Defining a new diagnostic assessment parameter for wound care: Elevated protease activity, an indicator of nonhealing, for targeted protease-modulating treatment

ABSTRACT It is widely accepted that elevated protease activity (EPA) in chronic wounds impedes healing. However, little progress has occurred in quantifying the level of protease activity that is detrimental for healing. The aim of this study was to determine the relationship between inflammatory pr...

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Veröffentlicht in:	Wound repair and regeneration 2016-05, Vol.24 (3), p.589-595
Hauptverfasser:	Serena, Thomas E., Cullen, Breda M., Bayliff, Simon W., Gibson, Molly C., Carter, Marissa J., Chen, Lingyun, Yaakov, Raphael A., Samies, John, Sabo, Matthew, DeMarco, Daniel, Le, Namchi, Galbraith, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Area Under Curve Diabetic Foot - diagnosis Diabetic Foot - enzymology Diabetic Foot - physiopathology Diabetic Foot - therapy Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Humans Matrix Metalloproteinases - metabolism Peptide Hydrolases - metabolism Pressure Ulcer - diagnosis Pressure Ulcer - enzymology Pressure Ulcer - physiopathology Pressure Ulcer - therapy ROC Curve Treatment Outcome Varicose Ulcer - enzymology Varicose Ulcer - physiopathology Varicose Ulcer - therapy Wound Healing - drug effects Wounds and Injuries - diagnosis Wounds and Injuries - enzymology Wounds and Injuries - physiopathology Wounds and Injuries - therapy
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