Atorvastatin enhances angiogenesis to reduce subdural hematoma in a rat model

Abstract Background and purpose Statins are active in reducing plasma lipids, suppressing inflammation and promoting angiogenesis. Because angiogenesis is critical for the absorbance of subdural hematoma (SDH), we hypothesize that atorvastatin promotes angiogenesis to enhance hematoma absorption. Me...

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Veröffentlicht in:	Journal of the neurological sciences 2016-03, Vol.362, p.91-99
Hauptverfasser:	Wang, Dong, Li, Tuo, Wei, Huijie, Wang, Yi, Yang, Guili, Tian, Ye, Zhao, Zilong, Wang, Liang, Yu, Shengping, Zhang, Yongqiang, Chen, Jieli, Jiang, Rongcai, Zhang, Jian Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen - blood Analysis of Variance Angiogenesis Angiopoietin-1 - genetics Angiopoietin-1 - metabolism Animals Anticholesteremic Agents - therapeutic use Antigens, CD34 - blood Atorvastatin Atorvastatin Calcium - pharmacology Atorvastatin Calcium - therapeutic use Disease Models, Animal Dose-Response Relationship, Drug Endothelial Progenitor Cells - drug effects Endothelial Progenitor Cells - ultrastructure Gene Expression Regulation - drug effects Hematoma, Subdural - diagnostic imaging Hematoma, Subdural - drug therapy Magnetic Resonance Imaging Male Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Microscopy, Electron, Transmission Neovascularization, Physiologic - drug effects Neurology Rat model Rats Rats, Wistar RNA, Messenger - metabolism Subdural hematoma Time Factors Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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