Role of major resection in pulmonary metastasectomy for colorectal cancer in the Spanish prospective multicenter study (GECMP-CCR)
Patients with pulmonary metastases from colorectal cancer (CRC) may benefit from aggressive surgical therapy. The objective of this study was to determine the role of major anatomic resection for pulmonary metastasectomy to improve survival when compared with limited pulmonary resection. Data of 522...
Gespeichert in:
| Veröffentlicht in: | Annals of oncology 2016-05, Vol.27 (5), p.850-855 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 855 |
|---|---|
| container_issue | 5 |
| container_start_page | 850 |
| container_title | Annals of oncology |
| container_volume | 27 |
| creator | Hernández, J. Molins, L. Fibla, J.J. Heras, F. Embún, R. Rivas, J.J. Rivas, JuanJ Molins, Laureano Embún, Raúl Rivas, Francisco Hernández, Jorge Mier, JoséManuel Heras, Félix de la Cruz, Javier Rubio, Matilde Fernández, Esther Carbajo, Miguel Peñalver, Rafael Jarabo, JoséRamón González-Rivas, Diego Bolufer, Sergio Pagás, Carlos Call, Sergi Smith, David Wins, Richard Arnau, Antonio Arroyo, Andrés Marrón, M.Carmen Tamura, Akiko Blanco, Montse de Olaiz, Beatriz Muñoz, Gemma García Prim, José M. Rombolá, Carlos Barajas, Santiago García Rodríguez, Alberto Freixinet, Jorge Ruiz, Javier Carriquiry, Guillermo Rosenberg, Moisés Canalís, Emilio |
| description | Patients with pulmonary metastases from colorectal cancer (CRC) may benefit from aggressive surgical therapy. The objective of this study was to determine the role of major anatomic resection for pulmonary metastasectomy to improve survival when compared with limited pulmonary resection.
Data of 522 patients (64.2% men, mean age 64.5 years) who underwent pulmonary resections with curative intent for CRC metastases over a 2-year period were reviewed. All patients were followed for a minimum of 3 years. Disease-specific survival (DSS) and disease-free survival (DFS) were assessed with the Kaplan–Meier method. Factors associated with DSS and DFS were analyzed using a Cox proportional hazards regression model.
A total of 394 (75.6%) patients underwent wedge resection, 19 (3.6%) anatomic segmentectomy, 5 (0.9%) lesser resections not described, 100 (19.3%) lobectomy, and 4 (0.8%) pneumonectomy. Accordingly, 104 (19.9%) patients were treated with major anatomic resection and 418 (80.1%) with lesser resection. Operations were carried out with video-assisted thoracoscopic surgery (VATS) in 93 patients. The overall DSS and DFS were 55 and 28.3 months, respectively. Significant differences in DSS and DFS in favor of major resection versus lesser resection (DSS median not reached versus 52.2 months, P = 0.03; DFS median not reached versus 23.9 months, P < 0.001) were found. In the multivariate analysis, major resection appeared to be a protective factor in DSS [hazard ratio (HR) 0.6, 95% confidence interval (CI) 0.41–0.96, P = 0.031] and DFS (HR 0.5, 95% CI 0.36–0.75, P < 0.001). The surgical approach (VATS versus open surgical resection) had no effect on outcome.
Major anatomic resection with lymphadenectomy for pulmonary metastasectomy can be considered in selected CRC patient with sufficient functional reserve to improve the DSS and DFS. Further prospective randomized studies are needed to confirm the present results. |
| doi_str_mv | 10.1093/annonc/mdw064 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1790964755</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S092375341937440X</els_id><sourcerecordid>1784747060</sourcerecordid><originalsourceid>FETCH-LOGICAL-c413t-4c0e574553b38623f42540a43b7b591b02487aafd590b9abac68576197e177a3</originalsourceid><addsrcrecordid>eNqFkUFrHSEUhaU0NK9pl90Wl-liGh11HJdlSJNCQkKavTjOHWIYdaozCW_bXx4fk3ZXChfk4ue513MQ-kTJV0oUOzMhxGDP_PBMGv4G7ahoVNUSTt-iHVE1q6Rg_Bi9z_mRENKoWr1Dx7WklNWS7NDvuzgBjiP25jEmnCCDXVwM2AU8r5OPwaQ99rCYXKrcRb_HYyFtnGIqvZmwNcFCOrxYHgD_nE1w-QHPKeb5IPYE2K_T4iyEpWB5WYc9Pr04765vq667-_IBHY1myvDx9TxB99_P77vL6urm4kf37aqynLKl4paAkFwI1rO2qdnIa8GJ4ayXvVC0JzVvpTHjIBTplemNbVohG6okUCkNO0Gnm2xZ7NcKedHeZQvTZALENWsqFVENl2XA_9GWSy5JQwpabagt380JRj0n54tnmhJ9CEhvAektoMJ_fpVeew_DX_pPIgWQGwDFiicHSWfroBg8uIPdeojuH9Ivr2iibw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1784747060</pqid></control><display><type>article</type><title>Role of major resection in pulmonary metastasectomy for colorectal cancer in the Spanish prospective multicenter study (GECMP-CCR)</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Hernández, J. ; Molins, L. ; Fibla, J.J. ; Heras, F. ; Embún, R. ; Rivas, J.J. ; Rivas, JuanJ ; Molins, Laureano ; Embún, Raúl ; Rivas, Francisco ; Hernández, Jorge ; Mier, JoséManuel ; Heras, Félix ; de la Cruz, Javier ; Rubio, Matilde ; Fernández, Esther ; Carbajo, Miguel ; Peñalver, Rafael ; Jarabo, JoséRamón ; González-Rivas, Diego ; Bolufer, Sergio ; Pagás, Carlos ; Call, Sergi ; Smith, David ; Wins, Richard ; Arnau, Antonio ; Arroyo, Andrés ; Marrón, M.Carmen ; Tamura, Akiko ; Blanco, Montse ; de Olaiz, Beatriz ; Muñoz, Gemma ; García Prim, José M. ; Rombolá, Carlos ; Barajas, Santiago García ; Rodríguez, Alberto ; Freixinet, Jorge ; Ruiz, Javier ; Carriquiry, Guillermo ; Rosenberg, Moisés ; Canalís, Emilio</creator><creatorcontrib>Hernández, J. ; Molins, L. ; Fibla, J.J. ; Heras, F. ; Embún, R. ; Rivas, J.J. ; Rivas, JuanJ ; Molins, Laureano ; Embún, Raúl ; Rivas, Francisco ; Hernández, Jorge ; Mier, JoséManuel ; Heras, Félix ; de la Cruz, Javier ; Rubio, Matilde ; Fernández, Esther ; Carbajo, Miguel ; Peñalver, Rafael ; Jarabo, JoséRamón ; González-Rivas, Diego ; Bolufer, Sergio ; Pagás, Carlos ; Call, Sergi ; Smith, David ; Wins, Richard ; Arnau, Antonio ; Arroyo, Andrés ; Marrón, M.Carmen ; Tamura, Akiko ; Blanco, Montse ; de Olaiz, Beatriz ; Muñoz, Gemma ; García Prim, José M. ; Rombolá, Carlos ; Barajas, Santiago García ; Rodríguez, Alberto ; Freixinet, Jorge ; Ruiz, Javier ; Carriquiry, Guillermo ; Rosenberg, Moisés ; Canalís, Emilio ; on behalf of the Grupo Español de Metástasis Pulmonares de Carcinoma Colo-Rectal (GECMP-CCR) de la Sociedad Española de Neumología y Cirugía Torácica (SEPAR) ; Grupo Español de Metástasis Pulmonares de Carcinoma Colo-Rectal (GECMP-CCR) de la Sociedad Española de Neumología y Cirugía Torácica (SEPAR)</creatorcontrib><description>Patients with pulmonary metastases from colorectal cancer (CRC) may benefit from aggressive surgical therapy. The objective of this study was to determine the role of major anatomic resection for pulmonary metastasectomy to improve survival when compared with limited pulmonary resection.
Data of 522 patients (64.2% men, mean age 64.5 years) who underwent pulmonary resections with curative intent for CRC metastases over a 2-year period were reviewed. All patients were followed for a minimum of 3 years. Disease-specific survival (DSS) and disease-free survival (DFS) were assessed with the Kaplan–Meier method. Factors associated with DSS and DFS were analyzed using a Cox proportional hazards regression model.
A total of 394 (75.6%) patients underwent wedge resection, 19 (3.6%) anatomic segmentectomy, 5 (0.9%) lesser resections not described, 100 (19.3%) lobectomy, and 4 (0.8%) pneumonectomy. Accordingly, 104 (19.9%) patients were treated with major anatomic resection and 418 (80.1%) with lesser resection. Operations were carried out with video-assisted thoracoscopic surgery (VATS) in 93 patients. The overall DSS and DFS were 55 and 28.3 months, respectively. Significant differences in DSS and DFS in favor of major resection versus lesser resection (DSS median not reached versus 52.2 months, P = 0.03; DFS median not reached versus 23.9 months, P < 0.001) were found. In the multivariate analysis, major resection appeared to be a protective factor in DSS [hazard ratio (HR) 0.6, 95% confidence interval (CI) 0.41–0.96, P = 0.031] and DFS (HR 0.5, 95% CI 0.36–0.75, P < 0.001). The surgical approach (VATS versus open surgical resection) had no effect on outcome.
Major anatomic resection with lymphadenectomy for pulmonary metastasectomy can be considered in selected CRC patient with sufficient functional reserve to improve the DSS and DFS. Further prospective randomized studies are needed to confirm the present results.</description><identifier>ISSN: 0923-7534</identifier><identifier>EISSN: 1569-8041</identifier><identifier>DOI: 10.1093/annonc/mdw064</identifier><identifier>PMID: 27113270</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aged ; colorectal carcinoma ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Disease-Free Survival ; Female ; Humans ; lobectomy ; lung metastasis ; Lung Neoplasms - pathology ; Lung Neoplasms - secondary ; Lung Neoplasms - surgery ; Lymph Node Excision - methods ; Male ; Metastasectomy ; Middle Aged ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - surgery ; pneumonectomy ; Pneumonectomy - methods ; Proportional Hazards Models ; Spain ; Thoracic Surgery, Video-Assisted - methods ; VATS ; wedge resection</subject><ispartof>Annals of oncology, 2016-05, Vol.27 (5), p.850-855</ispartof><rights>2016 European Society for Medical Oncology</rights><rights>The Author 2016. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-4c0e574553b38623f42540a43b7b591b02487aafd590b9abac68576197e177a3</citedby><cites>FETCH-LOGICAL-c413t-4c0e574553b38623f42540a43b7b591b02487aafd590b9abac68576197e177a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27113270$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hernández, J.</creatorcontrib><creatorcontrib>Molins, L.</creatorcontrib><creatorcontrib>Fibla, J.J.</creatorcontrib><creatorcontrib>Heras, F.</creatorcontrib><creatorcontrib>Embún, R.</creatorcontrib><creatorcontrib>Rivas, J.J.</creatorcontrib><creatorcontrib>Rivas, JuanJ</creatorcontrib><creatorcontrib>Molins, Laureano</creatorcontrib><creatorcontrib>Embún, Raúl</creatorcontrib><creatorcontrib>Rivas, Francisco</creatorcontrib><creatorcontrib>Hernández, Jorge</creatorcontrib><creatorcontrib>Mier, JoséManuel</creatorcontrib><creatorcontrib>Heras, Félix</creatorcontrib><creatorcontrib>de la Cruz, Javier</creatorcontrib><creatorcontrib>Rubio, Matilde</creatorcontrib><creatorcontrib>Fernández, Esther</creatorcontrib><creatorcontrib>Carbajo, Miguel</creatorcontrib><creatorcontrib>Peñalver, Rafael</creatorcontrib><creatorcontrib>Jarabo, JoséRamón</creatorcontrib><creatorcontrib>González-Rivas, Diego</creatorcontrib><creatorcontrib>Bolufer, Sergio</creatorcontrib><creatorcontrib>Pagás, Carlos</creatorcontrib><creatorcontrib>Call, Sergi</creatorcontrib><creatorcontrib>Smith, David</creatorcontrib><creatorcontrib>Wins, Richard</creatorcontrib><creatorcontrib>Arnau, Antonio</creatorcontrib><creatorcontrib>Arroyo, Andrés</creatorcontrib><creatorcontrib>Marrón, M.Carmen</creatorcontrib><creatorcontrib>Tamura, Akiko</creatorcontrib><creatorcontrib>Blanco, Montse</creatorcontrib><creatorcontrib>de Olaiz, Beatriz</creatorcontrib><creatorcontrib>Muñoz, Gemma</creatorcontrib><creatorcontrib>García Prim, José M.</creatorcontrib><creatorcontrib>Rombolá, Carlos</creatorcontrib><creatorcontrib>Barajas, Santiago García</creatorcontrib><creatorcontrib>Rodríguez, Alberto</creatorcontrib><creatorcontrib>Freixinet, Jorge</creatorcontrib><creatorcontrib>Ruiz, Javier</creatorcontrib><creatorcontrib>Carriquiry, Guillermo</creatorcontrib><creatorcontrib>Rosenberg, Moisés</creatorcontrib><creatorcontrib>Canalís, Emilio</creatorcontrib><creatorcontrib>on behalf of the Grupo Español de Metástasis Pulmonares de Carcinoma Colo-Rectal (GECMP-CCR) de la Sociedad Española de Neumología y Cirugía Torácica (SEPAR)</creatorcontrib><creatorcontrib>Grupo Español de Metástasis Pulmonares de Carcinoma Colo-Rectal (GECMP-CCR) de la Sociedad Española de Neumología y Cirugía Torácica (SEPAR)</creatorcontrib><title>Role of major resection in pulmonary metastasectomy for colorectal cancer in the Spanish prospective multicenter study (GECMP-CCR)</title><title>Annals of oncology</title><addtitle>Ann Oncol</addtitle><description>Patients with pulmonary metastases from colorectal cancer (CRC) may benefit from aggressive surgical therapy. The objective of this study was to determine the role of major anatomic resection for pulmonary metastasectomy to improve survival when compared with limited pulmonary resection.
Data of 522 patients (64.2% men, mean age 64.5 years) who underwent pulmonary resections with curative intent for CRC metastases over a 2-year period were reviewed. All patients were followed for a minimum of 3 years. Disease-specific survival (DSS) and disease-free survival (DFS) were assessed with the Kaplan–Meier method. Factors associated with DSS and DFS were analyzed using a Cox proportional hazards regression model.
A total of 394 (75.6%) patients underwent wedge resection, 19 (3.6%) anatomic segmentectomy, 5 (0.9%) lesser resections not described, 100 (19.3%) lobectomy, and 4 (0.8%) pneumonectomy. Accordingly, 104 (19.9%) patients were treated with major anatomic resection and 418 (80.1%) with lesser resection. Operations were carried out with video-assisted thoracoscopic surgery (VATS) in 93 patients. The overall DSS and DFS were 55 and 28.3 months, respectively. Significant differences in DSS and DFS in favor of major resection versus lesser resection (DSS median not reached versus 52.2 months, P = 0.03; DFS median not reached versus 23.9 months, P < 0.001) were found. In the multivariate analysis, major resection appeared to be a protective factor in DSS [hazard ratio (HR) 0.6, 95% confidence interval (CI) 0.41–0.96, P = 0.031] and DFS (HR 0.5, 95% CI 0.36–0.75, P < 0.001). The surgical approach (VATS versus open surgical resection) had no effect on outcome.
Major anatomic resection with lymphadenectomy for pulmonary metastasectomy can be considered in selected CRC patient with sufficient functional reserve to improve the DSS and DFS. Further prospective randomized studies are needed to confirm the present results.</description><subject>Aged</subject><subject>colorectal carcinoma</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>lobectomy</subject><subject>lung metastasis</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - secondary</subject><subject>Lung Neoplasms - surgery</subject><subject>Lymph Node Excision - methods</subject><subject>Male</subject><subject>Metastasectomy</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>pneumonectomy</subject><subject>Pneumonectomy - methods</subject><subject>Proportional Hazards Models</subject><subject>Spain</subject><subject>Thoracic Surgery, Video-Assisted - methods</subject><subject>VATS</subject><subject>wedge resection</subject><issn>0923-7534</issn><issn>1569-8041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFrHSEUhaU0NK9pl90Wl-liGh11HJdlSJNCQkKavTjOHWIYdaozCW_bXx4fk3ZXChfk4ue513MQ-kTJV0oUOzMhxGDP_PBMGv4G7ahoVNUSTt-iHVE1q6Rg_Bi9z_mRENKoWr1Dx7WklNWS7NDvuzgBjiP25jEmnCCDXVwM2AU8r5OPwaQ99rCYXKrcRb_HYyFtnGIqvZmwNcFCOrxYHgD_nE1w-QHPKeb5IPYE2K_T4iyEpWB5WYc9Pr04765vq667-_IBHY1myvDx9TxB99_P77vL6urm4kf37aqynLKl4paAkFwI1rO2qdnIa8GJ4ayXvVC0JzVvpTHjIBTplemNbVohG6okUCkNO0Gnm2xZ7NcKedHeZQvTZALENWsqFVENl2XA_9GWSy5JQwpabagt380JRj0n54tnmhJ9CEhvAektoMJ_fpVeew_DX_pPIgWQGwDFiicHSWfroBg8uIPdeojuH9Ivr2iibw</recordid><startdate>201605</startdate><enddate>201605</enddate><creator>Hernández, J.</creator><creator>Molins, L.</creator><creator>Fibla, J.J.</creator><creator>Heras, F.</creator><creator>Embún, R.</creator><creator>Rivas, J.J.</creator><creator>Rivas, JuanJ</creator><creator>Molins, Laureano</creator><creator>Embún, Raúl</creator><creator>Rivas, Francisco</creator><creator>Hernández, Jorge</creator><creator>Mier, JoséManuel</creator><creator>Heras, Félix</creator><creator>de la Cruz, Javier</creator><creator>Rubio, Matilde</creator><creator>Fernández, Esther</creator><creator>Carbajo, Miguel</creator><creator>Peñalver, Rafael</creator><creator>Jarabo, JoséRamón</creator><creator>González-Rivas, Diego</creator><creator>Bolufer, Sergio</creator><creator>Pagás, Carlos</creator><creator>Call, Sergi</creator><creator>Smith, David</creator><creator>Wins, Richard</creator><creator>Arnau, Antonio</creator><creator>Arroyo, Andrés</creator><creator>Marrón, M.Carmen</creator><creator>Tamura, Akiko</creator><creator>Blanco, Montse</creator><creator>de Olaiz, Beatriz</creator><creator>Muñoz, Gemma</creator><creator>García Prim, José M.</creator><creator>Rombolá, Carlos</creator><creator>Barajas, Santiago García</creator><creator>Rodríguez, Alberto</creator><creator>Freixinet, Jorge</creator><creator>Ruiz, Javier</creator><creator>Carriquiry, Guillermo</creator><creator>Rosenberg, Moisés</creator><creator>Canalís, Emilio</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TO</scope><scope>H94</scope></search><sort><creationdate>201605</creationdate><title>Role of major resection in pulmonary metastasectomy for colorectal cancer in the Spanish prospective multicenter study (GECMP-CCR)</title><author>Hernández, J. ; Molins, L. ; Fibla, J.J. ; Heras, F. ; Embún, R. ; Rivas, J.J. ; Rivas, JuanJ ; Molins, Laureano ; Embún, Raúl ; Rivas, Francisco ; Hernández, Jorge ; Mier, JoséManuel ; Heras, Félix ; de la Cruz, Javier ; Rubio, Matilde ; Fernández, Esther ; Carbajo, Miguel ; Peñalver, Rafael ; Jarabo, JoséRamón ; González-Rivas, Diego ; Bolufer, Sergio ; Pagás, Carlos ; Call, Sergi ; Smith, David ; Wins, Richard ; Arnau, Antonio ; Arroyo, Andrés ; Marrón, M.Carmen ; Tamura, Akiko ; Blanco, Montse ; de Olaiz, Beatriz ; Muñoz, Gemma ; García Prim, José M. ; Rombolá, Carlos ; Barajas, Santiago García ; Rodríguez, Alberto ; Freixinet, Jorge ; Ruiz, Javier ; Carriquiry, Guillermo ; Rosenberg, Moisés ; Canalís, Emilio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-4c0e574553b38623f42540a43b7b591b02487aafd590b9abac68576197e177a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>colorectal carcinoma</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>lobectomy</topic><topic>lung metastasis</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - secondary</topic><topic>Lung Neoplasms - surgery</topic><topic>Lymph Node Excision - methods</topic><topic>Male</topic><topic>Metastasectomy</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>pneumonectomy</topic><topic>Pneumonectomy - methods</topic><topic>Proportional Hazards Models</topic><topic>Spain</topic><topic>Thoracic Surgery, Video-Assisted - methods</topic><topic>VATS</topic><topic>wedge resection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hernández, J.</creatorcontrib><creatorcontrib>Molins, L.</creatorcontrib><creatorcontrib>Fibla, J.J.</creatorcontrib><creatorcontrib>Heras, F.</creatorcontrib><creatorcontrib>Embún, R.</creatorcontrib><creatorcontrib>Rivas, J.J.</creatorcontrib><creatorcontrib>Rivas, JuanJ</creatorcontrib><creatorcontrib>Molins, Laureano</creatorcontrib><creatorcontrib>Embún, Raúl</creatorcontrib><creatorcontrib>Rivas, Francisco</creatorcontrib><creatorcontrib>Hernández, Jorge</creatorcontrib><creatorcontrib>Mier, JoséManuel</creatorcontrib><creatorcontrib>Heras, Félix</creatorcontrib><creatorcontrib>de la Cruz, Javier</creatorcontrib><creatorcontrib>Rubio, Matilde</creatorcontrib><creatorcontrib>Fernández, Esther</creatorcontrib><creatorcontrib>Carbajo, Miguel</creatorcontrib><creatorcontrib>Peñalver, Rafael</creatorcontrib><creatorcontrib>Jarabo, JoséRamón</creatorcontrib><creatorcontrib>González-Rivas, Diego</creatorcontrib><creatorcontrib>Bolufer, Sergio</creatorcontrib><creatorcontrib>Pagás, Carlos</creatorcontrib><creatorcontrib>Call, Sergi</creatorcontrib><creatorcontrib>Smith, David</creatorcontrib><creatorcontrib>Wins, Richard</creatorcontrib><creatorcontrib>Arnau, Antonio</creatorcontrib><creatorcontrib>Arroyo, Andrés</creatorcontrib><creatorcontrib>Marrón, M.Carmen</creatorcontrib><creatorcontrib>Tamura, Akiko</creatorcontrib><creatorcontrib>Blanco, Montse</creatorcontrib><creatorcontrib>de Olaiz, Beatriz</creatorcontrib><creatorcontrib>Muñoz, Gemma</creatorcontrib><creatorcontrib>García Prim, José M.</creatorcontrib><creatorcontrib>Rombolá, Carlos</creatorcontrib><creatorcontrib>Barajas, Santiago García</creatorcontrib><creatorcontrib>Rodríguez, Alberto</creatorcontrib><creatorcontrib>Freixinet, Jorge</creatorcontrib><creatorcontrib>Ruiz, Javier</creatorcontrib><creatorcontrib>Carriquiry, Guillermo</creatorcontrib><creatorcontrib>Rosenberg, Moisés</creatorcontrib><creatorcontrib>Canalís, Emilio</creatorcontrib><creatorcontrib>on behalf of the Grupo Español de Metástasis Pulmonares de Carcinoma Colo-Rectal (GECMP-CCR) de la Sociedad Española de Neumología y Cirugía Torácica (SEPAR)</creatorcontrib><creatorcontrib>Grupo Español de Metástasis Pulmonares de Carcinoma Colo-Rectal (GECMP-CCR) de la Sociedad Española de Neumología y Cirugía Torácica (SEPAR)</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Annals of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hernández, J.</au><au>Molins, L.</au><au>Fibla, J.J.</au><au>Heras, F.</au><au>Embún, R.</au><au>Rivas, J.J.</au><au>Rivas, JuanJ</au><au>Molins, Laureano</au><au>Embún, Raúl</au><au>Rivas, Francisco</au><au>Hernández, Jorge</au><au>Mier, JoséManuel</au><au>Heras, Félix</au><au>de la Cruz, Javier</au><au>Rubio, Matilde</au><au>Fernández, Esther</au><au>Carbajo, Miguel</au><au>Peñalver, Rafael</au><au>Jarabo, JoséRamón</au><au>González-Rivas, Diego</au><au>Bolufer, Sergio</au><au>Pagás, Carlos</au><au>Call, Sergi</au><au>Smith, David</au><au>Wins, Richard</au><au>Arnau, Antonio</au><au>Arroyo, Andrés</au><au>Marrón, M.Carmen</au><au>Tamura, Akiko</au><au>Blanco, Montse</au><au>de Olaiz, Beatriz</au><au>Muñoz, Gemma</au><au>García Prim, José M.</au><au>Rombolá, Carlos</au><au>Barajas, Santiago García</au><au>Rodríguez, Alberto</au><au>Freixinet, Jorge</au><au>Ruiz, Javier</au><au>Carriquiry, Guillermo</au><au>Rosenberg, Moisés</au><au>Canalís, Emilio</au><aucorp>on behalf of the Grupo Español de Metástasis Pulmonares de Carcinoma Colo-Rectal (GECMP-CCR) de la Sociedad Española de Neumología y Cirugía Torácica (SEPAR)</aucorp><aucorp>Grupo Español de Metástasis Pulmonares de Carcinoma Colo-Rectal (GECMP-CCR) de la Sociedad Española de Neumología y Cirugía Torácica (SEPAR)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of major resection in pulmonary metastasectomy for colorectal cancer in the Spanish prospective multicenter study (GECMP-CCR)</atitle><jtitle>Annals of oncology</jtitle><addtitle>Ann Oncol</addtitle><date>2016-05</date><risdate>2016</risdate><volume>27</volume><issue>5</issue><spage>850</spage><epage>855</epage><pages>850-855</pages><issn>0923-7534</issn><eissn>1569-8041</eissn><abstract>Patients with pulmonary metastases from colorectal cancer (CRC) may benefit from aggressive surgical therapy. The objective of this study was to determine the role of major anatomic resection for pulmonary metastasectomy to improve survival when compared with limited pulmonary resection.
Data of 522 patients (64.2% men, mean age 64.5 years) who underwent pulmonary resections with curative intent for CRC metastases over a 2-year period were reviewed. All patients were followed for a minimum of 3 years. Disease-specific survival (DSS) and disease-free survival (DFS) were assessed with the Kaplan–Meier method. Factors associated with DSS and DFS were analyzed using a Cox proportional hazards regression model.
A total of 394 (75.6%) patients underwent wedge resection, 19 (3.6%) anatomic segmentectomy, 5 (0.9%) lesser resections not described, 100 (19.3%) lobectomy, and 4 (0.8%) pneumonectomy. Accordingly, 104 (19.9%) patients were treated with major anatomic resection and 418 (80.1%) with lesser resection. Operations were carried out with video-assisted thoracoscopic surgery (VATS) in 93 patients. The overall DSS and DFS were 55 and 28.3 months, respectively. Significant differences in DSS and DFS in favor of major resection versus lesser resection (DSS median not reached versus 52.2 months, P = 0.03; DFS median not reached versus 23.9 months, P < 0.001) were found. In the multivariate analysis, major resection appeared to be a protective factor in DSS [hazard ratio (HR) 0.6, 95% confidence interval (CI) 0.41–0.96, P = 0.031] and DFS (HR 0.5, 95% CI 0.36–0.75, P < 0.001). The surgical approach (VATS versus open surgical resection) had no effect on outcome.
Major anatomic resection with lymphadenectomy for pulmonary metastasectomy can be considered in selected CRC patient with sufficient functional reserve to improve the DSS and DFS. Further prospective randomized studies are needed to confirm the present results.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27113270</pmid><doi>10.1093/annonc/mdw064</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0923-7534 |
| ispartof | Annals of oncology, 2016-05, Vol.27 (5), p.850-855 |
| issn | 0923-7534 1569-8041 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1790964755 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged colorectal carcinoma Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Disease-Free Survival Female Humans lobectomy lung metastasis Lung Neoplasms - pathology Lung Neoplasms - secondary Lung Neoplasms - surgery Lymph Node Excision - methods Male Metastasectomy Middle Aged Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery pneumonectomy Pneumonectomy - methods Proportional Hazards Models Spain Thoracic Surgery, Video-Assisted - methods VATS wedge resection |
| title | Role of major resection in pulmonary metastasectomy for colorectal cancer in the Spanish prospective multicenter study (GECMP-CCR) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T16%3A06%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20major%20resection%20in%20pulmonary%20metastasectomy%20for%20colorectal%20cancer%20in%20the%20Spanish%20prospective%20multicenter%20study%20(GECMP-CCR)&rft.jtitle=Annals%20of%20oncology&rft.au=Hern%C3%A1ndez,%20J.&rft.aucorp=on%20behalf%20of%20the%20Grupo%20Espa%C3%B1ol%20de%20Met%C3%A1stasis%20Pulmonares%20de%20Carcinoma%20Colo-Rectal%20(GECMP-CCR)%20de%20la%20Sociedad%20Espa%C3%B1ola%20de%20Neumolog%C3%ADa%20y%20Cirug%C3%ADa%20Tor%C3%A1cica%20(SEPAR)&rft.date=2016-05&rft.volume=27&rft.issue=5&rft.spage=850&rft.epage=855&rft.pages=850-855&rft.issn=0923-7534&rft.eissn=1569-8041&rft_id=info:doi/10.1093/annonc/mdw064&rft_dat=%3Cproquest_cross%3E1784747060%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1784747060&rft_id=info:pmid/27113270&rft_els_id=S092375341937440X&rfr_iscdi=true |