Negative regulation of the Wnt-s-catenin pathway by the transcriptional repressor HBP1

In certain cancers, constitutive Wnt signaling results from mutation in one or more pathway components. The result is the accumulation and nuclear localization of s-catenin, which interacts with the lymphoid enhancer factor-1 (LEF)/T-cell factor (TCF) family of HMG-box transcription factors, which a...

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Veröffentlicht in:	The EMBO journal 2001-08, Vol.20 (16), p.4500-4511
Hauptverfasser:	Sampson, E M, Haque, Z K, Ku, M, Tevosian, S G, Albanese, C, Pestell, R G, Paulson, KE, Yee, A S
Format:	Artikel
Sprache:	eng
Schlagworte:	lymphoid enhancer factor-1 s-catenin
Online-Zugang:	Volltext
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