Predictive Value of Conventional Ultrasound and Contrast-Enhanced Ultrasound in Early Recurrence of Hepatocellular Carcinoma after Surgical Resection
Abstract The goals of the work described here were to study the pre-operative risk factors associated with early recurrence (ER) of hepatocellular carcinoma (HCC) after surgical resection and discuss the value of conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) in predicting ER o...
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| description | Abstract The goals of the work described here were to study the pre-operative risk factors associated with early recurrence (ER) of hepatocellular carcinoma (HCC) after surgical resection and discuss the value of conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) in predicting ER of HCC, so as to provide more information for optimizing clinical treatment and improving prognosis. A retrospective analysis was conducted on 59 patients who underwent both US and CEUS examinations pre-operatively and surgical resection for HCC between December 2010 and January 2014 in our hospital. The patients' clinical data, laboratory examination data and ultrasonic imaging diagnostic data were collected. Univariate analysis and logistic regression analysis were performed to determine the independent risk factors for ER of HCC after surgical resection. Diagnostic values of independent risk factors in predicting ER were further evaluated. The 59 patients were divided into the ER group (27 cases) and ER-free group (32 cases). There were no significant differences in age and sex between the two groups ( p > 0.05). Univariate analysis revealed that differences in pre-operative serum α-fetoprotein level ≥400 ng/mL ( p = 0.008), tumor diameter ≥5 cm ( p = 0.012), macroscopic vascular invasion ( p = 0.040), “fast wash-out” enhancement pattern ( p = 0.006) and inhomogeneous distribution of contrast agent ( p = 0.031) statistically significantly differed between the two groups. Logistic regression analysis indicated that pre-operative serum AFP level ≥400 ng/mL ( p = 0.024), tumor diameter ≥5 cm ( p = 0.042) and “fast wash-out” enhancement pattern ( p = 0.009) were independent risk factors for ER of HCC; macrovascular invasion ( p = 0.095) and inhomogeneous distribution of contrast agent ( p = 0.628) did not statistically significantly differ between two groups ( p = 0.628). Predictive values of the independent risk factors were further evaluated. The sensitivity of a “fast wash-out” enhancement pattern in predicting ER of HCC post-operatively did not statistically differ from that of tumor diameter ≥5 cm ( p > 0.05), whereas it was significantly higher than the sensitivities of the other predictive indexes ( p |
| doi_str_mv | 10.1016/j.ultrasmedbio.2015.12.010 |
| format | Article |
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A retrospective analysis was conducted on 59 patients who underwent both US and CEUS examinations pre-operatively and surgical resection for HCC between December 2010 and January 2014 in our hospital. The patients' clinical data, laboratory examination data and ultrasonic imaging diagnostic data were collected. Univariate analysis and logistic regression analysis were performed to determine the independent risk factors for ER of HCC after surgical resection. Diagnostic values of independent risk factors in predicting ER were further evaluated. The 59 patients were divided into the ER group (27 cases) and ER-free group (32 cases). There were no significant differences in age and sex between the two groups ( p > 0.05). Univariate analysis revealed that differences in pre-operative serum α-fetoprotein level ≥400 ng/mL ( p = 0.008), tumor diameter ≥5 cm ( p = 0.012), macroscopic vascular invasion ( p = 0.040), “fast wash-out” enhancement pattern ( p = 0.006) and inhomogeneous distribution of contrast agent ( p = 0.031) statistically significantly differed between the two groups. Logistic regression analysis indicated that pre-operative serum AFP level ≥400 ng/mL ( p = 0.024), tumor diameter ≥5 cm ( p = 0.042) and “fast wash-out” enhancement pattern ( p = 0.009) were independent risk factors for ER of HCC; macrovascular invasion ( p = 0.095) and inhomogeneous distribution of contrast agent ( p = 0.628) did not statistically significantly differ between two groups ( p = 0.628). Predictive values of the independent risk factors were further evaluated. The sensitivity of a “fast wash-out” enhancement pattern in predicting ER of HCC post-operatively did not statistically differ from that of tumor diameter ≥5 cm ( p > 0.05), whereas it was significantly higher than the sensitivities of the other predictive indexes ( p < 0.05). A pre-operative serum α-fetoprotein level ≥400 ng/mL, tumor diameter ≥5 cm and “fast wash-out” enhancement pattern are independent risk factors for ER of HCC after surgical resection. In addition, the “fast wash-out” enhancement pattern could probably be used to screen populations at high risk of recurrence owing to its high sensitivity in predicting ER of HCC post-operatively. All these findings provide beneficial information for management of HCC.</description><identifier>ISSN: 0301-5629</identifier><identifier>EISSN: 1879-291X</identifier><identifier>DOI: 10.1016/j.ultrasmedbio.2015.12.010</identifier><identifier>PMID: 26803390</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Age Distribution ; Carcinoma, Hepatocellular - diagnostic imaging ; Carcinoma, Hepatocellular - epidemiology ; Carcinoma, Hepatocellular - surgery ; China - epidemiology ; Contrast Media ; Contrast-enhanced ultrasound ; Early Detection of Cancer - methods ; Female ; Hepatocellular carcinoma ; Humans ; Image Enhancement - methods ; Incidence ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - epidemiology ; Liver Neoplasms - surgery ; Male ; Middle Aged ; Neoplasm Recurrence, Local - diagnostic imaging ; Neoplasm Recurrence, Local - epidemiology ; Neoplasm Recurrence, Local - prevention & control ; Phospholipids ; Prognosis ; Radiology ; Recurrence ; Reproducibility of Results ; Retrospective Studies ; Risk Assessment - methods ; Risk factor ; Sensitivity and Specificity ; Sex Distribution ; Sulfur Hexafluoride ; Treatment Outcome ; Tumor Burden ; Ultrasonography - methods ; Ultrasonography - statistics & numerical data ; Ultrasound</subject><ispartof>Ultrasound in medicine & biology, 2016-05, Vol.42 (5), p.1042-1048</ispartof><rights>World Federation for Ultrasound in Medicine & Biology</rights><rights>2016 World Federation for Ultrasound in Medicine & Biology</rights><rights>Copyright © 2016 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-7857751f73fc48ebbab4a36a3fcce4acdefc34b1d7508f9a912ad8c26885a1d93</citedby><cites>FETCH-LOGICAL-c534t-7857751f73fc48ebbab4a36a3fcce4acdefc34b1d7508f9a912ad8c26885a1d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ultrasmedbio.2015.12.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26803390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yibin</creatorcontrib><creatorcontrib>Liao, Jintang</creatorcontrib><creatorcontrib>Qi, Wenjun</creatorcontrib><creatorcontrib>Xie, Lulu</creatorcontrib><creatorcontrib>Li, Yueyi</creatorcontrib><title>Predictive Value of Conventional Ultrasound and Contrast-Enhanced Ultrasound in Early Recurrence of Hepatocellular Carcinoma after Surgical Resection</title><title>Ultrasound in medicine & biology</title><addtitle>Ultrasound Med Biol</addtitle><description>Abstract The goals of the work described here were to study the pre-operative risk factors associated with early recurrence (ER) of hepatocellular carcinoma (HCC) after surgical resection and discuss the value of conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) in predicting ER of HCC, so as to provide more information for optimizing clinical treatment and improving prognosis. A retrospective analysis was conducted on 59 patients who underwent both US and CEUS examinations pre-operatively and surgical resection for HCC between December 2010 and January 2014 in our hospital. The patients' clinical data, laboratory examination data and ultrasonic imaging diagnostic data were collected. Univariate analysis and logistic regression analysis were performed to determine the independent risk factors for ER of HCC after surgical resection. Diagnostic values of independent risk factors in predicting ER were further evaluated. The 59 patients were divided into the ER group (27 cases) and ER-free group (32 cases). There were no significant differences in age and sex between the two groups ( p > 0.05). Univariate analysis revealed that differences in pre-operative serum α-fetoprotein level ≥400 ng/mL ( p = 0.008), tumor diameter ≥5 cm ( p = 0.012), macroscopic vascular invasion ( p = 0.040), “fast wash-out” enhancement pattern ( p = 0.006) and inhomogeneous distribution of contrast agent ( p = 0.031) statistically significantly differed between the two groups. Logistic regression analysis indicated that pre-operative serum AFP level ≥400 ng/mL ( p = 0.024), tumor diameter ≥5 cm ( p = 0.042) and “fast wash-out” enhancement pattern ( p = 0.009) were independent risk factors for ER of HCC; macrovascular invasion ( p = 0.095) and inhomogeneous distribution of contrast agent ( p = 0.628) did not statistically significantly differ between two groups ( p = 0.628). Predictive values of the independent risk factors were further evaluated. The sensitivity of a “fast wash-out” enhancement pattern in predicting ER of HCC post-operatively did not statistically differ from that of tumor diameter ≥5 cm ( p > 0.05), whereas it was significantly higher than the sensitivities of the other predictive indexes ( p < 0.05). A pre-operative serum α-fetoprotein level ≥400 ng/mL, tumor diameter ≥5 cm and “fast wash-out” enhancement pattern are independent risk factors for ER of HCC after surgical resection. In addition, the “fast wash-out” enhancement pattern could probably be used to screen populations at high risk of recurrence owing to its high sensitivity in predicting ER of HCC post-operatively. All these findings provide beneficial information for management of HCC.</description><subject>Age Distribution</subject><subject>Carcinoma, Hepatocellular - diagnostic imaging</subject><subject>Carcinoma, Hepatocellular - epidemiology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>China - epidemiology</subject><subject>Contrast Media</subject><subject>Contrast-enhanced ultrasound</subject><subject>Early Detection of Cancer - methods</subject><subject>Female</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Incidence</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - epidemiology</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - diagnostic imaging</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Neoplasm Recurrence, Local - prevention & control</subject><subject>Phospholipids</subject><subject>Prognosis</subject><subject>Radiology</subject><subject>Recurrence</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Risk Assessment - methods</subject><subject>Risk factor</subject><subject>Sensitivity and Specificity</subject><subject>Sex Distribution</subject><subject>Sulfur Hexafluoride</subject><subject>Treatment Outcome</subject><subject>Tumor Burden</subject><subject>Ultrasonography - methods</subject><subject>Ultrasonography - statistics & numerical data</subject><subject>Ultrasound</subject><issn>0301-5629</issn><issn>1879-291X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksFu1DAQhi0EokvhFZDFiUu2dpzECQcktCwUqRKopYibNbEn4CVrb-1kpX0Q3he7W1DFqQfLsuaf-T3zDSGvOFtyxpuzzXIepwBxi6a3flkyXi95uWScPSIL3squKDv-_TFZMMF4UTdld0KexbhhjMlGyKfkpGxaJkTHFuT3l4DG6snukX6DcUbqB7rybo9ust7BSK9vvfzsDIV0Uiy_p2LtfoLTaO4LrKNrCOOBXqKeQ8AUz_XOcQeT1ziO8wiBriBo6_wWKAwTBno1hx9WJ6tLjKiz7XPyZIAx4ou7-5Rcf1h_XZ0XF58_flq9uyh0LaqpkG0tZc0HKQZdtdj30FcgGkhPjRVog4MWVc-NrFk7dNDxEkyrU_dtDdx04pS8PtbdBX8zY5zU1sb8T3Do56i47FjXVE3FHyCVksm6kTJJ3xylOvgYAw5qF-wWwkFxpjJBtVH3CapMUPFSJYIp-eWdz9yn8L_Uv8iS4P1RgGkwe4tBRW3zpI0NaXrKePswn7f_ldGjdRnDLzxg3Pg5JPqpLxVTgrrKu5RXiddpi0TViD_Yusyb</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Wang, Yibin</creator><creator>Liao, Jintang</creator><creator>Qi, Wenjun</creator><creator>Xie, Lulu</creator><creator>Li, Yueyi</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20160501</creationdate><title>Predictive Value of Conventional Ultrasound and Contrast-Enhanced Ultrasound in Early Recurrence of Hepatocellular Carcinoma after Surgical Resection</title><author>Wang, Yibin ; Liao, Jintang ; Qi, Wenjun ; Xie, Lulu ; Li, Yueyi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-7857751f73fc48ebbab4a36a3fcce4acdefc34b1d7508f9a912ad8c26885a1d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Age Distribution</topic><topic>Carcinoma, Hepatocellular - diagnostic imaging</topic><topic>Carcinoma, Hepatocellular - epidemiology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>China - epidemiology</topic><topic>Contrast Media</topic><topic>Contrast-enhanced ultrasound</topic><topic>Early Detection of Cancer - methods</topic><topic>Female</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Incidence</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - epidemiology</topic><topic>Liver Neoplasms - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - diagnostic imaging</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Neoplasm Recurrence, Local - prevention & control</topic><topic>Phospholipids</topic><topic>Prognosis</topic><topic>Radiology</topic><topic>Recurrence</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Risk Assessment - methods</topic><topic>Risk factor</topic><topic>Sensitivity and Specificity</topic><topic>Sex Distribution</topic><topic>Sulfur Hexafluoride</topic><topic>Treatment Outcome</topic><topic>Tumor Burden</topic><topic>Ultrasonography - methods</topic><topic>Ultrasonography - statistics & numerical data</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yibin</creatorcontrib><creatorcontrib>Liao, Jintang</creatorcontrib><creatorcontrib>Qi, Wenjun</creatorcontrib><creatorcontrib>Xie, Lulu</creatorcontrib><creatorcontrib>Li, Yueyi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Ultrasound in medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yibin</au><au>Liao, Jintang</au><au>Qi, Wenjun</au><au>Xie, Lulu</au><au>Li, Yueyi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive Value of Conventional Ultrasound and Contrast-Enhanced Ultrasound in Early Recurrence of Hepatocellular Carcinoma after Surgical Resection</atitle><jtitle>Ultrasound in medicine & biology</jtitle><addtitle>Ultrasound Med Biol</addtitle><date>2016-05-01</date><risdate>2016</risdate><volume>42</volume><issue>5</issue><spage>1042</spage><epage>1048</epage><pages>1042-1048</pages><issn>0301-5629</issn><eissn>1879-291X</eissn><abstract>Abstract The goals of the work described here were to study the pre-operative risk factors associated with early recurrence (ER) of hepatocellular carcinoma (HCC) after surgical resection and discuss the value of conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) in predicting ER of HCC, so as to provide more information for optimizing clinical treatment and improving prognosis. A retrospective analysis was conducted on 59 patients who underwent both US and CEUS examinations pre-operatively and surgical resection for HCC between December 2010 and January 2014 in our hospital. The patients' clinical data, laboratory examination data and ultrasonic imaging diagnostic data were collected. Univariate analysis and logistic regression analysis were performed to determine the independent risk factors for ER of HCC after surgical resection. Diagnostic values of independent risk factors in predicting ER were further evaluated. The 59 patients were divided into the ER group (27 cases) and ER-free group (32 cases). There were no significant differences in age and sex between the two groups ( p > 0.05). Univariate analysis revealed that differences in pre-operative serum α-fetoprotein level ≥400 ng/mL ( p = 0.008), tumor diameter ≥5 cm ( p = 0.012), macroscopic vascular invasion ( p = 0.040), “fast wash-out” enhancement pattern ( p = 0.006) and inhomogeneous distribution of contrast agent ( p = 0.031) statistically significantly differed between the two groups. Logistic regression analysis indicated that pre-operative serum AFP level ≥400 ng/mL ( p = 0.024), tumor diameter ≥5 cm ( p = 0.042) and “fast wash-out” enhancement pattern ( p = 0.009) were independent risk factors for ER of HCC; macrovascular invasion ( p = 0.095) and inhomogeneous distribution of contrast agent ( p = 0.628) did not statistically significantly differ between two groups ( p = 0.628). Predictive values of the independent risk factors were further evaluated. The sensitivity of a “fast wash-out” enhancement pattern in predicting ER of HCC post-operatively did not statistically differ from that of tumor diameter ≥5 cm ( p > 0.05), whereas it was significantly higher than the sensitivities of the other predictive indexes ( p < 0.05). A pre-operative serum α-fetoprotein level ≥400 ng/mL, tumor diameter ≥5 cm and “fast wash-out” enhancement pattern are independent risk factors for ER of HCC after surgical resection. In addition, the “fast wash-out” enhancement pattern could probably be used to screen populations at high risk of recurrence owing to its high sensitivity in predicting ER of HCC post-operatively. All these findings provide beneficial information for management of HCC.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>26803390</pmid><doi>10.1016/j.ultrasmedbio.2015.12.010</doi><tpages>7</tpages></addata></record> |
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| subjects | Age Distribution Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - surgery China - epidemiology Contrast Media Contrast-enhanced ultrasound Early Detection of Cancer - methods Female Hepatocellular carcinoma Humans Image Enhancement - methods Incidence Liver Neoplasms - diagnostic imaging Liver Neoplasms - epidemiology Liver Neoplasms - surgery Male Middle Aged Neoplasm Recurrence, Local - diagnostic imaging Neoplasm Recurrence, Local - epidemiology Neoplasm Recurrence, Local - prevention & control Phospholipids Prognosis Radiology Recurrence Reproducibility of Results Retrospective Studies Risk Assessment - methods Risk factor Sensitivity and Specificity Sex Distribution Sulfur Hexafluoride Treatment Outcome Tumor Burden Ultrasonography - methods Ultrasonography - statistics & numerical data Ultrasound |
| title | Predictive Value of Conventional Ultrasound and Contrast-Enhanced Ultrasound in Early Recurrence of Hepatocellular Carcinoma after Surgical Resection |
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