Intracerebroventricular delivery of self-complementary adeno-associated virus serotype 9 to the adult rat brain

Gene therapy for the central nervous system is poised to become a powerful treatment for numerous neurological disorders. Adeno-associated viral vectors based on serotype 9 (AAV9) have proven themselves to be strong candidates for delivering gene-based therapies throughout the brain and spinal cord...

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Veröffentlicht in:	Gene therapy 2016-05, Vol.23 (5), p.401-407
Hauptverfasser:	Donsante, A, McEachin, Z, Riley, J, Leung, C H, Kanz, L, O'Connor, D M, Boulis, N M
Format:	Artikel
Sprache:	eng
Schlagworte:	42/44 631/378 631/61/201 631/61/2300/1514 692/617/375 82/51 Adeno-associated virus Animal models Animals Astrocytes Astrocytes - metabolism Biomedical and Life Sciences Biomedicine Brain Brain research Care and treatment Cell Biology Central nervous system Central nervous system diseases Cerebellum Cerebellum - metabolism Cerebral cortex Cerebral Cortex - metabolism Clinical trials Dependovirus - genetics Dependoviruses Dosage Drug delivery systems Drugs Gene Expression Gene Therapy Gene Transfer Techniques Genetic Therapy Genetic Vectors Gliosis Gliosis - genetics Hippocampus - metabolism Human Genetics Humans Infusions, Intraventricular Innovations Methods Mice Nanotechnology Neonates Nervous system Neurological diseases Neurological disorders Neurons - metabolism original-article Physiological aspects Rats Rodents Serogroup Signal transduction Spinal cord Swine Transduction Transduction, Genetic Vehicles
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