Anti-arthritic activity of 11-O-(4′-O-methyl galloyl)-bergenin and Crassula capitella extract in rats

Objectives Isolation and identification of phytochemicals of Crassula capitella (Thunberg), evaluation of the anti‐arthritic potential of the extract and the major isolated compound; 11‐O‐(4′‐O‐methyl galloyl)‐bergenin and underlying their mechanism on rat model of rheumatoid arthritis (RA). Methods...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2016-06, Vol.68 (6), p.834-844
Hauptverfasser:	El-Hawary, Seham S., Mohammed, Rabab, Abouzid, Sameh, Ali, Zeinab Y., Elwekeel, Ahlam
Format:	Artikel
Sprache:	eng
Schlagworte:	11-O-(4′-O-methyl galloyl)-bergenin Animals Arthritis, Experimental - blood Arthritis, Experimental - chemically induced Arthritis, Experimental - pathology Arthritis, Experimental - prevention & control Benzopyrans - isolation & purification Benzopyrans - pharmacology Biomarkers - blood Bone and Bones - drug effects Bone and Bones - enzymology Carbon-13 Magnetic Resonance Spectroscopy Cartilage, Articular - drug effects Cartilage, Articular - enzymology Chromatography, High Pressure Liquid Crassula capitella Crassulaceae - chemistry Cytokines - blood Disease Progression Egypt Female Freund's Adjuvant Gallic Acid - analogs & derivatives Gallic Acid - isolation & purification Gallic Acid - pharmacology Inflammation Mediators - blood Joints - drug effects Joints - enzymology Joints - pathology lysosomal enzymes Mass Spectrometry Oxidative Stress - drug effects Phytotherapy Plant Components, Aerial Plant Extracts - isolation & purification Plant Extracts - pharmacology Plants, Medicinal pro-inflammatory mediators Proton Magnetic Resonance Spectroscopy Rats, Sprague-Dawley rheumatoid arthritis Severity of Illness Index Time Factors Weight Gain
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