Persistent suppression of contact hypersensitivity, and altered T-cell parameters in F344 rats exposed perinatally to 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD)

The outcome of perinatal low-level TCDD exposure on the T-cell-mediated contact hypersensitivity (CHS) response in adult F344 rats was investigated. Suppression of the 2,4-dinitrofluorobenzene (DNFB)-specific contact hypersensitivity reponse occurred in mature offspring of dams dosed by gavage with...

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Veröffentlicht in:	Toxicology (Amsterdam) 2004-04, Vol.197 (1), p.57-66
Hauptverfasser:	Walker, Dana B, Williams, Wanda C, Copeland, Cary B, Smialowicz, Ralph J
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3,7,8-Tetrachlorodibenzo- p-dioxin Administration, Oral Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Contact hypersensitivity Developmental immunotoxicity Environmental Pollutants - administration & dosage Environmental Pollutants - toxicity Female Fetus - abnormalities Fetus - drug effects Flow Cytometry Hypersensitivity, Delayed - chemically induced Hypersensitivity, Delayed - pathology Hypersensitivity, Delayed - prevention & control Leukocyte Common Antigens - metabolism Lymph Nodes - drug effects Lymph Nodes - pathology Male Maternal Exposure Medical sciences Polychlorinated Dibenzodioxins - administration & dosage Polychlorinated Dibenzodioxins - toxicity Pregnancy Prenatal Exposure Delayed Effects Rats Rats, Inbred F344 T cell T lymphocyte T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - pathology TCDD Toxicology Various organic compounds
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