Conserved aromatic residues as determinants in the folding and assembly of immunoglobulin variable domains

•Immunoglobulin VH and VL domains exhibit both shared and unique sites of conservation.•Ig heavy- and light-chains share critical sites of conserved aromaticity.•Conserved aromaticity is symmetrically concentrated in the VH–VL interface.•A role for aromaticity in both the folding and assembly of ant...

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