The effects of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) on weight gain and hepatic ethoxyresorufin- o-deethylase (EROD) induction vary with ovarian hormonal status in the immature gonadotropin-primed rat model
Immature female rats received 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during an induced proestrus or diestrus. The inhibitory effect of TCDD on acute weight gain and the induction of hepatic ethoxyresorufin-o-deethylase (EROD) activity by TCDD were greatest during proestrus. In a second experimen...
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| Veröffentlicht in: | Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2001-05, Vol.15 (3), p.269-274 |
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| creator | Petroff, Brian K Gao, Xin Rozman, Karl K Terranova, Paul F |
| description | Immature female rats received 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during an induced proestrus or diestrus. The inhibitory effect of TCDD on acute weight gain and the induction of hepatic ethoxyresorufin-o-deethylase (EROD) activity by TCDD were greatest during proestrus. In a second experiment, ovariectomized rats received estradiol cypionate (ECP) or progesterone followed by TCDD. TCDD and estradiol each alone significantly inhibited weight gain. Progesterone potentiated the effects of TCDD on weight gain. The highest dose of ECP was associated with greater induction of hepatic EROD activity by TCDD than seen with TCDD alone. Estradiol modulates the induction of hepatic EROD activity by TCDD. Differential effects of TCDD on acute weight gain during proestrus vs. diestrus in this model do not mimic changes induced by estrogen alone. Hepatic responses to TCDD may vary according to phase of the female reproductive cycle. |
| doi_str_mv | 10.1016/S0890-6238(01)00132-0 |
| format | Article |
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Toxic occupational diseases</subject><subject>Chorionic Gonadotropin - pharmacology</subject><subject>CYP1A1</subject><subject>Cytochrome P-450 CYP1A1 - biosynthesis</subject><subject>Diestrus - drug effects</subject><subject>Dioxin</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Synergism</subject><subject>Environmental Pollutants - toxicity</subject><subject>EROD</subject><subject>Estradiol - analogs & derivatives</subject><subject>Estradiol - blood</subject><subject>Estradiol - pharmacology</subject><subject>Female</subject><subject>Gonadotropins, Equine - pharmacology</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Medical sciences</subject><subject>Models, Animal</subject><subject>Ovariectomy</subject><subject>Ovary</subject><subject>Ovary - drug effects</subject><subject>Ovary - pathology</subject><subject>Ovulation - drug effects</subject><subject>Polychlorinated Dibenzodioxins - toxicity</subject><subject>Proestrus - drug effects</subject><subject>Progesterone - pharmacology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>TCDD</subject><subject>Toxicity</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><subject>Weight Gain - drug effects</subject><issn>0890-6238</issn><issn>1873-1708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd9uFCEUxidGY9fqI2i4MGabLAoDszNzZcy2_kmaNNH1mjBw2MHMwBaYttvn7APJdjfqnVfA4fd9nMNXFK8peU8JXX74QZqW4GXJmjmhZ4RQVmLypJjRpmaY1qR5Wsz-ICfFixh_EUJ43dbPixNKWUtoTWfFw7oHBMaAShF5g8oFW9SLBidIQap-8MFr24G79xhtsbb-zjo0X6_Oz8-Qd-gW7KZPaCNzVTqNetjKZBWC1Pu7XYDow2Ssw8hjDbm4G2QENL_4fpX11ulJJZttbmTYoVubeuTz1kqHeh9G7-SAYpJpiplFKXdqxzEfA6BNvtQ-Bb_N7ttgR9AoyIRGr2F4WTwzcojw6rieFj8_X6xXX_Hl1Zdvq0-XWPGaJVy2S9O0itaSc6Y4a9qqM5UybQsSONedqjlvKqC8UqUu25KVZcXUUsvKaN5Jdlq8O_hug7-eICYx2qhgGKQDP0VB66xpKpbB6gCq4GMMYMS-5Ty0oETs4xSPcYp9VoJQ8RinIFn35vjA1OUJ_6qO-WXg7RGQUcnBBOmUjf-4s7Yq9z4fDxjk37ixEERUFpwCbUNOXmhv_9PJbzepvu4</recordid><startdate>20010501</startdate><enddate>20010501</enddate><creator>Petroff, Brian K</creator><creator>Gao, Xin</creator><creator>Rozman, Karl K</creator><creator>Terranova, Paul F</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20010501</creationdate><title>The effects of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) on weight gain and hepatic ethoxyresorufin- o-deethylase (EROD) induction vary with ovarian hormonal status in the immature gonadotropin-primed rat model</title><author>Petroff, Brian K ; Gao, Xin ; Rozman, Karl K ; Terranova, Paul F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-296f89c17a443c43895bf5cf99eae44dbc74485e145c2d29232253c6da5fd4ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Chorionic Gonadotropin - pharmacology</topic><topic>CYP1A1</topic><topic>Cytochrome P-450 CYP1A1 - biosynthesis</topic><topic>Diestrus - drug effects</topic><topic>Dioxin</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Synergism</topic><topic>Environmental Pollutants - toxicity</topic><topic>EROD</topic><topic>Estradiol - analogs & derivatives</topic><topic>Estradiol - blood</topic><topic>Estradiol - pharmacology</topic><topic>Female</topic><topic>Gonadotropins, Equine - pharmacology</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Medical sciences</topic><topic>Models, Animal</topic><topic>Ovariectomy</topic><topic>Ovary</topic><topic>Ovary - drug effects</topic><topic>Ovary - pathology</topic><topic>Ovulation - drug effects</topic><topic>Polychlorinated Dibenzodioxins - toxicity</topic><topic>Proestrus - drug effects</topic><topic>Progesterone - pharmacology</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>TCDD</topic><topic>Toxicity</topic><topic>Toxicology</topic><topic>Various organic compounds</topic><topic>Weight Gain - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petroff, Brian K</creatorcontrib><creatorcontrib>Gao, Xin</creatorcontrib><creatorcontrib>Rozman, Karl K</creatorcontrib><creatorcontrib>Terranova, Paul F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petroff, Brian K</au><au>Gao, Xin</au><au>Rozman, Karl K</au><au>Terranova, Paul F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) on weight gain and hepatic ethoxyresorufin- o-deethylase (EROD) induction vary with ovarian hormonal status in the immature gonadotropin-primed rat model</atitle><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle><addtitle>Reprod Toxicol</addtitle><date>2001-05-01</date><risdate>2001</risdate><volume>15</volume><issue>3</issue><spage>269</spage><epage>274</epage><pages>269-274</pages><issn>0890-6238</issn><eissn>1873-1708</eissn><abstract>Immature female rats received 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during an induced proestrus or diestrus. The inhibitory effect of TCDD on acute weight gain and the induction of hepatic ethoxyresorufin-o-deethylase (EROD) activity by TCDD were greatest during proestrus. In a second experiment, ovariectomized rats received estradiol cypionate (ECP) or progesterone followed by TCDD. TCDD and estradiol each alone significantly inhibited weight gain. Progesterone potentiated the effects of TCDD on weight gain. The highest dose of ECP was associated with greater induction of hepatic EROD activity by TCDD than seen with TCDD alone. Estradiol modulates the induction of hepatic EROD activity by TCDD. Differential effects of TCDD on acute weight gain during proestrus vs. diestrus in this model do not mimic changes induced by estrogen alone. Hepatic responses to TCDD may vary according to phase of the female reproductive cycle.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11390171</pmid><doi>10.1016/S0890-6238(01)00132-0</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0890-6238 |
| ispartof | Reproductive toxicology (Elmsford, N.Y.), 2001-05, Vol.15 (3), p.269-274 |
| issn | 0890-6238 1873-1708 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Chorionic Gonadotropin - pharmacology CYP1A1 Cytochrome P-450 CYP1A1 - biosynthesis Diestrus - drug effects Dioxin Dose-Response Relationship, Drug Drug Synergism Environmental Pollutants - toxicity EROD Estradiol - analogs & derivatives Estradiol - blood Estradiol - pharmacology Female Gonadotropins, Equine - pharmacology Humans Liver Liver - drug effects Liver - enzymology Medical sciences Models, Animal Ovariectomy Ovary Ovary - drug effects Ovary - pathology Ovulation - drug effects Polychlorinated Dibenzodioxins - toxicity Proestrus - drug effects Progesterone - pharmacology Rat Rats Rats, Sprague-Dawley TCDD Toxicity Toxicology Various organic compounds Weight Gain - drug effects |
| title | The effects of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) on weight gain and hepatic ethoxyresorufin- o-deethylase (EROD) induction vary with ovarian hormonal status in the immature gonadotropin-primed rat model |
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