Postpartum estrogen withdrawal impairs hippocampal neurogenesis and causes depression- and anxiety-like behaviors in mice

Highlights • Estrogen withdrawal (EW) after HSP induced depression and anxiety behaviors in mice. • Survival of mature newborn neurons in hippocampal DG was impaired by EW after HSP. • EW after HSP reduces hippocampal Src activity to suppress NR2B phosphorylation. • NMDAr agonist could reduce the lo...

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Veröffentlicht in:	Psychoneuroendocrinology 2016-04, Vol.66, p.138-149
Hauptverfasser:	Zhang, Zhuan, Hong, Juan, Zhang, Suyun, Zhang, Tingting, Sha, Sha, Yang, Rong, Qian, Yanning, Chen, Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Anxiety - etiology Anxiety - metabolism Behavior, Animal - drug effects Brain-derived neurotrophic factor (BDNF) Depression - etiology Depression - metabolism Endocrinology & Metabolism Estradiol - deficiency Estradiol - pharmacology Estradiol benzoate (EB) Female Hippocampus - cytology Hippocampus - drug effects Hormone-simulated pregnancy (HSP) Mice Mice, Inbred ICR Neurogenesis Neurogenesis - drug effects Neurons - drug effects Neurons - physiology NMDA receptor (NMDAr) Ovariectomy - adverse effects Ovariectomy - psychology Postpartum depression (PPD) Postpartum Period - drug effects Postpartum Period - physiology Postpartum Period - psychology Pregnancy Psychiatry
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Zusammenfassung:	Highlights • Estrogen withdrawal (EW) after HSP induced depression and anxiety behaviors in mice. • Survival of mature newborn neurons in hippocampal DG was impaired by EW after HSP. • EW after HSP reduces hippocampal Src activity to suppress NR2B phosphorylation. • NMDAr agonist could reduce the loss of newborn neurons after EW of HSP. • NMDAr agonist improved depression- and anxiety-like behaviors after EW of HSP.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2016.01.013