Nicotine impact on the structure of adult male guinea pig auditory cortex
A growing body of evidence suggests that chronic cigarette smoking causes detrimental effects on brain morphology. To study the structural changes in auditory cortex region (Layer V), under the influence of nicotine. Three animal groups (10 each) were used; group I (control) and groups IIa and IIb r...
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| Veröffentlicht in: | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2016-02, Vol.68 (2-3), p.167-179 |
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| container_title | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie |
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| creator | Elgayar, Sanaa A.M. Hussein, Ola A. Abdel-Hafez, Amel M.M. Thabet, Huda S.A. |
| description | A growing body of evidence suggests that chronic cigarette smoking causes detrimental effects on brain morphology.
To study the structural changes in auditory cortex region (Layer V), under the influence of nicotine.
Three animal groups (10 each) were used; group I (control) and groups IIa and IIb received 3 and 6mg/kg nicotine respectively. The specimens from the auditory cortex were examined using light and electron microscopy and morphometry.
Neurons and blood capillaries of the auditory cortex (layer V), were influenced by chronic nicotine treatment in a dose dependent manner. The neurons and their processes revealed disorganization and dissociation of microtubules. The neuronal cells nucleoli characteristically revealed large fibrillar centers detected by silver stain and ultrastructure. The blood capillaries revealed collapse, irregular lumen, thickened basal lamina, abnormal forms of nuclei and organization of microtubules. Neuroglia revealed marked reactivity. Morphometrically, there was a significant decrease in the thickness of the auditory cortex and the number of light neurons and a significant increase in the number of dark neurons in comparison to the control.
Nicotine affects the integrity of the auditory cortex possibly by reducing metabolic and transcription activities. |
| doi_str_mv | 10.1016/j.etp.2015.11.009 |
| format | Article |
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To study the structural changes in auditory cortex region (Layer V), under the influence of nicotine.
Three animal groups (10 each) were used; group I (control) and groups IIa and IIb received 3 and 6mg/kg nicotine respectively. The specimens from the auditory cortex were examined using light and electron microscopy and morphometry.
Neurons and blood capillaries of the auditory cortex (layer V), were influenced by chronic nicotine treatment in a dose dependent manner. The neurons and their processes revealed disorganization and dissociation of microtubules. The neuronal cells nucleoli characteristically revealed large fibrillar centers detected by silver stain and ultrastructure. The blood capillaries revealed collapse, irregular lumen, thickened basal lamina, abnormal forms of nuclei and organization of microtubules. Neuroglia revealed marked reactivity. Morphometrically, there was a significant decrease in the thickness of the auditory cortex and the number of light neurons and a significant increase in the number of dark neurons in comparison to the control.
Nicotine affects the integrity of the auditory cortex possibly by reducing metabolic and transcription activities.</description><identifier>ISSN: 0940-2993</identifier><identifier>EISSN: 1618-1433</identifier><identifier>DOI: 10.1016/j.etp.2015.11.009</identifier><identifier>PMID: 26686587</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Animals ; Auditory cortex ; Auditory Cortex - drug effects ; Auditory Cortex - ultrastructure ; Cell Count ; Guinea pig ; Guinea Pigs ; Injections, Subcutaneous ; Male ; Microscopy, Electron, Transmission ; Neurons - drug effects ; Neurons - pathology ; Neurons - ultrastructure ; Nicotine ; Nicotine - administration & dosage ; Nicotine - toxicity ; Ultrastructure</subject><ispartof>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2016-02, Vol.68 (2-3), p.167-179</ispartof><rights>2015 Elsevier GmbH</rights><rights>Copyright © 2015 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-bd4eac35a67084f72f9306e256cd082fa9485b4623cc52b1bc441c0c5f8ed2203</citedby><cites>FETCH-LOGICAL-c526t-bd4eac35a67084f72f9306e256cd082fa9485b4623cc52b1bc441c0c5f8ed2203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.etp.2015.11.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26686587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elgayar, Sanaa A.M.</creatorcontrib><creatorcontrib>Hussein, Ola A.</creatorcontrib><creatorcontrib>Abdel-Hafez, Amel M.M.</creatorcontrib><creatorcontrib>Thabet, Huda S.A.</creatorcontrib><title>Nicotine impact on the structure of adult male guinea pig auditory cortex</title><title>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</title><addtitle>Exp Toxicol Pathol</addtitle><description>A growing body of evidence suggests that chronic cigarette smoking causes detrimental effects on brain morphology.
To study the structural changes in auditory cortex region (Layer V), under the influence of nicotine.
Three animal groups (10 each) were used; group I (control) and groups IIa and IIb received 3 and 6mg/kg nicotine respectively. The specimens from the auditory cortex were examined using light and electron microscopy and morphometry.
Neurons and blood capillaries of the auditory cortex (layer V), were influenced by chronic nicotine treatment in a dose dependent manner. The neurons and their processes revealed disorganization and dissociation of microtubules. The neuronal cells nucleoli characteristically revealed large fibrillar centers detected by silver stain and ultrastructure. The blood capillaries revealed collapse, irregular lumen, thickened basal lamina, abnormal forms of nuclei and organization of microtubules. Neuroglia revealed marked reactivity. Morphometrically, there was a significant decrease in the thickness of the auditory cortex and the number of light neurons and a significant increase in the number of dark neurons in comparison to the control.
Nicotine affects the integrity of the auditory cortex possibly by reducing metabolic and transcription activities.</description><subject>Animals</subject><subject>Auditory cortex</subject><subject>Auditory Cortex - drug effects</subject><subject>Auditory Cortex - ultrastructure</subject><subject>Cell Count</subject><subject>Guinea pig</subject><subject>Guinea Pigs</subject><subject>Injections, Subcutaneous</subject><subject>Male</subject><subject>Microscopy, Electron, Transmission</subject><subject>Neurons - drug effects</subject><subject>Neurons - pathology</subject><subject>Neurons - ultrastructure</subject><subject>Nicotine</subject><subject>Nicotine - administration & dosage</subject><subject>Nicotine - toxicity</subject><subject>Ultrastructure</subject><issn>0940-2993</issn><issn>1618-1433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkL2O1DAURi0EYoeFB6BBLmkS7nVsxxYVWvGz0goaqC3HuVk8SsbBdhD79mQ1CyWi-przneIw9hKhRUD95thSXVsBqFrEFsA-YgfUaBqUXfeYHcBKaIS13QV7VsoRQIBV-JRdCK2NVqY_sOvPMaQaT8TjsvpQeTrx-p14qXkLdcvE08T9uM2VL34mfrvtrOdrvOV-G2NN-Y6HlCv9es6eTH4u9OJhL9m3D--_Xn1qbr58vL56d9MEJXRthlGSD53yugcjp15MtgNNQukwghGTt9KoQWrRhf0w4BCkxABBTYZGIaC7ZK_P3jWnHxuV6pZYAs2zP1HaisPegu2VAf0fqFYWjerkjuIZDTmVkmlya46Lz3cOwd3Hdke3x3b3sR2i22Pvn1cP-m1YaPz7-FN3B96eAdp7_IyUXQmRToHGmClUN6b4D_1vyk6O0A</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Elgayar, Sanaa A.M.</creator><creator>Hussein, Ola A.</creator><creator>Abdel-Hafez, Amel M.M.</creator><creator>Thabet, Huda S.A.</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20160201</creationdate><title>Nicotine impact on the structure of adult male guinea pig auditory cortex</title><author>Elgayar, Sanaa A.M. ; Hussein, Ola A. ; Abdel-Hafez, Amel M.M. ; Thabet, Huda S.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-bd4eac35a67084f72f9306e256cd082fa9485b4623cc52b1bc441c0c5f8ed2203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Auditory cortex</topic><topic>Auditory Cortex - drug effects</topic><topic>Auditory Cortex - ultrastructure</topic><topic>Cell Count</topic><topic>Guinea pig</topic><topic>Guinea Pigs</topic><topic>Injections, Subcutaneous</topic><topic>Male</topic><topic>Microscopy, Electron, Transmission</topic><topic>Neurons - drug effects</topic><topic>Neurons - pathology</topic><topic>Neurons - ultrastructure</topic><topic>Nicotine</topic><topic>Nicotine - administration & dosage</topic><topic>Nicotine - toxicity</topic><topic>Ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elgayar, Sanaa A.M.</creatorcontrib><creatorcontrib>Hussein, Ola A.</creatorcontrib><creatorcontrib>Abdel-Hafez, Amel M.M.</creatorcontrib><creatorcontrib>Thabet, Huda S.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elgayar, Sanaa A.M.</au><au>Hussein, Ola A.</au><au>Abdel-Hafez, Amel M.M.</au><au>Thabet, Huda S.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nicotine impact on the structure of adult male guinea pig auditory cortex</atitle><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle><addtitle>Exp Toxicol Pathol</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>68</volume><issue>2-3</issue><spage>167</spage><epage>179</epage><pages>167-179</pages><issn>0940-2993</issn><eissn>1618-1433</eissn><abstract>A growing body of evidence suggests that chronic cigarette smoking causes detrimental effects on brain morphology.
To study the structural changes in auditory cortex region (Layer V), under the influence of nicotine.
Three animal groups (10 each) were used; group I (control) and groups IIa and IIb received 3 and 6mg/kg nicotine respectively. The specimens from the auditory cortex were examined using light and electron microscopy and morphometry.
Neurons and blood capillaries of the auditory cortex (layer V), were influenced by chronic nicotine treatment in a dose dependent manner. The neurons and their processes revealed disorganization and dissociation of microtubules. The neuronal cells nucleoli characteristically revealed large fibrillar centers detected by silver stain and ultrastructure. The blood capillaries revealed collapse, irregular lumen, thickened basal lamina, abnormal forms of nuclei and organization of microtubules. Neuroglia revealed marked reactivity. Morphometrically, there was a significant decrease in the thickness of the auditory cortex and the number of light neurons and a significant increase in the number of dark neurons in comparison to the control.
Nicotine affects the integrity of the auditory cortex possibly by reducing metabolic and transcription activities.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>26686587</pmid><doi>10.1016/j.etp.2015.11.009</doi><tpages>13</tpages></addata></record> |
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| identifier | ISSN: 0940-2993 |
| ispartof | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2016-02, Vol.68 (2-3), p.167-179 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Auditory cortex Auditory Cortex - drug effects Auditory Cortex - ultrastructure Cell Count Guinea pig Guinea Pigs Injections, Subcutaneous Male Microscopy, Electron, Transmission Neurons - drug effects Neurons - pathology Neurons - ultrastructure Nicotine Nicotine - administration & dosage Nicotine - toxicity Ultrastructure |
| title | Nicotine impact on the structure of adult male guinea pig auditory cortex |
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