Emodin suppresses LPS-induced inflammation in RAW264.7 cells through a PPARγ-dependent pathway

Inflammation is a defense and protective response to multiple harmful stimuli. Over and uncontrolled inflammation can lead to local tissues or even systemic damages and injuries. Actually, uncontrolled and self-amplified inflammation is the fundament of the pathogenesis of a variety of inflammatory...

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Veröffentlicht in:	International immunopharmacology 2016-05, Vol.34, p.16-24
Hauptverfasser:	Zhu, Tao, Zhang, Wei, Feng, She-jun, Yu, Hua-peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitum - immunology Animals Anti-Inflammatory Agents - pharmacology Disease Models, Animal Emodin Emodin - pharmacology Humans Inflammation Inflammation - drug therapy Lipopolysaccharides - immunology Macrophages - drug effects Macrophages - immunology Mice NF-kappa B - metabolism Nuclear factor-κB (NF-κB) Peroxisome proliferators-activated receptor γ (PPARγ) PPAR gamma - genetics PPAR gamma - metabolism RAW 264.7 Cells RAW264.7 cells Respiratory Distress Syndrome, Adult - drug therapy RNA, Small Interfering - genetics Signal Transduction - drug effects Signal Transduction - genetics
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