Acridin-3,6-dialkyldithiourea hydrochlorides as new photosensitizers for photodynamic therapy of mouse leukemia cells

[Display omitted] •Photocytotoxicity of new proflavines useful in the anticancer therapy was examined.•Irradiation at 365nm increased cytotoxicity of new proflavines about ten times.•Intracellular distribution of the new photosensitizers (PS) was investigated.•Sequestration of these compounds in lys...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2016-05, Vol.24 (9), p.2011-2022
Hauptverfasser:	Cisáriková, A., Barbieriková, Z., Janovec, L., Imrich, J., Hunáková, L., Bačová, Z., Paulíková, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines Acridines - chemistry Acridines - therapeutic use Animals Anticancer drugs Cell Line, Tumor Electron Spin Resonance Spectroscopy Leukemia, Experimental - drug therapy Mice Photochemotherapy Photodynamic therapy Photosensitizers Photosensitizing Agents - pharmacology
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