Randomized phase II study of axitinib versus physicians best alternative choice of therapy in patients with recurrent glioblastoma

We conducted a randomized, non-comparative, multi center, phase II clinical trial in order to investigate the efficacy of axitinib, an oral small molecule tyrosine kinase inhibitor with high affinity and specificity for the vascular endothelial growth factor receptors, in patients with recurrent gli...

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Veröffentlicht in:	Journal of neuro-oncology 2016-05, Vol.128 (1), p.147-155
Hauptverfasser:	Duerinck, J., Du Four, S., Vandervorst, F., D’Haene, N., Le Mercier, M., Michotte, A., Van Binst, A. M., Everaert, H., Salmon, I., Bouttens, F., Verschaeve, V., Neyns, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Angiogenesis Inhibitors - adverse effects Angiogenesis Inhibitors - therapeutic use Antineoplastic Agents, Alkylating - therapeutic use Bevacizumab - therapeutic use Brain Neoplasms - diagnostic imaging Brain Neoplasms - drug therapy Brain Neoplasms - genetics Clinical Study Disease-Free Survival Female Fluorodeoxyglucose F18 Glioblastoma - diagnostic imaging Glioblastoma - drug therapy Glioblastoma - genetics Humans Imidazoles - adverse effects Imidazoles - therapeutic use Indazoles - adverse effects Indazoles - therapeutic use Lomustine - therapeutic use Male Medicine Medicine & Public Health Middle Aged Neoplasm Recurrence, Local - diagnostic imaging Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - genetics Neurology Oncology Positron-Emission Tomography Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use Protein-Tyrosine Kinases - antagonists & inhibitors Radiopharmaceuticals Steroids - therapeutic use Treatment Outcome Young Adult
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