Synthesis, and docking studies of phenylpyrimidine-carboxamide derivatives bearing 1H-pyrrolo[2,3-b]pyridine moiety as c-Met inhibitors

[Display omitted] Four series of phenylpyrimidine-carboxamide derivatives bearing 1H-pyrrolo[2,3-b]pyridine moiety (14a–e, 15a–g, 16a–e and 17a–g) were designed, synthesized and evaluated for the IC50 values against three cancer cell lines (A549, PC-3 and MCF-7). Four selected compounds (15e, 16a–b...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2016-04, Vol.24 (8), p.1749-1756
Hauptverfasser:	Zhu, Wufu, Wang, Wenhui, Xu, Shan, Wang, Jianqiang, Tang, Qidong, Wu, Chunjiang, Zhao, Yanfang, Zheng, Pengwu
Format:	Artikel
Sprache:	eng
Schlagworte:	1H-Pyrrolo[2,3-b]pyridine Amides - chemistry Amides - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity c-Met inhibitors Cell Line, Tumor Cell Proliferation - drug effects Docking Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans Molecular Docking Simulation Molecular Structure Phenylpyrimidine Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-met - antagonists & inhibitors Proto-Oncogene Proteins c-met - metabolism Pyridines - chemistry Pyridines - pharmacology Pyrimidines - chemistry Pyrimidines - pharmacology Pyrroles - chemistry Pyrroles - pharmacology Structure-Activity Relationship Synthesis
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