Involvement of p38 MAP Kinase Pathway in the Synergistic Activation of PACAP mRNA Expression by NGF and PACAP in PC12h Cells

We have recently shown that in PC12 cells, PACAP and NGF synergistically increase PACAP gene transcription and mRNA level, and that the MAPK/ERK kinase inhibitor PD98059 blocks the PACAP mRNA expression induced by either PACAP or NGF, but not that induced by the combination, suggesting involvement o...

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Veröffentlicht in:	Biochemical and biophysical research communications 2001-07, Vol.285 (3), p.656-661
Hauptverfasser:	Sakai, Yoshiyuki, Hashimoto, Hitoshi, Shintani, Norihito, Tomimoto, Shuhei, Tanaka, Kazuhiro, Ichibori, Ayako, Hirose, Megumi, Baba, Akemichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dose-Response Relationship, Drug Drug Synergism Enzyme Inhibitors - pharmacology ERK kinase (MEK) ERK protein Flavonoids - pharmacology Gene Expression - drug effects Imidazoles - pharmacology mitogen-activated protein (MAP) kinase Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism nerve growth factor (NGF) Nerve Growth Factor - pharmacology neurite outgrowth Neurites - drug effects Neuropeptides - genetics Neuropeptides - metabolism Neuropeptides - pharmacology p38 MAP kinase p38 Mitogen-Activated Protein Kinases PC12 Cells PC12h cell PD98059 Pituitary Adenylate Cyclase-Activating Polypeptide pituitary adenylate cyclase-activating polypeptide (PACAP) Pyridines - pharmacology Rats RNA, Messenger - biosynthesis SB203580 Signal Transduction - drug effects Signal Transduction - physiology
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