The Effects of the Organic Flame-Retardant 1,2-Dibromo-4-(1,2-dibromoethyl) Cyclohexane (TBECH) on Androgen Signaling in Human Prostate Cancer Cell Lines

ABSTRACT The effects of the organic flame retardant 1,2‐Dibromo‐4‐(1,2‐dibromoethyl) cyclohexane (TBECH) on androgen receptor target gene expression were examined in the human LNCaP prostate cancer cell line. While γ‐/δ‐TBECH alone led to a significant increase in prostate‐specific antigen (PSA) mRN...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2016-05, Vol.30 (5), p.239-242
Hauptverfasser:	Wong, Lilian I. L., Reers, Alexandra R., Currier, Heidi A., Williams, Tony D., Cox, Michael E., Elliott, John E., Beischlag, Timothy V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Receptor Androgens Cell Line, Tumor Cyclohexanes - pharmacology Endocrine Disruptor Endocrine Disruptors - pharmacology Environmental Pollutants - pharmacology Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism Flame Retardants - pharmacology Gene expression Gene Expression Regulation Humans Kallikreins - genetics Kallikreins - metabolism LNCaP Male Organic Flame Retardant Prostate - cytology Prostate - drug effects Prostate - metabolism Prostate cancer Prostate-Specific Antigen - genetics Prostate-Specific Antigen - metabolism Receptors, Androgen - genetics Receptors, Androgen - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction - drug effects Signal Transduction - genetics Stereoisomerism
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