Telocytes (interstitial Cajal-like cells) in human Fallopian tubes
Telocytes represent a relatively newly discovered population of cells found within the various tissues and organs, including Fallopian tubes. It is presumed that telocytes could serve as a sensor of hormone levels or regulate activity of muscle peristaltic movement. Tissue sections from anatomically...
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| Veröffentlicht in: | Bratislava Medical Journal 2016, Vol.117 (5), p.263-267 |
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| creator | Urban, L Miko, M Kajanova, M Bozikova, S Mrazova, H Varga, I |
| description | Telocytes represent a relatively newly discovered population of cells found within the various tissues and organs, including Fallopian tubes. It is presumed that telocytes could serve as a sensor of hormone levels or regulate activity of muscle peristaltic movement.
Tissue sections from anatomically different parts of Fallopian tubes of 48 women (age 48.8±9.1) were stained for the expression of five different antigens: c-kit (CD117), CD34, vimentin, podoplanin (D2-40) and Dog-1.
Telocytes form a network associated with the smooth muscle cells. From the mentioned antibodies, only anti-c-kit (CD117) seems to be relatively selective specific to the telocytes, others react also with numerous other cells and tissue structures. Our results when using antibodies against podoplanin and Dog-1 are in dissonance with recent literature - with regards to our results, they are not suitable for detection of telocytes.
Methods of immunohistochemistry are suitable for identification of telocytes in Fallopian tubes. C-kit (CD117) antigens are useful for routine identification of telocytes in histological sections. This antigen can be combined with CD34 or vimentin in cases of double staining immunohistochemistry. |
| doi_str_mv | 10.4149/BLL_2016_051 |
| format | Article |
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Tissue sections from anatomically different parts of Fallopian tubes of 48 women (age 48.8±9.1) were stained for the expression of five different antigens: c-kit (CD117), CD34, vimentin, podoplanin (D2-40) and Dog-1.
Telocytes form a network associated with the smooth muscle cells. From the mentioned antibodies, only anti-c-kit (CD117) seems to be relatively selective specific to the telocytes, others react also with numerous other cells and tissue structures. Our results when using antibodies against podoplanin and Dog-1 are in dissonance with recent literature - with regards to our results, they are not suitable for detection of telocytes.
Methods of immunohistochemistry are suitable for identification of telocytes in Fallopian tubes. C-kit (CD117) antigens are useful for routine identification of telocytes in histological sections. This antigen can be combined with CD34 or vimentin in cases of double staining immunohistochemistry.</description><identifier>ISSN: 0006-9248</identifier><identifier>ISSN: 1336-0345</identifier><identifier>EISSN: 1336-0345</identifier><identifier>DOI: 10.4149/BLL_2016_051</identifier><identifier>PMID: 27215957</identifier><language>eng</language><publisher>Slovakia</publisher><subject>Adult ; Anoctamin-1 ; Antigens, CD34 - metabolism ; Chloride Channels - metabolism ; Fallopian Tubes - cytology ; Fallopian Tubes - metabolism ; Female ; Humans ; Immunohistochemistry ; Membrane Glycoproteins - metabolism ; Middle Aged ; Neoplasm Proteins - metabolism ; Proto-Oncogene Proteins c-kit - metabolism ; Telocytes - cytology ; Telocytes - metabolism ; Vimentin - metabolism</subject><ispartof>Bratislava Medical Journal, 2016, Vol.117 (5), p.263-267</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-51843c536fb7fd76dde6617b5456b1337ae1bf20235f7b61d572438159839f0a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27215957$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Urban, L</creatorcontrib><creatorcontrib>Miko, M</creatorcontrib><creatorcontrib>Kajanova, M</creatorcontrib><creatorcontrib>Bozikova, S</creatorcontrib><creatorcontrib>Mrazova, H</creatorcontrib><creatorcontrib>Varga, I</creatorcontrib><title>Telocytes (interstitial Cajal-like cells) in human Fallopian tubes</title><title>Bratislava Medical Journal</title><addtitle>Bratisl Lek Listy</addtitle><description>Telocytes represent a relatively newly discovered population of cells found within the various tissues and organs, including Fallopian tubes. It is presumed that telocytes could serve as a sensor of hormone levels or regulate activity of muscle peristaltic movement.
Tissue sections from anatomically different parts of Fallopian tubes of 48 women (age 48.8±9.1) were stained for the expression of five different antigens: c-kit (CD117), CD34, vimentin, podoplanin (D2-40) and Dog-1.
Telocytes form a network associated with the smooth muscle cells. From the mentioned antibodies, only anti-c-kit (CD117) seems to be relatively selective specific to the telocytes, others react also with numerous other cells and tissue structures. Our results when using antibodies against podoplanin and Dog-1 are in dissonance with recent literature - with regards to our results, they are not suitable for detection of telocytes.
Methods of immunohistochemistry are suitable for identification of telocytes in Fallopian tubes. C-kit (CD117) antigens are useful for routine identification of telocytes in histological sections. This antigen can be combined with CD34 or vimentin in cases of double staining immunohistochemistry.</description><subject>Adult</subject><subject>Anoctamin-1</subject><subject>Antigens, CD34 - metabolism</subject><subject>Chloride Channels - metabolism</subject><subject>Fallopian Tubes - cytology</subject><subject>Fallopian Tubes - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Proto-Oncogene Proteins c-kit - metabolism</subject><subject>Telocytes - cytology</subject><subject>Telocytes - metabolism</subject><subject>Vimentin - metabolism</subject><issn>0006-9248</issn><issn>1336-0345</issn><issn>1336-0345</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1LwzAYh4Mobk5vnqXHCVbznebohlOh4GWeQ9ImmJm2s0kP--_XsSme3vfw8PDwA-AWwUeKqHxalKXCEHEFGToDU0QIzyGh7BxMIYQ8l5gWE3AV4wZCShjil2CCBUZMMjEFi7UNXbVLNmZz3ybbx-ST1yFb6o0OefDfNqtsCPE-8232NTS6zVY6hG7rxy8NxsZrcOF0iPbmdGfgc_WyXr7l5cfr-_K5zCsiZcoZKiipGOHOCFcLXteWcyQMo4ybsVpoi4zDEBPmhOGoZgJTUoydBZEOajID86N323c_g41JNT4e2nRruyEqJOSowQXiI_pwRKu-i7G3Tm173-h-pxBUh9XU_9VG_O5kHkxj6z_4dyayB3JuZfM</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Urban, L</creator><creator>Miko, M</creator><creator>Kajanova, M</creator><creator>Bozikova, S</creator><creator>Mrazova, H</creator><creator>Varga, I</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2016</creationdate><title>Telocytes (interstitial Cajal-like cells) in human Fallopian tubes</title><author>Urban, L ; Miko, M ; Kajanova, M ; Bozikova, S ; Mrazova, H ; Varga, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-51843c536fb7fd76dde6617b5456b1337ae1bf20235f7b61d572438159839f0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Anoctamin-1</topic><topic>Antigens, CD34 - metabolism</topic><topic>Chloride Channels - metabolism</topic><topic>Fallopian Tubes - cytology</topic><topic>Fallopian Tubes - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Proto-Oncogene Proteins c-kit - metabolism</topic><topic>Telocytes - cytology</topic><topic>Telocytes - metabolism</topic><topic>Vimentin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Urban, L</creatorcontrib><creatorcontrib>Miko, M</creatorcontrib><creatorcontrib>Kajanova, M</creatorcontrib><creatorcontrib>Bozikova, S</creatorcontrib><creatorcontrib>Mrazova, H</creatorcontrib><creatorcontrib>Varga, I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bratislava Medical Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Urban, L</au><au>Miko, M</au><au>Kajanova, M</au><au>Bozikova, S</au><au>Mrazova, H</au><au>Varga, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Telocytes (interstitial Cajal-like cells) in human Fallopian tubes</atitle><jtitle>Bratislava Medical Journal</jtitle><addtitle>Bratisl Lek Listy</addtitle><date>2016</date><risdate>2016</risdate><volume>117</volume><issue>5</issue><spage>263</spage><epage>267</epage><pages>263-267</pages><issn>0006-9248</issn><issn>1336-0345</issn><eissn>1336-0345</eissn><abstract>Telocytes represent a relatively newly discovered population of cells found within the various tissues and organs, including Fallopian tubes. It is presumed that telocytes could serve as a sensor of hormone levels or regulate activity of muscle peristaltic movement.
Tissue sections from anatomically different parts of Fallopian tubes of 48 women (age 48.8±9.1) were stained for the expression of five different antigens: c-kit (CD117), CD34, vimentin, podoplanin (D2-40) and Dog-1.
Telocytes form a network associated with the smooth muscle cells. From the mentioned antibodies, only anti-c-kit (CD117) seems to be relatively selective specific to the telocytes, others react also with numerous other cells and tissue structures. Our results when using antibodies against podoplanin and Dog-1 are in dissonance with recent literature - with regards to our results, they are not suitable for detection of telocytes.
Methods of immunohistochemistry are suitable for identification of telocytes in Fallopian tubes. C-kit (CD117) antigens are useful for routine identification of telocytes in histological sections. This antigen can be combined with CD34 or vimentin in cases of double staining immunohistochemistry.</abstract><cop>Slovakia</cop><pmid>27215957</pmid><doi>10.4149/BLL_2016_051</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Anoctamin-1 Antigens, CD34 - metabolism Chloride Channels - metabolism Fallopian Tubes - cytology Fallopian Tubes - metabolism Female Humans Immunohistochemistry Membrane Glycoproteins - metabolism Middle Aged Neoplasm Proteins - metabolism Proto-Oncogene Proteins c-kit - metabolism Telocytes - cytology Telocytes - metabolism Vimentin - metabolism |
| title | Telocytes (interstitial Cajal-like cells) in human Fallopian tubes |
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