Synthesis, isomerization and biological activity of novel 2-selenohydantoin derivatives

[Display omitted] A set of novel selenohydantoins were synthesized via a convenient and versatile approach involving the reaction of isoselenocyanates with various amines. We also revealed an unexpected Z→E isomerization of pyridin-2-yl-substituted selenohydantoins in the presence of Cu2+ cations. T...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2016-02, Vol.24 (4), p.802-811
Hauptverfasser:	Ivanenkov, Yan A., Veselov, Mark S., Rezekin, Igor G., Skvortsov, Dmitriy A., Sandulenko, Yuri B., Polyakova, Marina V., Bezrukov, Dmitry S., Vasilevsky, Sergey V., Kukushkin, Maxim E., Moiseeva, Anna A., Finko, Alexander V., Koteliansky, Victor E., Klyachko, Natalia L., Filatova, Lubov A., Beloglazkina, Elena K., Zyk, Nikolay V., Majouga, Alexander G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer activity Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antioxidant activity Antioxidants - chemical synthesis Antioxidants - pharmacology Azoles - pharmacology Cell Line, Tumor Cell Survival - drug effects Complexation Copper - chemistry Cyanates - chemistry Drug Screening Assays, Antitumor Electrochemistry Glutathione Peroxidase - antagonists & inhibitors Glutathione Peroxidase - chemistry Humans Hydantoins - chemical synthesis Hydantoins - pharmacology Inhibitory Concentration 50 Isomerization Organoselenium Compounds - chemical synthesis Organoselenium Compounds - pharmacology Pyridines - chemistry Quantum Theory Quantum-chemical study Selenohydantoin Stereoisomerism Structure-Activity Relationship
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