Cocaine-induced behavioral sensitization decreases the expression of endocannabinoid signaling-related proteins in the mouse hippocampus

Abstract In the reward mesocorticolimbic circuits, the glutamatergic and endocannabinoid systems are implicated in neurobiological mechanisms underlying cocaine addiction. However, the involvement of both systems in the hippocampus, a critical region to process relational information relevant for en...

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Veröffentlicht in:	European neuropsychopharmacology 2016-03, Vol.26 (3), p.477-492
Hauptverfasser:	Blanco, Eduardo, Galeano, Pablo, Palomino, Ana, Pavón, Francisco J, Rivera, Patricia, Serrano, Antonia, Alen, Francisco, Rubio, Leticia, Vargas, Antonio, Castilla-Ortega, Estela, Decara, Juan, Bilbao, Ainhoa, de Fonseca, Fernando Rodríguez, Suárez, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - genetics Amidohydrolases - metabolism Analysis of Variance Animals Cannabinoid Cocaine Cocaine - pharmacology Cocaine sensitization Conditioned locomotion Dopamine Uptake Inhibitors - pharmacology Endocannabinoids - genetics Endocannabinoids - metabolism Gene Expression Regulation - drug effects Glutamate Glutamic Acid - metabolism Hippocampus Hippocampus - drug effects Hippocampus - metabolism Internal Medicine Locomotion - drug effects Male Mice Mice, Inbred C57BL Psychiatry Receptors, Glutamate - genetics Receptors, Glutamate - metabolism RNA, Messenger - metabolism Signal Transduction - drug effects Signal Transduction - genetics Time Factors
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