Genetically predicted 17beta-estradiol and cardiovascular risk factors in women: a Mendelian randomization analysis using young women in Hong Kong and older women in the Guangzhou Biobank Cohort Study
Abstract Purpose The role of estrogen in cardiovascular health remains contested with discrepancies between findings from randomized controlled trials and observational studies. Mendelian randomization, which assesses the effect of lifelong endogenous exposure, may help elucidate these discrepancies...
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| Veröffentlicht in: | Annals of epidemiology 2016-03, Vol.26 (3), p.171-175 |
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| creator | Au Yeung, Shiu Lun, PhD Cheng, Kar Keung, PhD Zhao, Jie, PhD Zhang, Weisen, MD Jiang, Chaoqiang, MD Lam, Tai Hing, MD Leung, Gabriel Matthew, MD Schooling, C. Mary, PhD |
| description | Abstract Purpose The role of estrogen in cardiovascular health remains contested with discrepancies between findings from randomized controlled trials and observational studies. Mendelian randomization, which assesses the effect of lifelong endogenous exposure, may help elucidate these discrepancies. Methods We used separate sample instrumental variable analysis to estimate the association of log 17β-estradiol with factors related to cardiovascular disease risk (systolic and diastolic blood pressure, lipids, fasting glucose, body mass index, waist hip ratio, and waist circumference) and Framingham score, a predictor of 10-year risk of ischemic heart disease events, in older Chinese women from the Guangzhou Biobank Cohort Study (GBCS, n = 3092). The estimate was derived using the Wald estimator, that is, the ratio of the association of genetic determinants (rs1008805 and rs2175898) of log 17β-estradiol with cardiovascular disease risk factors and Framingham score in GBCS and the association of these genetic determinants with log 17β-estradiol in a sample of young women from Hong Kong ( n = 236). Results Genetically, higher 17β-estradiol was not associated with any cardiovascular disease-related risk factor or with Framingham score (−0.01, 95% confidence interval = −1.34 to 1.31). Conclusions Lifetime exposure to estrogen does not appear to be cardioprotective via the cardiovascular disease-related risk factors examined. |
| doi_str_mv | 10.1016/j.annepidem.2016.01.005 |
| format | Article |
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Mary, PhD</creator><creatorcontrib>Au Yeung, Shiu Lun, PhD ; Cheng, Kar Keung, PhD ; Zhao, Jie, PhD ; Zhang, Weisen, MD ; Jiang, Chaoqiang, MD ; Lam, Tai Hing, MD ; Leung, Gabriel Matthew, MD ; Schooling, C. Mary, PhD</creatorcontrib><description>Abstract Purpose The role of estrogen in cardiovascular health remains contested with discrepancies between findings from randomized controlled trials and observational studies. Mendelian randomization, which assesses the effect of lifelong endogenous exposure, may help elucidate these discrepancies. Methods We used separate sample instrumental variable analysis to estimate the association of log 17β-estradiol with factors related to cardiovascular disease risk (systolic and diastolic blood pressure, lipids, fasting glucose, body mass index, waist hip ratio, and waist circumference) and Framingham score, a predictor of 10-year risk of ischemic heart disease events, in older Chinese women from the Guangzhou Biobank Cohort Study (GBCS, n = 3092). The estimate was derived using the Wald estimator, that is, the ratio of the association of genetic determinants (rs1008805 and rs2175898) of log 17β-estradiol with cardiovascular disease risk factors and Framingham score in GBCS and the association of these genetic determinants with log 17β-estradiol in a sample of young women from Hong Kong ( n = 236). Results Genetically, higher 17β-estradiol was not associated with any cardiovascular disease-related risk factor or with Framingham score (−0.01, 95% confidence interval = −1.34 to 1.31). Conclusions Lifetime exposure to estrogen does not appear to be cardioprotective via the cardiovascular disease-related risk factors examined.</description><identifier>ISSN: 1047-2797</identifier><identifier>EISSN: 1873-2585</identifier><identifier>DOI: 10.1016/j.annepidem.2016.01.005</identifier><identifier>PMID: 26907540</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - metabolism ; Cardiovascular risk factors ; China - epidemiology ; Chinese ; Cohort Studies ; Estradiol - genetics ; Estradiol - metabolism ; Estrogen ; Female ; Genetic Markers ; Hong Kong - epidemiology ; Humans ; Internal Medicine ; Mendelian Randomization Analysis ; Middle Aged ; Polymorphism, Single Nucleotide ; Risk Factors ; Women ; Young Adult</subject><ispartof>Annals of epidemiology, 2016-03, Vol.26 (3), p.171-175</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c644t-187534ca2a2057f3adf318ee8a9ffac6cc906468f8855858eef686204bfa55243</citedby><cites>FETCH-LOGICAL-c644t-187534ca2a2057f3adf318ee8a9ffac6cc906468f8855858eef686204bfa55243</cites><orcidid>0000-0001-9933-5887</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.annepidem.2016.01.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26907540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Au Yeung, Shiu Lun, PhD</creatorcontrib><creatorcontrib>Cheng, Kar Keung, PhD</creatorcontrib><creatorcontrib>Zhao, Jie, PhD</creatorcontrib><creatorcontrib>Zhang, Weisen, MD</creatorcontrib><creatorcontrib>Jiang, Chaoqiang, MD</creatorcontrib><creatorcontrib>Lam, Tai Hing, MD</creatorcontrib><creatorcontrib>Leung, Gabriel Matthew, MD</creatorcontrib><creatorcontrib>Schooling, C. Mary, PhD</creatorcontrib><title>Genetically predicted 17beta-estradiol and cardiovascular risk factors in women: a Mendelian randomization analysis using young women in Hong Kong and older women in the Guangzhou Biobank Cohort Study</title><title>Annals of epidemiology</title><addtitle>Ann Epidemiol</addtitle><description>Abstract Purpose The role of estrogen in cardiovascular health remains contested with discrepancies between findings from randomized controlled trials and observational studies. Mendelian randomization, which assesses the effect of lifelong endogenous exposure, may help elucidate these discrepancies. Methods We used separate sample instrumental variable analysis to estimate the association of log 17β-estradiol with factors related to cardiovascular disease risk (systolic and diastolic blood pressure, lipids, fasting glucose, body mass index, waist hip ratio, and waist circumference) and Framingham score, a predictor of 10-year risk of ischemic heart disease events, in older Chinese women from the Guangzhou Biobank Cohort Study (GBCS, n = 3092). The estimate was derived using the Wald estimator, that is, the ratio of the association of genetic determinants (rs1008805 and rs2175898) of log 17β-estradiol with cardiovascular disease risk factors and Framingham score in GBCS and the association of these genetic determinants with log 17β-estradiol in a sample of young women from Hong Kong ( n = 236). Results Genetically, higher 17β-estradiol was not associated with any cardiovascular disease-related risk factor or with Framingham score (−0.01, 95% confidence interval = −1.34 to 1.31). Conclusions Lifetime exposure to estrogen does not appear to be cardioprotective via the cardiovascular disease-related risk factors examined.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Cardiovascular Diseases - metabolism</subject><subject>Cardiovascular risk factors</subject><subject>China - epidemiology</subject><subject>Chinese</subject><subject>Cohort Studies</subject><subject>Estradiol - genetics</subject><subject>Estradiol - metabolism</subject><subject>Estrogen</subject><subject>Female</subject><subject>Genetic Markers</subject><subject>Hong Kong - epidemiology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Mendelian Randomization Analysis</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk Factors</subject><subject>Women</subject><subject>Young Adult</subject><issn>1047-2797</issn><issn>1873-2585</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk1v1DAQjRCIlsJfAB-5JPgjjhMOSGUFW0QRh8LZmnUmXe8m9mInRekv5GfhsKVInHoZf8x7M5r3JsteMVowyqo3uwKcw4NtcSh4-igoKyiVj7JTViuRc1nLx-lOS5Vz1aiT7FmMO0qpqhV_mp3wqqFKlvQ0-7VGh6M10PczOQRsrRmxJUxtcIQc4xigtb4n4FpiIKT7DUQz9RBIsHFPOjCjD5FYR376Ad1bAuQLuhZ7C46ERPODvYXRepdqQD9HG8kUrbsms59S_MNa6Bc-vT4vYenl-xbDv-S4RbKewF3fbv1E3lu_AbcnK7_1YSRX49TOz7MnHfQRX9ydZ9n3jx--rS7yy6_rT6vzy9xUZTnmSR4pSgMcOJWqE9B2gtWINTRdmqUypqFVWdVdXcskYsp0VV1xWm46kJKX4ix7fax7CP7HlATSg40G-x4c-ilqphrayJI34gFQVUrBuGgSVB2hJvgYA3b6EOwAYdaM6sVxvdP3juvFcU2ZTo4n5su7JtNmwPae99fiBDg_AjCpcmMx6GgsOpOsDmhG3Xr7gCbv_qtheuuWrdnjjHHnp5C8TRPpyDXVV8viLXvHKkGpqBrxG98m2dw</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Au Yeung, Shiu Lun, PhD</creator><creator>Cheng, Kar Keung, PhD</creator><creator>Zhao, Jie, PhD</creator><creator>Zhang, Weisen, MD</creator><creator>Jiang, Chaoqiang, MD</creator><creator>Lam, Tai Hing, MD</creator><creator>Leung, Gabriel Matthew, MD</creator><creator>Schooling, C. Mary, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope><orcidid>https://orcid.org/0000-0001-9933-5887</orcidid></search><sort><creationdate>20160301</creationdate><title>Genetically predicted 17beta-estradiol and cardiovascular risk factors in women: a Mendelian randomization analysis using young women in Hong Kong and older women in the Guangzhou Biobank Cohort Study</title><author>Au Yeung, Shiu Lun, PhD ; Cheng, Kar Keung, PhD ; Zhao, Jie, PhD ; Zhang, Weisen, MD ; Jiang, Chaoqiang, MD ; Lam, Tai Hing, MD ; Leung, Gabriel Matthew, MD ; Schooling, C. Mary, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c644t-187534ca2a2057f3adf318ee8a9ffac6cc906468f8855858eef686204bfa55243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular Diseases - genetics</topic><topic>Cardiovascular Diseases - metabolism</topic><topic>Cardiovascular risk factors</topic><topic>China - epidemiology</topic><topic>Chinese</topic><topic>Cohort Studies</topic><topic>Estradiol - genetics</topic><topic>Estradiol - metabolism</topic><topic>Estrogen</topic><topic>Female</topic><topic>Genetic Markers</topic><topic>Hong Kong - epidemiology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Mendelian Randomization Analysis</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk Factors</topic><topic>Women</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Au Yeung, Shiu Lun, PhD</creatorcontrib><creatorcontrib>Cheng, Kar Keung, PhD</creatorcontrib><creatorcontrib>Zhao, Jie, PhD</creatorcontrib><creatorcontrib>Zhang, Weisen, MD</creatorcontrib><creatorcontrib>Jiang, Chaoqiang, MD</creatorcontrib><creatorcontrib>Lam, Tai Hing, MD</creatorcontrib><creatorcontrib>Leung, Gabriel Matthew, MD</creatorcontrib><creatorcontrib>Schooling, C. Mary, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Annals of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Au Yeung, Shiu Lun, PhD</au><au>Cheng, Kar Keung, PhD</au><au>Zhao, Jie, PhD</au><au>Zhang, Weisen, MD</au><au>Jiang, Chaoqiang, MD</au><au>Lam, Tai Hing, MD</au><au>Leung, Gabriel Matthew, MD</au><au>Schooling, C. Mary, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetically predicted 17beta-estradiol and cardiovascular risk factors in women: a Mendelian randomization analysis using young women in Hong Kong and older women in the Guangzhou Biobank Cohort Study</atitle><jtitle>Annals of epidemiology</jtitle><addtitle>Ann Epidemiol</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>26</volume><issue>3</issue><spage>171</spage><epage>175</epage><pages>171-175</pages><issn>1047-2797</issn><eissn>1873-2585</eissn><abstract>Abstract Purpose The role of estrogen in cardiovascular health remains contested with discrepancies between findings from randomized controlled trials and observational studies. Mendelian randomization, which assesses the effect of lifelong endogenous exposure, may help elucidate these discrepancies. Methods We used separate sample instrumental variable analysis to estimate the association of log 17β-estradiol with factors related to cardiovascular disease risk (systolic and diastolic blood pressure, lipids, fasting glucose, body mass index, waist hip ratio, and waist circumference) and Framingham score, a predictor of 10-year risk of ischemic heart disease events, in older Chinese women from the Guangzhou Biobank Cohort Study (GBCS, n = 3092). The estimate was derived using the Wald estimator, that is, the ratio of the association of genetic determinants (rs1008805 and rs2175898) of log 17β-estradiol with cardiovascular disease risk factors and Framingham score in GBCS and the association of these genetic determinants with log 17β-estradiol in a sample of young women from Hong Kong ( n = 236). Results Genetically, higher 17β-estradiol was not associated with any cardiovascular disease-related risk factor or with Framingham score (−0.01, 95% confidence interval = −1.34 to 1.31). Conclusions Lifetime exposure to estrogen does not appear to be cardioprotective via the cardiovascular disease-related risk factors examined.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26907540</pmid><doi>10.1016/j.annepidem.2016.01.005</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-9933-5887</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of epidemiology, 2016-03, Vol.26 (3), p.171-175 |
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| subjects | Aged Aged, 80 and over Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - genetics Cardiovascular Diseases - metabolism Cardiovascular risk factors China - epidemiology Chinese Cohort Studies Estradiol - genetics Estradiol - metabolism Estrogen Female Genetic Markers Hong Kong - epidemiology Humans Internal Medicine Mendelian Randomization Analysis Middle Aged Polymorphism, Single Nucleotide Risk Factors Women Young Adult |
| title | Genetically predicted 17beta-estradiol and cardiovascular risk factors in women: a Mendelian randomization analysis using young women in Hong Kong and older women in the Guangzhou Biobank Cohort Study |
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