Age-dependent expression of VEGFR2 in deep brain arteries in small vessel disease, CADASIL and healthy brains
Abstract Vascular myocytes are central to brain aging. Small vessel disease (SVD; arteriolosclerosis) is a widespread cause of lacunar stroke and vascular dementia, and is characterised by fibrosis and depletion of vascular myocytes in small penetrating arteries. Vascular endothelial growth factor (...
Gespeichert in:
| Veröffentlicht in: | Neurobiology of aging 2016-06, Vol.42, p.110-115 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 115 |
|---|---|
| container_issue | |
| container_start_page | 110 |
| container_title | Neurobiology of aging |
| container_volume | 42 |
| creator | Ahmed-Jushuf, Fiyyaz, MBBS Jiwa, Nadim S., MBBS Arwani, Anum S., BSc Foot, Peter Bridges, Leslie R., FRCPath Kalaria, Rajesh N., FRCPath Esiri, Margaret M., FRCPath Hainsworth, Atticus H., PhD |
| description | Abstract Vascular myocytes are central to brain aging. Small vessel disease (SVD; arteriolosclerosis) is a widespread cause of lacunar stroke and vascular dementia, and is characterised by fibrosis and depletion of vascular myocytes in small penetrating arteries. Vascular endothelial growth factor (VEGF) is associated with brain aging, and VEGFR2 is a potent determinant of cell fate. Here, we tested whether VEGFR2 in vascular myocytes is associated with older age and SVD in human brain. VEGFR2 immunolabelling in deep grey matter was assessed in older people with or without moderate-severe SVD, or in younger people without brain pathology or with a monogenic form of SVD (CADASIL). All cases were without Alzheimer’s disease pathology. Myocyte VEGFR2 was associated with increasing age (p=0.0026) but not with SVD pathology or with sclerotic index or blood vessel density. We conclude that VEGFR2 is consistently expressed in small artery myocytes of older people, and may mediate effects of VEGF on brain vascular aging. |
| doi_str_mv | 10.1016/j.neurobiolaging.2016.03.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1790959917</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0197458016002001</els_id><sourcerecordid>1790959917</sourcerecordid><originalsourceid>FETCH-LOGICAL-c528t-9c1a9c5058373cf1cfa77c94b981678718f4969dc0b93418e9020aab1b4395cd3</originalsourceid><addsrcrecordid>eNqNkk1v1DAQhi0EokvhLyAfOHAgYZwvxxJCWi3dttJKSBS4Wo492XpxnNROKvbfN9EWJDj1ZGv0vDPSPEPIOwYpA1Z9PKQep9A3tndqb_0-zeZqCnkKkD0jK1aWdcIKwZ-TFTDBk6Ks4Yy8ivEAALzg1UtylnFW5EXGV6Rb7zExOKA36EeKv4eAMdre076lPy8ut98yaj01iANtgpq_KowYLMalHDvlHL2fE-iosRFVxA90s_6yvrneUeUNvUXlxtvjKRtfkxetchHfPL7n5Mf24vvmKtl9vbzerHeJLrN6TIRmSugSyjrnuW6ZbhXnWhSNqFnFa87qthCVMBoakResRgEZKNWwpshFqU1-Tt6f-g6hv5swjrKzUaNzymM_Rcm4AFEKwfgT0JqDyKpczOinE6pDH2PAVg7BdiocJQO5uJEH-a8bubiRkMvZzRx_-zhpajo0f8N_ZMzA9gTgvJp7i0FGbdFrNDagHqXp7VMnff6vkXbWW63cLzxiPPRT8PP6JZMxkyBvljtZzoRVcxqA5Q8UkbwF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1787092639</pqid></control><display><type>article</type><title>Age-dependent expression of VEGFR2 in deep brain arteries in small vessel disease, CADASIL and healthy brains</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Ahmed-Jushuf, Fiyyaz, MBBS ; Jiwa, Nadim S., MBBS ; Arwani, Anum S., BSc ; Foot, Peter ; Bridges, Leslie R., FRCPath ; Kalaria, Rajesh N., FRCPath ; Esiri, Margaret M., FRCPath ; Hainsworth, Atticus H., PhD</creator><creatorcontrib>Ahmed-Jushuf, Fiyyaz, MBBS ; Jiwa, Nadim S., MBBS ; Arwani, Anum S., BSc ; Foot, Peter ; Bridges, Leslie R., FRCPath ; Kalaria, Rajesh N., FRCPath ; Esiri, Margaret M., FRCPath ; Hainsworth, Atticus H., PhD</creatorcontrib><description>Abstract Vascular myocytes are central to brain aging. Small vessel disease (SVD; arteriolosclerosis) is a widespread cause of lacunar stroke and vascular dementia, and is characterised by fibrosis and depletion of vascular myocytes in small penetrating arteries. Vascular endothelial growth factor (VEGF) is associated with brain aging, and VEGFR2 is a potent determinant of cell fate. Here, we tested whether VEGFR2 in vascular myocytes is associated with older age and SVD in human brain. VEGFR2 immunolabelling in deep grey matter was assessed in older people with or without moderate-severe SVD, or in younger people without brain pathology or with a monogenic form of SVD (CADASIL). All cases were without Alzheimer’s disease pathology. Myocyte VEGFR2 was associated with increasing age (p=0.0026) but not with SVD pathology or with sclerotic index or blood vessel density. We conclude that VEGFR2 is consistently expressed in small artery myocytes of older people, and may mediate effects of VEGF on brain vascular aging.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2016.03.002</identifier><identifier>PMID: 27143427</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Aging ; Arteriolosclerosis ; Arteriosclerosis - genetics ; Arteriosclerosis - metabolism ; CADASIL - genetics ; CADASIL - metabolism ; Cerebral Arteries - cytology ; Cerebral Arteries - metabolism ; Female ; Flk-1 ; Gene Expression ; Humans ; Internal Medicine ; Male ; Muscle Cells - metabolism ; Neurology ; Small vessel disease ; Vascular dementia ; Vascular Endothelial Growth Factor Receptor-2 - genetics ; Vascular Endothelial Growth Factor Receptor-2 - metabolism ; Vasculopathy</subject><ispartof>Neurobiology of aging, 2016-06, Vol.42, p.110-115</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-9c1a9c5058373cf1cfa77c94b981678718f4969dc0b93418e9020aab1b4395cd3</citedby><cites>FETCH-LOGICAL-c528t-9c1a9c5058373cf1cfa77c94b981678718f4969dc0b93418e9020aab1b4395cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0197458016002001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27143427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmed-Jushuf, Fiyyaz, MBBS</creatorcontrib><creatorcontrib>Jiwa, Nadim S., MBBS</creatorcontrib><creatorcontrib>Arwani, Anum S., BSc</creatorcontrib><creatorcontrib>Foot, Peter</creatorcontrib><creatorcontrib>Bridges, Leslie R., FRCPath</creatorcontrib><creatorcontrib>Kalaria, Rajesh N., FRCPath</creatorcontrib><creatorcontrib>Esiri, Margaret M., FRCPath</creatorcontrib><creatorcontrib>Hainsworth, Atticus H., PhD</creatorcontrib><title>Age-dependent expression of VEGFR2 in deep brain arteries in small vessel disease, CADASIL and healthy brains</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Abstract Vascular myocytes are central to brain aging. Small vessel disease (SVD; arteriolosclerosis) is a widespread cause of lacunar stroke and vascular dementia, and is characterised by fibrosis and depletion of vascular myocytes in small penetrating arteries. Vascular endothelial growth factor (VEGF) is associated with brain aging, and VEGFR2 is a potent determinant of cell fate. Here, we tested whether VEGFR2 in vascular myocytes is associated with older age and SVD in human brain. VEGFR2 immunolabelling in deep grey matter was assessed in older people with or without moderate-severe SVD, or in younger people without brain pathology or with a monogenic form of SVD (CADASIL). All cases were without Alzheimer’s disease pathology. Myocyte VEGFR2 was associated with increasing age (p=0.0026) but not with SVD pathology or with sclerotic index or blood vessel density. We conclude that VEGFR2 is consistently expressed in small artery myocytes of older people, and may mediate effects of VEGF on brain vascular aging.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Arteriolosclerosis</subject><subject>Arteriosclerosis - genetics</subject><subject>Arteriosclerosis - metabolism</subject><subject>CADASIL - genetics</subject><subject>CADASIL - metabolism</subject><subject>Cerebral Arteries - cytology</subject><subject>Cerebral Arteries - metabolism</subject><subject>Female</subject><subject>Flk-1</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Muscle Cells - metabolism</subject><subject>Neurology</subject><subject>Small vessel disease</subject><subject>Vascular dementia</subject><subject>Vascular Endothelial Growth Factor Receptor-2 - genetics</subject><subject>Vascular Endothelial Growth Factor Receptor-2 - metabolism</subject><subject>Vasculopathy</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQhi0EokvhLyAfOHAgYZwvxxJCWi3dttJKSBS4Wo492XpxnNROKvbfN9EWJDj1ZGv0vDPSPEPIOwYpA1Z9PKQep9A3tndqb_0-zeZqCnkKkD0jK1aWdcIKwZ-TFTDBk6Ks4Yy8ivEAALzg1UtylnFW5EXGV6Rb7zExOKA36EeKv4eAMdre076lPy8ut98yaj01iANtgpq_KowYLMalHDvlHL2fE-iosRFVxA90s_6yvrneUeUNvUXlxtvjKRtfkxetchHfPL7n5Mf24vvmKtl9vbzerHeJLrN6TIRmSugSyjrnuW6ZbhXnWhSNqFnFa87qthCVMBoakResRgEZKNWwpshFqU1-Tt6f-g6hv5swjrKzUaNzymM_Rcm4AFEKwfgT0JqDyKpczOinE6pDH2PAVg7BdiocJQO5uJEH-a8bubiRkMvZzRx_-zhpajo0f8N_ZMzA9gTgvJp7i0FGbdFrNDagHqXp7VMnff6vkXbWW63cLzxiPPRT8PP6JZMxkyBvljtZzoRVcxqA5Q8UkbwF</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Ahmed-Jushuf, Fiyyaz, MBBS</creator><creator>Jiwa, Nadim S., MBBS</creator><creator>Arwani, Anum S., BSc</creator><creator>Foot, Peter</creator><creator>Bridges, Leslie R., FRCPath</creator><creator>Kalaria, Rajesh N., FRCPath</creator><creator>Esiri, Margaret M., FRCPath</creator><creator>Hainsworth, Atticus H., PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20160601</creationdate><title>Age-dependent expression of VEGFR2 in deep brain arteries in small vessel disease, CADASIL and healthy brains</title><author>Ahmed-Jushuf, Fiyyaz, MBBS ; Jiwa, Nadim S., MBBS ; Arwani, Anum S., BSc ; Foot, Peter ; Bridges, Leslie R., FRCPath ; Kalaria, Rajesh N., FRCPath ; Esiri, Margaret M., FRCPath ; Hainsworth, Atticus H., PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-9c1a9c5058373cf1cfa77c94b981678718f4969dc0b93418e9020aab1b4395cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Arteriolosclerosis</topic><topic>Arteriosclerosis - genetics</topic><topic>Arteriosclerosis - metabolism</topic><topic>CADASIL - genetics</topic><topic>CADASIL - metabolism</topic><topic>Cerebral Arteries - cytology</topic><topic>Cerebral Arteries - metabolism</topic><topic>Female</topic><topic>Flk-1</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Muscle Cells - metabolism</topic><topic>Neurology</topic><topic>Small vessel disease</topic><topic>Vascular dementia</topic><topic>Vascular Endothelial Growth Factor Receptor-2 - genetics</topic><topic>Vascular Endothelial Growth Factor Receptor-2 - metabolism</topic><topic>Vasculopathy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmed-Jushuf, Fiyyaz, MBBS</creatorcontrib><creatorcontrib>Jiwa, Nadim S., MBBS</creatorcontrib><creatorcontrib>Arwani, Anum S., BSc</creatorcontrib><creatorcontrib>Foot, Peter</creatorcontrib><creatorcontrib>Bridges, Leslie R., FRCPath</creatorcontrib><creatorcontrib>Kalaria, Rajesh N., FRCPath</creatorcontrib><creatorcontrib>Esiri, Margaret M., FRCPath</creatorcontrib><creatorcontrib>Hainsworth, Atticus H., PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmed-Jushuf, Fiyyaz, MBBS</au><au>Jiwa, Nadim S., MBBS</au><au>Arwani, Anum S., BSc</au><au>Foot, Peter</au><au>Bridges, Leslie R., FRCPath</au><au>Kalaria, Rajesh N., FRCPath</au><au>Esiri, Margaret M., FRCPath</au><au>Hainsworth, Atticus H., PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-dependent expression of VEGFR2 in deep brain arteries in small vessel disease, CADASIL and healthy brains</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>42</volume><spage>110</spage><epage>115</epage><pages>110-115</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><abstract>Abstract Vascular myocytes are central to brain aging. Small vessel disease (SVD; arteriolosclerosis) is a widespread cause of lacunar stroke and vascular dementia, and is characterised by fibrosis and depletion of vascular myocytes in small penetrating arteries. Vascular endothelial growth factor (VEGF) is associated with brain aging, and VEGFR2 is a potent determinant of cell fate. Here, we tested whether VEGFR2 in vascular myocytes is associated with older age and SVD in human brain. VEGFR2 immunolabelling in deep grey matter was assessed in older people with or without moderate-severe SVD, or in younger people without brain pathology or with a monogenic form of SVD (CADASIL). All cases were without Alzheimer’s disease pathology. Myocyte VEGFR2 was associated with increasing age (p=0.0026) but not with SVD pathology or with sclerotic index or blood vessel density. We conclude that VEGFR2 is consistently expressed in small artery myocytes of older people, and may mediate effects of VEGF on brain vascular aging.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27143427</pmid><doi>10.1016/j.neurobiolaging.2016.03.002</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0197-4580 |
| ispartof | Neurobiology of aging, 2016-06, Vol.42, p.110-115 |
| issn | 0197-4580 1558-1497 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1790959917 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Aged, 80 and over Aging Arteriolosclerosis Arteriosclerosis - genetics Arteriosclerosis - metabolism CADASIL - genetics CADASIL - metabolism Cerebral Arteries - cytology Cerebral Arteries - metabolism Female Flk-1 Gene Expression Humans Internal Medicine Male Muscle Cells - metabolism Neurology Small vessel disease Vascular dementia Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - metabolism Vasculopathy |
| title | Age-dependent expression of VEGFR2 in deep brain arteries in small vessel disease, CADASIL and healthy brains |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T23%3A31%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Age-dependent%20expression%20of%20VEGFR2%20in%20deep%20brain%20arteries%20in%20small%20vessel%20disease,%20CADASIL%20and%20healthy%20brains&rft.jtitle=Neurobiology%20of%20aging&rft.au=Ahmed-Jushuf,%20Fiyyaz,%20MBBS&rft.date=2016-06-01&rft.volume=42&rft.spage=110&rft.epage=115&rft.pages=110-115&rft.issn=0197-4580&rft.eissn=1558-1497&rft_id=info:doi/10.1016/j.neurobiolaging.2016.03.002&rft_dat=%3Cproquest_cross%3E1790959917%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1787092639&rft_id=info:pmid/27143427&rft_els_id=S0197458016002001&rfr_iscdi=true |