Carbohydrate-based inducers of cellular stress for targeting cancer cells

[Display omitted] Small molecules that block the altered metabolism in cancer or increase the production of reactive oxygen species (ROS) are emerging as potential anti-cancer agents. Considering that various carbohydrates can be used for cellular energetics or protein N-glycosylation of which inter...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2016-03, Vol.26 (5), p.1452-1456
Hauptverfasser:	Ndombera, Fidelis T., VanHecke, Garrett C., Nagi, Shima, Ahn, Young-Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Deoxy-d-glucose Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cytotoxicity Dose-Response Relationship, Drug Glycosides - chemical synthesis Glycosides - chemistry Glycosides - pharmacology HEK293 Cells Humans Molecular Structure N-Aryl glycoside library Reactive Oxygen Species - metabolism Reactive oxygen species inducer Stress, Physiological - drug effects Structure-Activity Relationship
Online-Zugang:	Volltext
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