Multiprobe molecular imaging of an NMDA receptor hypofunction rat model for glutamatergic dysfunction

Abstract There are many indications of a connection between abnormal glutamate transmission through N-methyl- d -aspartate (NMDA) receptor hypofunction and the occurrence of schizophrenia. The importance of metabotropic glutamate receptor subtype 5 (mGluR5) became generally recognized due to its phy...

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Veröffentlicht in:	Psychiatry research. Neuroimaging 2016-02, Vol.248, p.1-11
Hauptverfasser:	Kosten, Lauren, Verhaeghe, Jeroen, Verkerk, Robert, Thomae, David, De Picker, Livia, wyffels, Leonie, Van Eetveldt, Annemie, Dedeurwaerdere, Stefanie, Stroobants, Sigrid, Staelens, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal model Animals Brain - drug effects Brain - metabolism Disease Models, Animal Dizocilpine Maleate - administration & dosage Dizocilpine Maleate - pharmacology Excitatory Amino Acid Antagonists - administration & dosage Excitatory Amino Acid Antagonists - pharmacology Glutamate Glutamic Acid - metabolism Kynurenine - metabolism Male Molecular Imaging Positron-Emission Tomography - methods Psychiatry Radiology Rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Schizophrenia Schizophrenia - metabolism TRYCAT Tryptophan - metabolism
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