Design, synthesis, topoisomerase I & II inhibitory activity, antiproliferative activity, and structure–activity relationship study of pyrazoline derivatives: An ATP-competitive human topoisomerase IIα catalytic inhibitor

[Display omitted] •Synthesis a series of pyrazoline derivatives.•ATP-competitive human topoisomerase IIα catalytic inhibitor.•Inhibited endogenous topo-mediated pBR322 plasmid relaxation more efficiently than Etoposide. A series of pyrazoline derivatives (5) were synthesized in 92–96% yields from ch...

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