Computational simulation and comparison of prothrombin complex concentrate dosing schemes for warfarin reversal in cardiac surgery

Background Prothrombin complex concentrate (PCC) is increasingly used for acute warfarin reversal. We hypothesized that computational modeling of thrombin generation (TG) could be used to optimize the timing and dose of PCC during hemodilution induced by cardiopulmonary bypass (CPB). Methods Thrombi...

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Veröffentlicht in:	Journal of anesthesia 2016-06, Vol.30 (3), p.369-376
Hauptverfasser:	Tanaka, Kenichi A., Mazzeffi, Michael A., Strauss, Erik R., Szlam, Fania, Guzzetta, Nina A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesiology Anticoagulants - adverse effects Blood Coagulation - drug effects Blood Coagulation Factors - administration & dosage Cardiac Surgical Procedures - methods Cardiopulmonary Bypass Comparative analysis Complications and side effects Computer Simulation Coronary artery bypass Critical Care Medicine Dosage and administration Emergency Medicine Humans Intensive Medicine Medicine & Public Health Original Article Pain Medicine Patient outcomes Physiological aspects Prothrombin Thrombin - metabolism Warfarin Warfarin - adverse effects
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