An in vitro model of the early genetic events in multistage carcinogenesis of malignant insulinoma

The aim of this study was to establish an in vitro model to confirm earlier observations on the role of the myc/ras oncogenes as promoting factors in the process of normal Langerhans islet β cell transformation. For that purpose we infected primary mouse Langerhans islets with a recombinant retrovir...

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Veröffentlicht in:	Carcinogenesis (New York) 1999-08, Vol.20 (8), p.1521-1528
Hauptverfasser:	Katić, Maša, Hadžija, Mirko, Wrischer, Mercedes, Pavelić, Krešimir
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Biological and medical sciences c.f.u Cell Transformation, Neoplastic - genetics colony forming units EGF-R Endocrine pancreas. Apud cells (diseases) Endocrinopathies epidermal growth factor receptor FCS fetal calf serum Genes, myc - physiology Genes, ras - physiology Genetic Vectors - administration & dosage HeBS HEPES-buffered saline pH 7.05 insulinoma Insulinoma - genetics Islets of Langerhans Medical sciences Mice Mice, Inbred CBA myc gene Pancreatic Neoplasms - genetics PBS phosphate-buffered saline ras gene Retroviridae - drug effects TGFα Transfection transforming growth factor α Tumors. Hypoglycemia v-H-ras gene v-myc gene
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