MicroRNA–21 as a novel biomarker in diagnosis and response to therapy in asthmatic children

•expression levels of miRNA-21 were higher in the asthmatic children.•IL12 p35 levels were significantly decreased in asthmatic patients.•serum miRNA-21 expression was correlated with serum IL12 p35 levels and FEV1.•miRNA-21 has differentiates ICS sensitive from ICS resistant. The underlying molecul...

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Veröffentlicht in:	Molecular immunology 2016-03, Vol.71, p.107-114
Hauptverfasser:	Elbehidy, Rabab M., Youssef, Doaa M., El-Shal, Amal S., Shalaby, Sally M., Sherbiny, Hanan S., Sherief, Laila M., Akeel, Nagwa E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones - therapeutic use Area Under Curve Asthma Asthma - drug therapy Asthma - genetics Biomarkers - blood Child Enzyme-Linked Immunosorbent Assay Female Humans Interleukin-12 Subunit p35 - blood Male MicroRNAs - blood miRNA miRNA -21 Real-Time Polymerase Chain Reaction Respiratory Function Tests ROC Curve Sensitivity and Specificity Steroid therapy
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