were diagnosed with a partial expression deficiency of proteins regulating the complement system (CD 55 or CD 59). In nine patients (56%), an activation of the complement classical pathway was detected. In two patients (13%), an ADAMTS 13 activity below 30% was detected. Three patients (19%) were diagnosed with a folate deficiency and one (6%) with an antiphospholipid syndrome. All patients developed maternal or fetal morbidity including nine (56%) an acute kidney injury. All patients but one had at least one additional mechanism that could contribute to haemolysis, besides a simple physical injury. Larger studies should be promoted to understand haemolysis in HELLP syndrome. |
| doi_str_mv | 10.1016/j.thromres.2016.03.014 |
| format | Article |
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The objective of this study was to identify any additional mechanisms that could have contributed to HELLP syndrome-induced haemolysis. This is a pilot, prospective and observational study that lasted 9 months. All patients with HELLP syndrome treated at academic tertiary care women hospital accepted to participate. Sixteen patients were included. In ten patients (63%), schizocytes were detected following a blood smear test. Six patients (38%) were diagnosed with a partial expression deficiency of proteins regulating the complement system (CD 55 or CD 59). In nine patients (56%), an activation of the complement classical pathway was detected. In two patients (13%), an ADAMTS 13 activity below 30% was detected. Three patients (19%) were diagnosed with a folate deficiency and one (6%) with an antiphospholipid syndrome. All patients developed maternal or fetal morbidity including nine (56%) an acute kidney injury. All patients but one had at least one additional mechanism that could contribute to haemolysis, besides a simple physical injury. Larger studies should be promoted to understand haemolysis in HELLP syndrome.</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/j.thromres.2016.03.014</identifier><identifier>PMID: 27128171</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Acute kidney injury ; Acute Kidney Injury - etiology ; ADAMTS13 Protein - blood ; Adult ; Antiphospholipid Syndrome - complications ; CD55 Antigens - blood ; CD59 Antigens - blood ; Complement Activation ; Complement system ; Female ; Folic Acid Deficiency - complications ; Haemolysis ; HELLP syndrome ; HELLP Syndrome - blood ; HELLP Syndrome - immunology ; HELLP Syndrome - pathology ; Hematology, Oncology and Palliative Medicine ; Hemolysis ; Humans ; Pilot Projects ; Pregnancy ; Pregnancy Outcome ; Prospective Studies ; Young Adult</subject><ispartof>Thrombosis research, 2016-06, Vol.142, p.40-43</ispartof><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-7ada6767e06255e70ca7b54330b96d807cd4b251f2d8540515dede30852b01383</citedby><cites>FETCH-LOGICAL-c423t-7ada6767e06255e70ca7b54330b96d807cd4b251f2d8540515dede30852b01383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0049384816300743$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27128171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sabau, L</creatorcontrib><creatorcontrib>Terriou, L</creatorcontrib><creatorcontrib>Provot, F</creatorcontrib><creatorcontrib>Fourrier, F</creatorcontrib><creatorcontrib>Roumier, C</creatorcontrib><creatorcontrib>Caron, C</creatorcontrib><creatorcontrib>Susen, S</creatorcontrib><creatorcontrib>Ducloy-Bouthors, A.S</creatorcontrib><title>Are there any additional mechanisms for haemolysis in HELLP syndrome?</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>Abstract HELLP syndrome is a microangiopathy that leads to severe maternal complications. The objective of this study was to identify any additional mechanisms that could have contributed to HELLP syndrome-induced haemolysis. This is a pilot, prospective and observational study that lasted 9 months. All patients with HELLP syndrome treated at academic tertiary care women hospital accepted to participate. Sixteen patients were included. In ten patients (63%), schizocytes were detected following a blood smear test. Six patients (38%) were diagnosed with a partial expression deficiency of proteins regulating the complement system (CD 55 or CD 59). In nine patients (56%), an activation of the complement classical pathway was detected. In two patients (13%), an ADAMTS 13 activity below 30% was detected. Three patients (19%) were diagnosed with a folate deficiency and one (6%) with an antiphospholipid syndrome. All patients developed maternal or fetal morbidity including nine (56%) an acute kidney injury. All patients but one had at least one additional mechanism that could contribute to haemolysis, besides a simple physical injury. Larger studies should be promoted to understand haemolysis in HELLP syndrome.</description><subject>Acute kidney injury</subject><subject>Acute Kidney Injury - etiology</subject><subject>ADAMTS13 Protein - blood</subject><subject>Adult</subject><subject>Antiphospholipid Syndrome - complications</subject><subject>CD55 Antigens - blood</subject><subject>CD59 Antigens - blood</subject><subject>Complement Activation</subject><subject>Complement system</subject><subject>Female</subject><subject>Folic Acid Deficiency - complications</subject><subject>Haemolysis</subject><subject>HELLP syndrome</subject><subject>HELLP Syndrome - blood</subject><subject>HELLP Syndrome - immunology</subject><subject>HELLP Syndrome - pathology</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hemolysis</subject><subject>Humans</subject><subject>Pilot Projects</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Prospective Studies</subject><subject>Young Adult</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1ERbeFv1DlyCVhbMdxcgGqaqFIK7VS4Ww59qzWSxIXT7ZS_j1ebdsDFy4zGumdr-dl7IpDxYE3n_bVvEtxTEiVyHUFsgJev2Er3uquFLUWb9kKoO5K2dbtObsg2gNwzTv1jp0LzUWbixVbXycs5h3maKelsN6HOcTJDsWIbmenQCMV25iKncUxDgsFKsJU3K43m_uClsnnI_DLe3a2tQPhh-d8yX59W_-8uS03d99_3FxvSlcLOZfaetvoRiM0QinU4KzuVS0l9F3jW9DO171QfCt8q2pQXHn0KKFVogcuW3nJPp7mPqb454A0mzGQw2GwE8YDGa47obVQWmdpc5K6FIkSbs1jCqNNi-FgjgjN3rwgNEeEBqTJCHPj1fOOQz-if217YZYFX08CzJ8-BUyGXMDJoQ8J3Wx8DP_f8fmfEW4IU3B2-I0L0j4eUrYg_2NIGDAPRyOPPvJGAugM7C-l0JlZ</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Sabau, L</creator><creator>Terriou, L</creator><creator>Provot, F</creator><creator>Fourrier, F</creator><creator>Roumier, C</creator><creator>Caron, C</creator><creator>Susen, S</creator><creator>Ducloy-Bouthors, A.S</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160601</creationdate><title>Are there any additional mechanisms for haemolysis in HELLP syndrome?</title><author>Sabau, L ; Terriou, L ; Provot, F ; Fourrier, F ; Roumier, C ; Caron, C ; Susen, S ; Ducloy-Bouthors, A.S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-7ada6767e06255e70ca7b54330b96d807cd4b251f2d8540515dede30852b01383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acute kidney injury</topic><topic>Acute Kidney Injury - etiology</topic><topic>ADAMTS13 Protein - blood</topic><topic>Adult</topic><topic>Antiphospholipid Syndrome - complications</topic><topic>CD55 Antigens - blood</topic><topic>CD59 Antigens - blood</topic><topic>Complement Activation</topic><topic>Complement system</topic><topic>Female</topic><topic>Folic Acid Deficiency - complications</topic><topic>Haemolysis</topic><topic>HELLP syndrome</topic><topic>HELLP Syndrome - blood</topic><topic>HELLP Syndrome - immunology</topic><topic>HELLP Syndrome - pathology</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Hemolysis</topic><topic>Humans</topic><topic>Pilot Projects</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Prospective Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sabau, L</creatorcontrib><creatorcontrib>Terriou, L</creatorcontrib><creatorcontrib>Provot, F</creatorcontrib><creatorcontrib>Fourrier, F</creatorcontrib><creatorcontrib>Roumier, C</creatorcontrib><creatorcontrib>Caron, C</creatorcontrib><creatorcontrib>Susen, S</creatorcontrib><creatorcontrib>Ducloy-Bouthors, A.S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sabau, L</au><au>Terriou, L</au><au>Provot, F</au><au>Fourrier, F</au><au>Roumier, C</au><au>Caron, C</au><au>Susen, S</au><au>Ducloy-Bouthors, A.S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are there any additional mechanisms for haemolysis in HELLP syndrome?</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>142</volume><spage>40</spage><epage>43</epage><pages>40-43</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><abstract>Abstract HELLP syndrome is a microangiopathy that leads to severe maternal complications. The objective of this study was to identify any additional mechanisms that could have contributed to HELLP syndrome-induced haemolysis. This is a pilot, prospective and observational study that lasted 9 months. All patients with HELLP syndrome treated at academic tertiary care women hospital accepted to participate. Sixteen patients were included. In ten patients (63%), schizocytes were detected following a blood smear test. Six patients (38%) were diagnosed with a partial expression deficiency of proteins regulating the complement system (CD 55 or CD 59). In nine patients (56%), an activation of the complement classical pathway was detected. In two patients (13%), an ADAMTS 13 activity below 30% was detected. Three patients (19%) were diagnosed with a folate deficiency and one (6%) with an antiphospholipid syndrome. All patients developed maternal or fetal morbidity including nine (56%) an acute kidney injury. All patients but one had at least one additional mechanism that could contribute to haemolysis, besides a simple physical injury. Larger studies should be promoted to understand haemolysis in HELLP syndrome.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>27128171</pmid><doi>10.1016/j.thromres.2016.03.014</doi><tpages>4</tpages></addata></record> |
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| subjects | Acute kidney injury Acute Kidney Injury - etiology ADAMTS13 Protein - blood Adult Antiphospholipid Syndrome - complications CD55 Antigens - blood CD59 Antigens - blood Complement Activation Complement system Female Folic Acid Deficiency - complications Haemolysis HELLP syndrome HELLP Syndrome - blood HELLP Syndrome - immunology HELLP Syndrome - pathology Hematology, Oncology and Palliative Medicine Hemolysis Humans Pilot Projects Pregnancy Pregnancy Outcome Prospective Studies Young Adult |
| title | Are there any additional mechanisms for haemolysis in HELLP syndrome? |
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