Monotherapy with Levetiracetam Versus Older AEDs: A Randomized Comparative Trial of Effects on Bone Health

Long-term anti-epileptic drug (AED) therapy is associated with increased fracture risk. This study tested whether substituting the newer AED levetiracetam has less adverse effects on bone than older AEDs. An open-label randomized comparative trial. Participants had “failed” initial monotherapy for p...

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Veröffentlicht in:	Calcified tissue international 2016-06, Vol.98 (6), p.556-565
Hauptverfasser:	Hakami, Tahir, O’Brien, Terence J., Petty, Sandra J., Sakellarides, Mary, Christie, Jemma, Kantor, Susan, Todaro, Marian, Gorelik, Alexandra, Seibel, Markus J., Yerra, Raju, Wark, John D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptiometry, Photon Adult Aged Anticonvulsants - adverse effects Biochemistry Biomedical and Life Sciences Bone and Bones - drug effects Bone Density - drug effects Bone Remodeling - drug effects Carbamazepine - adverse effects Cell Biology Drug therapy Endocrinology Epilepsy Epilepsy - drug therapy Female Fractures Humans Life Sciences Male Middle Aged Original Research Orthopedics Piracetam - adverse effects Piracetam - analogs & derivatives Studies Tomography, X-Ray Computed Valproic Acid - adverse effects
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