Silver nanoparticles: A new view on mechanistic aspects on antimicrobial activity
Abstract Silver nanoparticles are well known potent antimicrobial agents. Although significant progresses have been achieved on the elucidation of antimicrobial mechanism of silver nanoparticles, the exact mechanism of action is still not completely known. This overview incorporates a retrospective...
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| Veröffentlicht in: | Nanomedicine 2016-04, Vol.12 (3), p.789-799 |
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| creator | Durán, Nelson Durán, Marcela de Jesus, Marcelo Bispo Seabra, Amedea B Fávaro, Wagner J Nakazato, Gerson |
| description | Abstract Silver nanoparticles are well known potent antimicrobial agents. Although significant progresses have been achieved on the elucidation of antimicrobial mechanism of silver nanoparticles, the exact mechanism of action is still not completely known. This overview incorporates a retrospective of previous reviews published and recent original contributions on the progress of research on antimicrobial mechanisms of silver nanoparticles. The main topics discussed include release of silver nanoparticles and silver ions, cell membrane damage, DNA interaction, free radical generation, bacterial resistance and the relationship of resistance to silver ions versus resistance to silver nanoparticles. The focus of the overview is to summarize the current knowledge in the field of antibacterial activity of silver nanoparticles. The possibility that pathogenic microbes may develop resistance to silver nanoparticles is also discussed. |
| doi_str_mv | 10.1016/j.nano.2015.11.016 |
| format | Article |
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Although significant progresses have been achieved on the elucidation of antimicrobial mechanism of silver nanoparticles, the exact mechanism of action is still not completely known. This overview incorporates a retrospective of previous reviews published and recent original contributions on the progress of research on antimicrobial mechanisms of silver nanoparticles. The main topics discussed include release of silver nanoparticles and silver ions, cell membrane damage, DNA interaction, free radical generation, bacterial resistance and the relationship of resistance to silver ions versus resistance to silver nanoparticles. The focus of the overview is to summarize the current knowledge in the field of antibacterial activity of silver nanoparticles. 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Although significant progresses have been achieved on the elucidation of antimicrobial mechanism of silver nanoparticles, the exact mechanism of action is still not completely known. This overview incorporates a retrospective of previous reviews published and recent original contributions on the progress of research on antimicrobial mechanisms of silver nanoparticles. The main topics discussed include release of silver nanoparticles and silver ions, cell membrane damage, DNA interaction, free radical generation, bacterial resistance and the relationship of resistance to silver ions versus resistance to silver nanoparticles. The focus of the overview is to summarize the current knowledge in the field of antibacterial activity of silver nanoparticles. 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| subjects | Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial Bacteria - drug effects Bacteria - genetics Bacteria - growth & development Bacteria - metabolism Bacterial Infections - drug therapy Bacterial Infections - microbiology Bacterial Proteins - metabolism Bacterial resistance DNA Damage - drug effects DNA, Bacterial - genetics Drug Resistance, Bacterial Free Radicals - metabolism Humans Internal Medicine Lipid Metabolism - drug effects Metal Nanoparticles - chemistry Silver - chemistry Silver - pharmacology Silver nanoparticles Toxicity |
| title | Silver nanoparticles: A new view on mechanistic aspects on antimicrobial activity |
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