New pentasubstituted pyrrole hybrid atorvastatin–quinoline derivatives with antiplasmodial activity

[Display omitted] Cerebral malaria is caused by Plasmodium falciparum. Atorvastatin (AVA) is a pentasubstituted pyrrole, which has been tested as an adjuvant in the treatment of cerebral malaria. Herein, a new class of hybrids of AVA and aminoquinolines (primaquine and chloroquine derivatives) has b...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2016-04, Vol.26 (8), p.1881-1884
Hauptverfasser:	Carvalho, Rita C.C., Martins, Wagner A., Silva, Tayara P., Kaiser, Carlos R., Bastos, Mônica M., Pinheiro, Luiz C.S., Krettli, Antoniana U., Boechat, Núbia
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials - chemical synthesis Antimalarials - chemistry Antimalarials - pharmacology Atorvastatin Atorvastatin Calcium - chemistry Atorvastatin Calcium - pharmacology Chloroquine Dose-Response Relationship, Drug Malaria Molecular Structure Parasitic Sensitivity Tests Pentasubstituted pyrrole Plasmodium falciparum Plasmodium falciparum - drug effects Primaquine Pyrroles - chemistry Pyrroles - pharmacology Quinolines - chemistry Quinolines - pharmacology Structure-Activity Relationship
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