Abnormal default-mode network homogeneity and its correlations with personality in drug-naive somatization disorder at rest
Abstract Background While the default-mode network (DMN) appears to play a crucial role in patients suffering from somatization disorder (SD), the abnormalities of the network homogeneity (NH) of the DMN in SD patients have been poorly explored. The aim of this study is to examine DMN NH using an NH...
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| Veröffentlicht in: | Journal of affective disorders 2016-03, Vol.193, p.81-88 |
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| creator | Wei, Shubao Su, Qinji Jiang, Muliang Liu, Feng Yao, Dapeng Dai, Yi Long, Liling Song, Yan Yu, Miaoyu Zhang, Zhikun Zhao, Jingping Guo, Wenbin |
| description | Abstract Background While the default-mode network (DMN) appears to play a crucial role in patients suffering from somatization disorder (SD), the abnormalities of the network homogeneity (NH) of the DMN in SD patients have been poorly explored. The aim of this study is to examine DMN NH using an NH approach in patients suffering from SD at rest and determine its correlations with personality as measured by the Eysenck Personality Questionnaire (EPQ). Methods A total of 25 drug-naive patients with SD and 28 sex-, age-, and education-matched healthy controls underwent functional magnetic resonance imaging scans at rest. The data were analyzed by an automated NH method. Results Patients showed increased NH in the left superior frontal gyrus and decreased NH in the bilateral precuneus. Moreover, a significantly negative correlation was observed between the NH values in the bilateral precuneus and the EPQ-Neuroticism scores. Limitations The present study should be considered preliminary due to a lenient, uncorrected threshold of p |
| doi_str_mv | 10.1016/j.jad.2015.12.052 |
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The aim of this study is to examine DMN NH using an NH approach in patients suffering from SD at rest and determine its correlations with personality as measured by the Eysenck Personality Questionnaire (EPQ). Methods A total of 25 drug-naive patients with SD and 28 sex-, age-, and education-matched healthy controls underwent functional magnetic resonance imaging scans at rest. The data were analyzed by an automated NH method. Results Patients showed increased NH in the left superior frontal gyrus and decreased NH in the bilateral precuneus. Moreover, a significantly negative correlation was observed between the NH values in the bilateral precuneus and the EPQ-Neuroticism scores. Limitations The present study should be considered preliminary due to a lenient, uncorrected threshold of p <0.01. Conclusions The results suggest that abnormal DMN NH exists in drug-naive SD and further highlight the importance of the DMN in the pathophysiology of SD.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2015.12.052</identifier><identifier>PMID: 26771948</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Anxiety Disorders - physiopathology ; Case-Control Studies ; Eysenck Personality Questionnaire ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Network homogeneity ; Neural Pathways - physiopathology ; Neuroticism ; Parietal Lobe - physiopathology ; Personality - physiology ; Personality Inventory ; Precuneus ; Prefrontal Cortex - physiopathology ; Psychiatry ; Rest - physiology ; Somatization disorder ; Somatoform Disorders - physiopathology ; Superior frontal gyrus</subject><ispartof>Journal of affective disorders, 2016-03, Vol.193, p.81-88</ispartof><rights>Elsevier B.V.</rights><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-ae4727c9e42648b60b105bedf6ab32c4d68d7dc13666ee2abdc34a9b7a5ba0733</citedby><cites>FETCH-LOGICAL-c441t-ae4727c9e42648b60b105bedf6ab32c4d68d7dc13666ee2abdc34a9b7a5ba0733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jad.2015.12.052$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26771948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wei, Shubao</creatorcontrib><creatorcontrib>Su, Qinji</creatorcontrib><creatorcontrib>Jiang, Muliang</creatorcontrib><creatorcontrib>Liu, Feng</creatorcontrib><creatorcontrib>Yao, Dapeng</creatorcontrib><creatorcontrib>Dai, Yi</creatorcontrib><creatorcontrib>Long, Liling</creatorcontrib><creatorcontrib>Song, Yan</creatorcontrib><creatorcontrib>Yu, Miaoyu</creatorcontrib><creatorcontrib>Zhang, Zhikun</creatorcontrib><creatorcontrib>Zhao, Jingping</creatorcontrib><creatorcontrib>Guo, Wenbin</creatorcontrib><title>Abnormal default-mode network homogeneity and its correlations with personality in drug-naive somatization disorder at rest</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>Abstract Background While the default-mode network (DMN) appears to play a crucial role in patients suffering from somatization disorder (SD), the abnormalities of the network homogeneity (NH) of the DMN in SD patients have been poorly explored. The aim of this study is to examine DMN NH using an NH approach in patients suffering from SD at rest and determine its correlations with personality as measured by the Eysenck Personality Questionnaire (EPQ). Methods A total of 25 drug-naive patients with SD and 28 sex-, age-, and education-matched healthy controls underwent functional magnetic resonance imaging scans at rest. The data were analyzed by an automated NH method. Results Patients showed increased NH in the left superior frontal gyrus and decreased NH in the bilateral precuneus. Moreover, a significantly negative correlation was observed between the NH values in the bilateral precuneus and the EPQ-Neuroticism scores. Limitations The present study should be considered preliminary due to a lenient, uncorrected threshold of p <0.01. Conclusions The results suggest that abnormal DMN NH exists in drug-naive SD and further highlight the importance of the DMN in the pathophysiology of SD.</description><subject>Adult</subject><subject>Anxiety Disorders - physiopathology</subject><subject>Case-Control Studies</subject><subject>Eysenck Personality Questionnaire</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Network homogeneity</subject><subject>Neural Pathways - physiopathology</subject><subject>Neuroticism</subject><subject>Parietal Lobe - physiopathology</subject><subject>Personality - physiology</subject><subject>Personality Inventory</subject><subject>Precuneus</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychiatry</subject><subject>Rest - physiology</subject><subject>Somatization disorder</subject><subject>Somatoform Disorders - physiopathology</subject><subject>Superior frontal gyrus</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1u1DAUhS0EokPhAdggL9kk-CexJ0JCqqryI1ViAawtx77TOnXswXZaDbw8TqewYIFYefOdY937XYReUtJSQsWbqZ20bRmhfUtZS3r2CG1oL3nDeiofo01l-oZwJk_Qs5wnQogYJHmKTpiQkg7ddoN-no0hpll7bGGnF1-aOVrAAcpdTDf4Os7xCgK4csA6WOxKxiamBF4XF0PGd65c4z2kHIP2K-UCtmm5aoJ2t4BznCv44x7G1uWYLCSsC06Qy3P0ZKd9hhcP7yn69v7i6_nH5vLzh0_nZ5eN6TpaGg2dZNIM0DHRbUdBRkr6EexO6JEz01mxtdIayoUQAEyP1vBOD6PU_aiJ5PwUvT727lP8vtSP1eyyAe91gLhkReVAhroxTv4DFWwQpL9H6RE1KeacYKf2yc06HRQlatWjJlX1qFWPokxVPTXz6qF-GWewfxK_fVTg7RGAuo9bB0ll4yAYsC6BKcpG98_6d3-ljXfBGe1v4AB5ikuqluoUKteA-rLex3oetM4jCaX8FxMxt7c</recordid><startdate>20160315</startdate><enddate>20160315</enddate><creator>Wei, Shubao</creator><creator>Su, Qinji</creator><creator>Jiang, Muliang</creator><creator>Liu, Feng</creator><creator>Yao, Dapeng</creator><creator>Dai, Yi</creator><creator>Long, Liling</creator><creator>Song, Yan</creator><creator>Yu, Miaoyu</creator><creator>Zhang, Zhikun</creator><creator>Zhao, Jingping</creator><creator>Guo, Wenbin</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20160315</creationdate><title>Abnormal default-mode network homogeneity and its correlations with personality in drug-naive somatization disorder at rest</title><author>Wei, Shubao ; Su, Qinji ; Jiang, Muliang ; Liu, Feng ; Yao, Dapeng ; Dai, Yi ; Long, Liling ; Song, Yan ; Yu, Miaoyu ; Zhang, Zhikun ; Zhao, Jingping ; Guo, Wenbin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-ae4727c9e42648b60b105bedf6ab32c4d68d7dc13666ee2abdc34a9b7a5ba0733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Anxiety Disorders - physiopathology</topic><topic>Case-Control Studies</topic><topic>Eysenck Personality Questionnaire</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Network homogeneity</topic><topic>Neural Pathways - physiopathology</topic><topic>Neuroticism</topic><topic>Parietal Lobe - physiopathology</topic><topic>Personality - physiology</topic><topic>Personality Inventory</topic><topic>Precuneus</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Psychiatry</topic><topic>Rest - physiology</topic><topic>Somatization disorder</topic><topic>Somatoform Disorders - physiopathology</topic><topic>Superior frontal gyrus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, Shubao</creatorcontrib><creatorcontrib>Su, Qinji</creatorcontrib><creatorcontrib>Jiang, Muliang</creatorcontrib><creatorcontrib>Liu, Feng</creatorcontrib><creatorcontrib>Yao, Dapeng</creatorcontrib><creatorcontrib>Dai, Yi</creatorcontrib><creatorcontrib>Long, Liling</creatorcontrib><creatorcontrib>Song, Yan</creatorcontrib><creatorcontrib>Yu, Miaoyu</creatorcontrib><creatorcontrib>Zhang, Zhikun</creatorcontrib><creatorcontrib>Zhao, Jingping</creatorcontrib><creatorcontrib>Guo, Wenbin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, Shubao</au><au>Su, Qinji</au><au>Jiang, Muliang</au><au>Liu, Feng</au><au>Yao, Dapeng</au><au>Dai, Yi</au><au>Long, Liling</au><au>Song, Yan</au><au>Yu, Miaoyu</au><au>Zhang, Zhikun</au><au>Zhao, Jingping</au><au>Guo, Wenbin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal default-mode network homogeneity and its correlations with personality in drug-naive somatization disorder at rest</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2016-03-15</date><risdate>2016</risdate><volume>193</volume><spage>81</spage><epage>88</epage><pages>81-88</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><abstract>Abstract Background While the default-mode network (DMN) appears to play a crucial role in patients suffering from somatization disorder (SD), the abnormalities of the network homogeneity (NH) of the DMN in SD patients have been poorly explored. The aim of this study is to examine DMN NH using an NH approach in patients suffering from SD at rest and determine its correlations with personality as measured by the Eysenck Personality Questionnaire (EPQ). Methods A total of 25 drug-naive patients with SD and 28 sex-, age-, and education-matched healthy controls underwent functional magnetic resonance imaging scans at rest. The data were analyzed by an automated NH method. Results Patients showed increased NH in the left superior frontal gyrus and decreased NH in the bilateral precuneus. Moreover, a significantly negative correlation was observed between the NH values in the bilateral precuneus and the EPQ-Neuroticism scores. Limitations The present study should be considered preliminary due to a lenient, uncorrected threshold of p <0.01. Conclusions The results suggest that abnormal DMN NH exists in drug-naive SD and further highlight the importance of the DMN in the pathophysiology of SD.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26771948</pmid><doi>10.1016/j.jad.2015.12.052</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Anxiety Disorders - physiopathology Case-Control Studies Eysenck Personality Questionnaire Female Humans Magnetic Resonance Imaging Male Middle Aged Network homogeneity Neural Pathways - physiopathology Neuroticism Parietal Lobe - physiopathology Personality - physiology Personality Inventory Precuneus Prefrontal Cortex - physiopathology Psychiatry Rest - physiology Somatization disorder Somatoform Disorders - physiopathology Superior frontal gyrus |
| title | Abnormal default-mode network homogeneity and its correlations with personality in drug-naive somatization disorder at rest |
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