Subunit interactions of the disease-related hexameric GlcNAc-1-phosphotransferase complex

The multimeric GlcNAc-1-phosphotransferase complex catalyzes the formation of mannose 6-phosphate recognition marker on lysosomal enzymes required for receptor-mediated targeting to lysosomes. GNPTAB and GNPTG encode the α/β-subunit precursor membrane proteins and the soluble γ-subunits, respectivel...

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Veröffentlicht in:	Human molecular genetics 2015-12, Vol.24 (23), p.6826-6835
Hauptverfasser:	De Pace, Raffaella, Velho, Renata Voltolini, Encarnação, Marisa, Marschner, Katrin, Braulke, Thomas, Pohl, Sandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Binding Sites Cell Line Glycosylation Humans Lysosomes - enzymology Mutation Protein Multimerization Protein Structure, Quaternary Transferases (Other Substituted Phosphate Groups) - genetics Transferases (Other Substituted Phosphate Groups) - metabolism
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