An iminosugar-based heparanase inhibitor heparastatin (SF4) suppresses infiltration of neutrophils and monocytes into inflamed dorsal air pouches

Local infiltration of inflammatory cells is regulated by a number of biological steps during which the cells likely penetrate through subendothelial basement membranes that contain heparan sulfate proteoglycans. In the present study, we examined whether administration of heparastatin (SF4), an imino...

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Veröffentlicht in:	International immunopharmacology 2016-06, Vol.35, p.15-21
Hauptverfasser:	Sue, Mayumi, Higashi, Nobuaki, Shida, Hiroaki, Kogane, Yusuke, Nishimura, Yoshio, Adachi, Hayamitsu, Kolaczkowska, Elzbieta, Kepka, Magdalena, Nakajima, Motowo, Irimura, Tatsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basement Membrane - drug effects Carrageenan - immunology Cell Movement - drug effects Cells, Cultured Chemokines Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - therapeutic use Extracellular matrix Glucuronidase - antagonists & inhibitors Heparanase Heparastatin (SF4) Heparitin Sulfate - metabolism Humans Imino Sugars - chemical synthesis Imino Sugars - therapeutic use Inflammation - drug therapy Inflammation - immunology Male Mice Mice, Inbred C57BL Models, Animal Monocytes - drug effects Monocytes - physiology N-Formylmethionine Leucyl-Phenylalanine - immunology Neutrophils - drug effects Neutrophils - physiology Nipecotic Acids - chemical synthesis Nipecotic Acids - therapeutic use
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