Gray matter atrophy associated with mild cognitive impairment in Parkinson’s disease
•There exists extensive gray matter loss in patients with Parkinson’s disease (PD).•Early cognitive deficits in PD is related to gray matter atrophy.•Imaging biomarker for PD with mild cognitive impairment is proposed. The underlying pathology of brain leading to cognitive impairment in Parkinson’s...
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| Veröffentlicht in: | Neuroscience letters 2016-03, Vol.617, p.160-165 |
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| creator | Chen, Fu-Xiang Kang, De-Zhi Chen, Fu-Yong Liu, Ying Wu, Gang Li, Xun Yu, Liang-Hong Lin, Yuan-Xiang Lin, Zhang-Ya |
| description | •There exists extensive gray matter loss in patients with Parkinson’s disease (PD).•Early cognitive deficits in PD is related to gray matter atrophy.•Imaging biomarker for PD with mild cognitive impairment is proposed.
The underlying pathology of brain leading to cognitive impairment in Parkinson’s disease (PD) remains poorly understood. The aim of our study was to test the hypothesis that mild cognitive impairment (MCI) in PD may be related to atrophy of special gray matter regions.
High-resolution T1-weighted magnetic resonance images of the brains and comprehensive cognitive function tests were acquired in 37 PD patients and 21 healthy controls (HC) from September 2013 to October 2014. Patients were divided into two groups: PD with MCI (PD-MCI, n=18) and PD with normal cognition (PDNC, n=19). Gray matter density differences were analyzed using voxel-based morphometry (VBM). VBM and cognitive results, UPDRS scores and Hoehn–Yahr stages were compared between PD-MCI, PDCN and HC group, and correlation analyses were performed between those brain areas and cognition scores, UPDRS scores and disease duration, which showed significant group differences.
The demographic data and motor severity among three groups were similar. However, comprehensive cognitive function results were more severe in PD-MCI than the other two groups. Compared to the HC group, the PDNC group showed reductions in gray matter density in frontal, temporal, parietal, bilateral insula lobes and many other regions of brain. Besides above changes, the PD-MCI group also revealed gray matter concentration decrease in left hippocampus and thalamus, and these changes still remained when compared with the PDNC group. The HC group did not show any more areas of atrophy in gray matter than others. Gray matter loss in PD represented significant correlations with global cognitive scores, motor severity or disease duration in some of these atrophic regions.
The initial stages of cognitive function decline in patients with PD is closely associated with gray matter atrophy in left hippocampus and thalamus. These two regions may serve as potential imaging biomarkers for PD-MCI. |
| doi_str_mv | 10.1016/j.neulet.2015.12.055 |
| format | Article |
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The underlying pathology of brain leading to cognitive impairment in Parkinson’s disease (PD) remains poorly understood. The aim of our study was to test the hypothesis that mild cognitive impairment (MCI) in PD may be related to atrophy of special gray matter regions.
High-resolution T1-weighted magnetic resonance images of the brains and comprehensive cognitive function tests were acquired in 37 PD patients and 21 healthy controls (HC) from September 2013 to October 2014. Patients were divided into two groups: PD with MCI (PD-MCI, n=18) and PD with normal cognition (PDNC, n=19). Gray matter density differences were analyzed using voxel-based morphometry (VBM). VBM and cognitive results, UPDRS scores and Hoehn–Yahr stages were compared between PD-MCI, PDCN and HC group, and correlation analyses were performed between those brain areas and cognition scores, UPDRS scores and disease duration, which showed significant group differences.
The demographic data and motor severity among three groups were similar. However, comprehensive cognitive function results were more severe in PD-MCI than the other two groups. Compared to the HC group, the PDNC group showed reductions in gray matter density in frontal, temporal, parietal, bilateral insula lobes and many other regions of brain. Besides above changes, the PD-MCI group also revealed gray matter concentration decrease in left hippocampus and thalamus, and these changes still remained when compared with the PDNC group. The HC group did not show any more areas of atrophy in gray matter than others. Gray matter loss in PD represented significant correlations with global cognitive scores, motor severity or disease duration in some of these atrophic regions.
The initial stages of cognitive function decline in patients with PD is closely associated with gray matter atrophy in left hippocampus and thalamus. These two regions may serve as potential imaging biomarkers for PD-MCI.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2015.12.055</identifier><identifier>PMID: 26742642</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Aged ; Atrophy - pathology ; Brain - pathology ; Brain atrophy ; Case-Control Studies ; Cognitive Dysfunction - pathology ; Female ; Gray Matter - pathology ; Humans ; Male ; Middle Aged ; Mild cognitive impairment ; Parkinson Disease - pathology ; Parkinson Disease - psychology ; Parkinson’s disease ; Voxel-based morphometry</subject><ispartof>Neuroscience letters, 2016-03, Vol.617, p.160-165</ispartof><rights>2016</rights><rights>Copyright © 2016. Published by Elsevier Ireland Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-b204df0ec3b6ed618fe4929ac2268617dab7f613896044af3deeb7eed34fd7a13</citedby><cites>FETCH-LOGICAL-c395t-b204df0ec3b6ed618fe4929ac2268617dab7f613896044af3deeb7eed34fd7a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2015.12.055$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26742642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Fu-Xiang</creatorcontrib><creatorcontrib>Kang, De-Zhi</creatorcontrib><creatorcontrib>Chen, Fu-Yong</creatorcontrib><creatorcontrib>Liu, Ying</creatorcontrib><creatorcontrib>Wu, Gang</creatorcontrib><creatorcontrib>Li, Xun</creatorcontrib><creatorcontrib>Yu, Liang-Hong</creatorcontrib><creatorcontrib>Lin, Yuan-Xiang</creatorcontrib><creatorcontrib>Lin, Zhang-Ya</creatorcontrib><title>Gray matter atrophy associated with mild cognitive impairment in Parkinson’s disease</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>•There exists extensive gray matter loss in patients with Parkinson’s disease (PD).•Early cognitive deficits in PD is related to gray matter atrophy.•Imaging biomarker for PD with mild cognitive impairment is proposed.
The underlying pathology of brain leading to cognitive impairment in Parkinson’s disease (PD) remains poorly understood. The aim of our study was to test the hypothesis that mild cognitive impairment (MCI) in PD may be related to atrophy of special gray matter regions.
High-resolution T1-weighted magnetic resonance images of the brains and comprehensive cognitive function tests were acquired in 37 PD patients and 21 healthy controls (HC) from September 2013 to October 2014. Patients were divided into two groups: PD with MCI (PD-MCI, n=18) and PD with normal cognition (PDNC, n=19). Gray matter density differences were analyzed using voxel-based morphometry (VBM). VBM and cognitive results, UPDRS scores and Hoehn–Yahr stages were compared between PD-MCI, PDCN and HC group, and correlation analyses were performed between those brain areas and cognition scores, UPDRS scores and disease duration, which showed significant group differences.
The demographic data and motor severity among three groups were similar. However, comprehensive cognitive function results were more severe in PD-MCI than the other two groups. Compared to the HC group, the PDNC group showed reductions in gray matter density in frontal, temporal, parietal, bilateral insula lobes and many other regions of brain. Besides above changes, the PD-MCI group also revealed gray matter concentration decrease in left hippocampus and thalamus, and these changes still remained when compared with the PDNC group. The HC group did not show any more areas of atrophy in gray matter than others. Gray matter loss in PD represented significant correlations with global cognitive scores, motor severity or disease duration in some of these atrophic regions.
The initial stages of cognitive function decline in patients with PD is closely associated with gray matter atrophy in left hippocampus and thalamus. These two regions may serve as potential imaging biomarkers for PD-MCI.</description><subject>Aged</subject><subject>Atrophy - pathology</subject><subject>Brain - pathology</subject><subject>Brain atrophy</subject><subject>Case-Control Studies</subject><subject>Cognitive Dysfunction - pathology</subject><subject>Female</subject><subject>Gray Matter - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mild cognitive impairment</subject><subject>Parkinson Disease - pathology</subject><subject>Parkinson Disease - psychology</subject><subject>Parkinson’s disease</subject><subject>Voxel-based morphometry</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkL1OHDEUhS0Egg3wBihySTOT65-x1w1ShBISCSkpgNby2HfAy_xsbC_RdnmNvB5PkkFLKKNUp_nOOdJHyBmDmgFTH1b1iJseS82BNTXjNTTNHlmwpeaVNprvkwUIkJUwEo7Iu5xXANCwRh6SI6605EryBbm7Sm5LB1cKJupKmtYPW-pynnx0BQP9GcsDHWIfqJ_ux1jiE9I4rF1MA46FxpF-d-kxjnkan3_9zjTEjC7jCTnoXJ_x9DWPye3nTzeXX6rrb1dfLz9eV16YplQtBxk6QC9ahUGxZYfScOM852qpmA6u1Z1iYmkUSOk6ERBbjRiE7IJ2TByT893uOk0_NpiLHWL22PduxGmTLdMGjGw0wH-gWjbcCM5nVO5Qn6acE3Z2neLg0tYysC_y7cru5NsX-ZZxO8ufa-9fHzbtgOGt9Nf2DFzsAJyVPEVMNvuIo8cQE_piwxT__fAHgzKZrw</recordid><startdate>20160323</startdate><enddate>20160323</enddate><creator>Chen, Fu-Xiang</creator><creator>Kang, De-Zhi</creator><creator>Chen, Fu-Yong</creator><creator>Liu, Ying</creator><creator>Wu, Gang</creator><creator>Li, Xun</creator><creator>Yu, Liang-Hong</creator><creator>Lin, Yuan-Xiang</creator><creator>Lin, Zhang-Ya</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20160323</creationdate><title>Gray matter atrophy associated with mild cognitive impairment in Parkinson’s disease</title><author>Chen, Fu-Xiang ; Kang, De-Zhi ; Chen, Fu-Yong ; Liu, Ying ; Wu, Gang ; Li, Xun ; Yu, Liang-Hong ; Lin, Yuan-Xiang ; Lin, Zhang-Ya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-b204df0ec3b6ed618fe4929ac2268617dab7f613896044af3deeb7eed34fd7a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Atrophy - pathology</topic><topic>Brain - pathology</topic><topic>Brain atrophy</topic><topic>Case-Control Studies</topic><topic>Cognitive Dysfunction - pathology</topic><topic>Female</topic><topic>Gray Matter - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mild cognitive impairment</topic><topic>Parkinson Disease - pathology</topic><topic>Parkinson Disease - psychology</topic><topic>Parkinson’s disease</topic><topic>Voxel-based morphometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Fu-Xiang</creatorcontrib><creatorcontrib>Kang, De-Zhi</creatorcontrib><creatorcontrib>Chen, Fu-Yong</creatorcontrib><creatorcontrib>Liu, Ying</creatorcontrib><creatorcontrib>Wu, Gang</creatorcontrib><creatorcontrib>Li, Xun</creatorcontrib><creatorcontrib>Yu, Liang-Hong</creatorcontrib><creatorcontrib>Lin, Yuan-Xiang</creatorcontrib><creatorcontrib>Lin, Zhang-Ya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Fu-Xiang</au><au>Kang, De-Zhi</au><au>Chen, Fu-Yong</au><au>Liu, Ying</au><au>Wu, Gang</au><au>Li, Xun</au><au>Yu, Liang-Hong</au><au>Lin, Yuan-Xiang</au><au>Lin, Zhang-Ya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gray matter atrophy associated with mild cognitive impairment in Parkinson’s disease</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2016-03-23</date><risdate>2016</risdate><volume>617</volume><spage>160</spage><epage>165</epage><pages>160-165</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract>•There exists extensive gray matter loss in patients with Parkinson’s disease (PD).•Early cognitive deficits in PD is related to gray matter atrophy.•Imaging biomarker for PD with mild cognitive impairment is proposed.
The underlying pathology of brain leading to cognitive impairment in Parkinson’s disease (PD) remains poorly understood. The aim of our study was to test the hypothesis that mild cognitive impairment (MCI) in PD may be related to atrophy of special gray matter regions.
High-resolution T1-weighted magnetic resonance images of the brains and comprehensive cognitive function tests were acquired in 37 PD patients and 21 healthy controls (HC) from September 2013 to October 2014. Patients were divided into two groups: PD with MCI (PD-MCI, n=18) and PD with normal cognition (PDNC, n=19). Gray matter density differences were analyzed using voxel-based morphometry (VBM). VBM and cognitive results, UPDRS scores and Hoehn–Yahr stages were compared between PD-MCI, PDCN and HC group, and correlation analyses were performed between those brain areas and cognition scores, UPDRS scores and disease duration, which showed significant group differences.
The demographic data and motor severity among three groups were similar. However, comprehensive cognitive function results were more severe in PD-MCI than the other two groups. Compared to the HC group, the PDNC group showed reductions in gray matter density in frontal, temporal, parietal, bilateral insula lobes and many other regions of brain. Besides above changes, the PD-MCI group also revealed gray matter concentration decrease in left hippocampus and thalamus, and these changes still remained when compared with the PDNC group. The HC group did not show any more areas of atrophy in gray matter than others. Gray matter loss in PD represented significant correlations with global cognitive scores, motor severity or disease duration in some of these atrophic regions.
The initial stages of cognitive function decline in patients with PD is closely associated with gray matter atrophy in left hippocampus and thalamus. These two regions may serve as potential imaging biomarkers for PD-MCI.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>26742642</pmid><doi>10.1016/j.neulet.2015.12.055</doi><tpages>6</tpages></addata></record> |
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| ispartof | Neuroscience letters, 2016-03, Vol.617, p.160-165 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aged Atrophy - pathology Brain - pathology Brain atrophy Case-Control Studies Cognitive Dysfunction - pathology Female Gray Matter - pathology Humans Male Middle Aged Mild cognitive impairment Parkinson Disease - pathology Parkinson Disease - psychology Parkinson’s disease Voxel-based morphometry |
| title | Gray matter atrophy associated with mild cognitive impairment in Parkinson’s disease |
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