Surveillance of Immunosuppression During Pregnancy After Heart Transplantation: Case Report
Abstract Background Transplantation and immunosuppressive drugs are major limitations to the success of pregnancy. In 1988, the first pregnancy after a heart transplant was reported, which has given female recipients the hope to give birth. During pregnancy, physiologic changes with increased blood...
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| Veröffentlicht in: | Transplantation proceedings 2016-04, Vol.48 (3), p.978-981 |
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| creator | Tsao, C.-I Chou, N.-K Chi, N.-H Huang, S.-C Tsan, C.-Y Wang, C.-H Yu, H.-Y Wu, I.-H Chen, Y.-S Shun, C.-T Wang, S.-S |
| description | Abstract Background Transplantation and immunosuppressive drugs are major limitations to the success of pregnancy. In 1988, the first pregnancy after a heart transplant was reported, which has given female recipients the hope to give birth. During pregnancy, physiologic changes with increased blood volume and hemodilution may influence blood drug level. Case Report We reported our experience in monitoring on immunosuppressive drugs for 2 cases. Both of them underwent heart transplantation in 2006 and were 34 and 37 years old at time of pregnancy. For both cases, we frequently monitored the blood level and increased the dosage of immunosuppressive drugs accordingly. Both cases had uneventful pregnancy and delivery to healthy babies at the National Taiwan University Hospital in Taiwan. Their postpartum courses were uneventful as well. Conclusions We advocate adjusting the immunosuppressive dosage according to the blood level before pregnancy. |
| doi_str_mv | 10.1016/j.transproceed.2016.02.046 |
| format | Article |
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In 1988, the first pregnancy after a heart transplant was reported, which has given female recipients the hope to give birth. During pregnancy, physiologic changes with increased blood volume and hemodilution may influence blood drug level. Case Report We reported our experience in monitoring on immunosuppressive drugs for 2 cases. Both of them underwent heart transplantation in 2006 and were 34 and 37 years old at time of pregnancy. For both cases, we frequently monitored the blood level and increased the dosage of immunosuppressive drugs accordingly. Both cases had uneventful pregnancy and delivery to healthy babies at the National Taiwan University Hospital in Taiwan. Their postpartum courses were uneventful as well. Conclusions We advocate adjusting the immunosuppressive dosage according to the blood level before pregnancy.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2016.02.046</identifier><identifier>PMID: 27234783</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Female ; Graft Rejection - drug therapy ; Heart Transplantation ; Humans ; Immunosuppression - methods ; Immunosuppressive Agents - therapeutic use ; Infant, Newborn ; Pregnancy ; Pregnancy Complications, Cardiovascular ; Pregnancy Outcome ; Surgery</subject><ispartof>Transplantation proceedings, 2016-04, Vol.48 (3), p.978-981</ispartof><rights>2016</rights><rights>Copyright © 2016. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-45d248dbb3e2e555b1dc945a60c51e5a608471f3d95ca3f7a0e5025621cfaddd3</citedby><cites>FETCH-LOGICAL-c435t-45d248dbb3e2e555b1dc945a60c51e5a608471f3d95ca3f7a0e5025621cfaddd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0041134516002864$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27234783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsao, C.-I</creatorcontrib><creatorcontrib>Chou, N.-K</creatorcontrib><creatorcontrib>Chi, N.-H</creatorcontrib><creatorcontrib>Huang, S.-C</creatorcontrib><creatorcontrib>Tsan, C.-Y</creatorcontrib><creatorcontrib>Wang, C.-H</creatorcontrib><creatorcontrib>Yu, H.-Y</creatorcontrib><creatorcontrib>Wu, I.-H</creatorcontrib><creatorcontrib>Chen, Y.-S</creatorcontrib><creatorcontrib>Shun, C.-T</creatorcontrib><creatorcontrib>Wang, S.-S</creatorcontrib><title>Surveillance of Immunosuppression During Pregnancy After Heart Transplantation: Case Report</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract Background Transplantation and immunosuppressive drugs are major limitations to the success of pregnancy. In 1988, the first pregnancy after a heart transplant was reported, which has given female recipients the hope to give birth. During pregnancy, physiologic changes with increased blood volume and hemodilution may influence blood drug level. Case Report We reported our experience in monitoring on immunosuppressive drugs for 2 cases. Both of them underwent heart transplantation in 2006 and were 34 and 37 years old at time of pregnancy. For both cases, we frequently monitored the blood level and increased the dosage of immunosuppressive drugs accordingly. Both cases had uneventful pregnancy and delivery to healthy babies at the National Taiwan University Hospital in Taiwan. Their postpartum courses were uneventful as well. Conclusions We advocate adjusting the immunosuppressive dosage according to the blood level before pregnancy.</description><subject>Adult</subject><subject>Female</subject><subject>Graft Rejection - drug therapy</subject><subject>Heart Transplantation</subject><subject>Humans</subject><subject>Immunosuppression - methods</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Infant, Newborn</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Cardiovascular</subject><subject>Pregnancy Outcome</subject><subject>Surgery</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1P3DAQhi0EKlvav4Csnrgk9WeS5YCEFihISCCgpx4srz1B3iZxsB2k_fc4XZCqnnoazfh9ZzzPIPSNkpISWn3flCnoIY7BGwBbslwrCSuJqPbQgjY1L1jF-D5aECJoQbmQh-hzjBuScyb4J3TIasZF3fAF-vU4hVdwXacHA9i3-Kbvp8HHaRwDxOj8gC-m4IZnfB_geciqLT5vEwR8DTok_PTnJ9mddMriU7zSEfADjD6kL-ig1V2Er-_xCP28unxaXRe3dz9uVue3hRFcpkJIy0Rj12sODKSUa2rNUkhdESMpzLERNW25XUqjeVtrApIwWTFqWm2t5UfoZNc3E3mZICbVu2hg3gn8FBWtl4zXpJEiS093UhN8jAFaNQbX67BVlKgZrtqov-GqGa4iTGW42Xz8Pmda9_ntw_pBMwsudgLI2746CCoaBxmsdQFMUta7_5tz9k8b07nBGd39hi3EjZ_CkHkqqmI2qMf5zPOVaUUIayrB3wBHr6hq</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Tsao, C.-I</creator><creator>Chou, N.-K</creator><creator>Chi, N.-H</creator><creator>Huang, S.-C</creator><creator>Tsan, C.-Y</creator><creator>Wang, C.-H</creator><creator>Yu, H.-Y</creator><creator>Wu, I.-H</creator><creator>Chen, Y.-S</creator><creator>Shun, C.-T</creator><creator>Wang, S.-S</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160401</creationdate><title>Surveillance of Immunosuppression During Pregnancy After Heart Transplantation: Case Report</title><author>Tsao, C.-I ; Chou, N.-K ; Chi, N.-H ; Huang, S.-C ; Tsan, C.-Y ; Wang, C.-H ; Yu, H.-Y ; Wu, I.-H ; Chen, Y.-S ; Shun, C.-T ; Wang, S.-S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-45d248dbb3e2e555b1dc945a60c51e5a608471f3d95ca3f7a0e5025621cfaddd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Female</topic><topic>Graft Rejection - drug therapy</topic><topic>Heart Transplantation</topic><topic>Humans</topic><topic>Immunosuppression - methods</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Infant, Newborn</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Cardiovascular</topic><topic>Pregnancy Outcome</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsao, C.-I</creatorcontrib><creatorcontrib>Chou, N.-K</creatorcontrib><creatorcontrib>Chi, N.-H</creatorcontrib><creatorcontrib>Huang, S.-C</creatorcontrib><creatorcontrib>Tsan, C.-Y</creatorcontrib><creatorcontrib>Wang, C.-H</creatorcontrib><creatorcontrib>Yu, H.-Y</creatorcontrib><creatorcontrib>Wu, I.-H</creatorcontrib><creatorcontrib>Chen, Y.-S</creatorcontrib><creatorcontrib>Shun, C.-T</creatorcontrib><creatorcontrib>Wang, S.-S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsao, C.-I</au><au>Chou, N.-K</au><au>Chi, N.-H</au><au>Huang, S.-C</au><au>Tsan, C.-Y</au><au>Wang, C.-H</au><au>Yu, H.-Y</au><au>Wu, I.-H</au><au>Chen, Y.-S</au><au>Shun, C.-T</au><au>Wang, S.-S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surveillance of Immunosuppression During Pregnancy After Heart Transplantation: Case Report</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>48</volume><issue>3</issue><spage>978</spage><epage>981</epage><pages>978-981</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><abstract>Abstract Background Transplantation and immunosuppressive drugs are major limitations to the success of pregnancy. In 1988, the first pregnancy after a heart transplant was reported, which has given female recipients the hope to give birth. During pregnancy, physiologic changes with increased blood volume and hemodilution may influence blood drug level. Case Report We reported our experience in monitoring on immunosuppressive drugs for 2 cases. Both of them underwent heart transplantation in 2006 and were 34 and 37 years old at time of pregnancy. For both cases, we frequently monitored the blood level and increased the dosage of immunosuppressive drugs accordingly. Both cases had uneventful pregnancy and delivery to healthy babies at the National Taiwan University Hospital in Taiwan. Their postpartum courses were uneventful as well. Conclusions We advocate adjusting the immunosuppressive dosage according to the blood level before pregnancy.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27234783</pmid><doi>10.1016/j.transproceed.2016.02.046</doi><tpages>4</tpages></addata></record> |
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| ispartof | Transplantation proceedings, 2016-04, Vol.48 (3), p.978-981 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Female Graft Rejection - drug therapy Heart Transplantation Humans Immunosuppression - methods Immunosuppressive Agents - therapeutic use Infant, Newborn Pregnancy Pregnancy Complications, Cardiovascular Pregnancy Outcome Surgery |
| title | Surveillance of Immunosuppression During Pregnancy After Heart Transplantation: Case Report |
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