Activation of inflammasomes in dendritic cells and macrophages by Mycoplasma salivarium

Summary Interleukin‐1β (IL‐1β) plays crucial roles in the pathogenesis of periodontal disease. It is produced after the processing of pro‐IL‐1β by caspase‐1, which is activated by the inflammasome‐a multiprotein complex comprising nucleotide‐binding domain leucine‐rich repeat‐containing receptor (NL...

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Veröffentlicht in:	Molecular oral microbiology 2016-06, Vol.31 (3), p.259-269
Hauptverfasser:	Sugiyama, M., Saeki, A., Hasebe, A., Kamesaki, R., Yoshida, Y., Kitagawa, Y., Suzuki, T., Shibata, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Regulatory Proteins - deficiency CARD Signaling Adaptor Proteins Caspase 1 - deficiency Dendritic Cells - immunology Dentistry Female Humans inflammasome Inflammasomes - immunology Interleukin-1beta - biosynthesis Interleukin-1beta - immunology interleukin-1β Macrophages - immunology Male Mycoplasma pneumoniae Mycoplasma pneumoniae - immunology Mycoplasma salivarium Mycoplasma salivarium - immunology NLR Family, Pyrin Domain-Containing 3 Protein - deficiency nucleotide-binding domain leucine-rich repeat-containing receptor-containing protein 3 Periodontal Diseases - microbiology Pyroptosis Signal Transduction
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