Roles of the Proline-rich Domain in SLP-76 Subcellular Localization and T Cell Function[boxs]

The adaptor protein Src homology (SH)2 domain-containing and leukocyte-specific phosphoprotein of 76 kDa (SLP-76) is critical for signal transduction in multiple hematopoietic lineages. It links proximal and distal T cell receptor signaling events through its function as a molecular scaffold in the...

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Veröffentlicht in:	The Journal of biological chemistry 2004-04, Vol.279 (15), p.15481-15490
Hauptverfasser:	Singer, Andrew L., Bunnell, Stephen C., Obstfeld, Amrom E., Jordan, Martha S., Wu, Jennifer N., Myung, Peggy S., Samelson, Lawrence E., Koretzky, Gary A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Alanine - chemistry Antigens, CD - biosynthesis Antigens, Differentiation, T-Lymphocyte - biosynthesis Arginine - chemistry Blotting, Western Calcium - metabolism Cell Line Cell Lineage Flow Cytometry Gene Deletion Genes, Dominant Hematopoietic Stem Cells - metabolism Humans Jurkat Cells Lectins, C-Type Luciferases - metabolism Lymphocyte Activation Lysine - chemistry Membrane Microdomains - metabolism Models, Biological Mutation Phosphoproteins - chemistry Phosphoproteins - metabolism Plasmids - metabolism Precipitin Tests Proline - chemistry Protein Structure, Tertiary Signal Transduction src Homology Domains Subcellular Fractions - metabolism T-Lymphocytes - metabolism Time Factors Transfection
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