Amyloid β-interacting partners in Alzheimer's disease: From accomplices to possible therapeutic targets

Alzheimer's disease (AD) is one of the most devastating neurodegenerative diseases in modern society because of insurmountable difficulties in early diagnosis and lack of therapeutic treatments. AD pathogenesis is tightly linked to the abnormal accumulation and aggregation of amyloid β (Aβ), se...

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Veröffentlicht in:	Progress in neurobiology 2016-02, Vol.137, p.17-38
Hauptverfasser:	Han, Sun-Ho, Park, Jong-Chan, Mook-Jung, Inhee
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - therapy Amyloid beta-Peptides - metabolism Animals Apolipoprotein E4 - metabolism Apolipoprotein E4 - therapeutic use Blood Proteins - metabolism Blood Proteins - therapeutic use Brain - drug effects Brain - metabolism Brain - pathology Humans LDL-Receptor Related Proteins - metabolism Metals - metabolism Metals - therapeutic use Prions - metabolism Receptors, Cell Surface - metabolism
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