The multidrug resistance P-glycoprotein. Oligomeric state and intramolecular interactions

The human multidrug resistance P-glycoprotein (P-gp), a member of the ATP-binding cassette (ABC) superfamily of transporters, is frequently responsible for the failure of chemotherapy by virtue of its ability to export hydrophobic cytotoxic drugs from cells. Elucidating the inter- and intramolecular...

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Veröffentlicht in:	The Journal of biological chemistry 2001-09, Vol.276 (39), p.36075-36078
Hauptverfasser:	Taylor, J C, Horvath, A R, Higgins, C F, Begley, G S
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP Binding Cassette Transporter, Subfamily B, Member 1 - chemistry ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism Cell Line Detergents - pharmacology DNA - metabolism Dose-Response Relationship, Drug Electrophoresis, Polyacrylamide Gel Epitopes - chemistry Humans Octoxynol - pharmacology Precipitin Tests Protein Binding Protein Biosynthesis Protein Structure, Tertiary TAP1 protein TAP2 protein Two-Hybrid System Techniques
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