Antischistosomal activity of N,N′-arylurea analogs against Schistosoma japonicum

The IC50s of seven potent N,N′-arylurea compounds against juvenile and adult S. japonicum. Compounds 16 and 38 showed higher activities than the positive control MMV665852. [Display omitted] Although the antischistosomal activities of N,N′-arylurea analogs were reported, systematic structure–activit...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2016-03, Vol.26 (5), p.1386-1390
Hauptverfasser:	Yao, Houzong, Liu, Fengyou, Chen, Jinglei, Li, Yan, Cui, Jinhao, Qiao, Chunhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antischistosomal agents Dose-Response Relationship, Drug Mice model Molecular Structure N,N′-Arylurea analogs Schistosoma japonicum Schistosoma japonicum - drug effects Schistosomicides - chemical synthesis Schistosomicides - chemistry Schistosomicides - pharmacology Structure-Activity Relationship Urea - analogs & derivatives Urea - chemistry Urea - pharmacology
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