Hepatitis B virus genotypes and evolutionary markers in chronic HBsAG patients in Bujumbura
Hepatitis B virus infection (VHB) is a serious condition which can lead to serious complications, such as cirrhosis and hepato-cellular carcinoma (HCC). HBV genotypes greatly influence its evolution and the effectiveness of treatment. The aim was to evaluate the HBV genotypes and the evolutionary pa...
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| Veröffentlicht in: | The Pan African medical journal 2016, Vol.23, p.95-95 |
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| creator | Ntagirabiri, Rénovat Munezero, Belyse Nahimana, Caritas Ndabaneze, Evariste |
| description | Hepatitis B virus infection (VHB) is a serious condition which can lead to serious complications, such as cirrhosis and hepato-cellular carcinoma (HCC). HBV genotypes greatly influence its evolution and the effectiveness of treatment. The aim was to evaluate the HBV genotypes and the evolutionary pathways of chronic HBsAG patients.
A cross-sectional study was conducted at the University Hospital of Kamenge and at the Digestive and liver diseases Center "CEMADIF" between June 2013 and Mai 2014. Genotyping, quantitative assay of HBeAG and HBV DNA levels were determined in the CERBA Laboratory Cergy Pontoise, France. Fibrotest or Fibroscan were used to evaluate fibrosis.
In total 33 patients (52,4% were males, median age 38,1) were enrolled. According to evolutionary markers, 112 patients (78,3%) had negative HBeAG. As regards the viral load, 106 patients (74,2%) had viremia lower than 2000UI/ml and minimal fibrosis below 7 kPa according FibroScan. Of these, 13 patients had undetectable HBV DNA (0,8UI/ml). It was possible to determine genotype in 51 patients who had a high enough viremia to technically enable dosing. These patients had genotype A.
HBV genotype-A is the most common in Bujumbura. It is associated with HBV inactive carries. |
| doi_str_mv | 10.11604/pamj.2016.23.95.8424 |
| format | Article |
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A cross-sectional study was conducted at the University Hospital of Kamenge and at the Digestive and liver diseases Center "CEMADIF" between June 2013 and Mai 2014. Genotyping, quantitative assay of HBeAG and HBV DNA levels were determined in the CERBA Laboratory Cergy Pontoise, France. Fibrotest or Fibroscan were used to evaluate fibrosis.
In total 33 patients (52,4% were males, median age 38,1) were enrolled. According to evolutionary markers, 112 patients (78,3%) had negative HBeAG. As regards the viral load, 106 patients (74,2%) had viremia lower than 2000UI/ml and minimal fibrosis below 7 kPa according FibroScan. Of these, 13 patients had undetectable HBV DNA (<20UI/ml). The others 37 patients (26,8%) had a viral load higher than 2000UI/ml and, among them, 31 were HBeAg positive(>0,8UI/ml). It was possible to determine genotype in 51 patients who had a high enough viremia to technically enable dosing. These patients had genotype A.
HBV genotype-A is the most common in Bujumbura. It is associated with HBV inactive carries.</description><identifier>EISSN: 1937-8688</identifier><identifier>DOI: 10.11604/pamj.2016.23.95.8424</identifier><identifier>PMID: 27222687</identifier><language>fre</language><publisher>Uganda</publisher><subject>Adult ; Burundi - epidemiology ; Cross-Sectional Studies ; DNA, Viral ; Female ; Genotype ; Hepatitis B e Antigens - genetics ; Hepatitis B Surface Antigens - genetics ; Hepatitis B virus - genetics ; Hepatitis B, Chronic - epidemiology ; Hepatitis B, Chronic - virology ; Humans ; Male ; Viral Load ; Viremia - virology</subject><ispartof>The Pan African medical journal, 2016, Vol.23, p.95-95</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,4014,27914,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27222687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ntagirabiri, Rénovat</creatorcontrib><creatorcontrib>Munezero, Belyse</creatorcontrib><creatorcontrib>Nahimana, Caritas</creatorcontrib><creatorcontrib>Ndabaneze, Evariste</creatorcontrib><title>Hepatitis B virus genotypes and evolutionary markers in chronic HBsAG patients in Bujumbura</title><title>The Pan African medical journal</title><addtitle>Pan Afr Med J</addtitle><description>Hepatitis B virus infection (VHB) is a serious condition which can lead to serious complications, such as cirrhosis and hepato-cellular carcinoma (HCC). HBV genotypes greatly influence its evolution and the effectiveness of treatment. The aim was to evaluate the HBV genotypes and the evolutionary pathways of chronic HBsAG patients.
A cross-sectional study was conducted at the University Hospital of Kamenge and at the Digestive and liver diseases Center "CEMADIF" between June 2013 and Mai 2014. Genotyping, quantitative assay of HBeAG and HBV DNA levels were determined in the CERBA Laboratory Cergy Pontoise, France. Fibrotest or Fibroscan were used to evaluate fibrosis.
In total 33 patients (52,4% were males, median age 38,1) were enrolled. According to evolutionary markers, 112 patients (78,3%) had negative HBeAG. As regards the viral load, 106 patients (74,2%) had viremia lower than 2000UI/ml and minimal fibrosis below 7 kPa according FibroScan. Of these, 13 patients had undetectable HBV DNA (<20UI/ml). The others 37 patients (26,8%) had a viral load higher than 2000UI/ml and, among them, 31 were HBeAg positive(>0,8UI/ml). It was possible to determine genotype in 51 patients who had a high enough viremia to technically enable dosing. These patients had genotype A.
HBV genotype-A is the most common in Bujumbura. It is associated with HBV inactive carries.</description><subject>Adult</subject><subject>Burundi - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>DNA, Viral</subject><subject>Female</subject><subject>Genotype</subject><subject>Hepatitis B e Antigens - genetics</subject><subject>Hepatitis B Surface Antigens - genetics</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B, Chronic - epidemiology</subject><subject>Hepatitis B, Chronic - virology</subject><subject>Humans</subject><subject>Male</subject><subject>Viral Load</subject><subject>Viremia - virology</subject><issn>1937-8688</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kDtPwzAYRS0kREvhJ4A8sjT4FT_GtoIWqRILTAyR43wBl7yw40r99xQo0x3u0ZHuReiGkoxSScT9YNtdxgiVGeOZyTMtmDhDU2q4mmup9QRdxrgjRErNyQWaMMUYk1pN0dsGBjv60Ue8xHsfUsTv0PXjYYCIbVdh2PdNGn3f2XDArQ2fECL2HXYfoe-8w5tlXKzxjwO68bdZpl1qyxTsFTqvbRPh-pQz9Pr48LLazLfP66fVYjsfqKDjXJaagRbEcVVbkzvDDNQlz5URosyNIIrosnJCABe54M5UOXU1IZWSRCsCfIbu_rxD6L8SxLFofXTQNLaDPsWCKkMVp9zkR_T2hKayhaoYgj9uOhT_h_BvacpiHA</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Ntagirabiri, Rénovat</creator><creator>Munezero, Belyse</creator><creator>Nahimana, Caritas</creator><creator>Ndabaneze, Evariste</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2016</creationdate><title>Hepatitis B virus genotypes and evolutionary markers in chronic HBsAG patients in Bujumbura</title><author>Ntagirabiri, Rénovat ; Munezero, Belyse ; Nahimana, Caritas ; Ndabaneze, Evariste</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p141t-6b82e840c37fa95c929efb357944b5940708bdc44e34543c9d51cf00d760870e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Burundi - epidemiology</topic><topic>Cross-Sectional Studies</topic><topic>DNA, Viral</topic><topic>Female</topic><topic>Genotype</topic><topic>Hepatitis B e Antigens - genetics</topic><topic>Hepatitis B Surface Antigens - genetics</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B, Chronic - epidemiology</topic><topic>Hepatitis B, Chronic - virology</topic><topic>Humans</topic><topic>Male</topic><topic>Viral Load</topic><topic>Viremia - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ntagirabiri, Rénovat</creatorcontrib><creatorcontrib>Munezero, Belyse</creatorcontrib><creatorcontrib>Nahimana, Caritas</creatorcontrib><creatorcontrib>Ndabaneze, Evariste</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Pan African medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ntagirabiri, Rénovat</au><au>Munezero, Belyse</au><au>Nahimana, Caritas</au><au>Ndabaneze, Evariste</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis B virus genotypes and evolutionary markers in chronic HBsAG patients in Bujumbura</atitle><jtitle>The Pan African medical journal</jtitle><addtitle>Pan Afr Med J</addtitle><date>2016</date><risdate>2016</risdate><volume>23</volume><spage>95</spage><epage>95</epage><pages>95-95</pages><eissn>1937-8688</eissn><abstract>Hepatitis B virus infection (VHB) is a serious condition which can lead to serious complications, such as cirrhosis and hepato-cellular carcinoma (HCC). HBV genotypes greatly influence its evolution and the effectiveness of treatment. The aim was to evaluate the HBV genotypes and the evolutionary pathways of chronic HBsAG patients.
A cross-sectional study was conducted at the University Hospital of Kamenge and at the Digestive and liver diseases Center "CEMADIF" between June 2013 and Mai 2014. Genotyping, quantitative assay of HBeAG and HBV DNA levels were determined in the CERBA Laboratory Cergy Pontoise, France. Fibrotest or Fibroscan were used to evaluate fibrosis.
In total 33 patients (52,4% were males, median age 38,1) were enrolled. According to evolutionary markers, 112 patients (78,3%) had negative HBeAG. As regards the viral load, 106 patients (74,2%) had viremia lower than 2000UI/ml and minimal fibrosis below 7 kPa according FibroScan. Of these, 13 patients had undetectable HBV DNA (<20UI/ml). The others 37 patients (26,8%) had a viral load higher than 2000UI/ml and, among them, 31 were HBeAg positive(>0,8UI/ml). It was possible to determine genotype in 51 patients who had a high enough viremia to technically enable dosing. These patients had genotype A.
HBV genotype-A is the most common in Bujumbura. It is associated with HBV inactive carries.</abstract><cop>Uganda</cop><pmid>27222687</pmid><doi>10.11604/pamj.2016.23.95.8424</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | African Journals Online (Open Access); MEDLINE; PubMed Central (PMC); Directory of Open Access Journals; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Adult Burundi - epidemiology Cross-Sectional Studies DNA, Viral Female Genotype Hepatitis B e Antigens - genetics Hepatitis B Surface Antigens - genetics Hepatitis B virus - genetics Hepatitis B, Chronic - epidemiology Hepatitis B, Chronic - virology Humans Male Viral Load Viremia - virology |
| title | Hepatitis B virus genotypes and evolutionary markers in chronic HBsAG patients in Bujumbura |
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