An experimental platform using human intestinal epithelial cell lines to differentiate between hazardous and non-hazardous proteins

Human intestinal epithelial cell lines (T84, Caco-2, and HCT-8) grown on permeable Transwell™ filters serve as models of the gastrointestinal barrier. In this study, this in vitro model system was evaluated for effectiveness at distinguishing between hazardous and non-hazardous proteins. Indicators...

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Veröffentlicht in:	Food and chemical toxicology 2016-06, Vol.92, p.75-87
Hauptverfasser:	Hurley, Bryan P., Pirzai, Waheed, Eaton, Alex D., Harper, Marc, Roper, Jason, Zimmermann, Cindi, Ladics, Gregory S., Layton, Raymond J., Delaney, Bryan
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens - pharmacology Animals Arachis hypogaea Bacterial Toxins - pharmacology Cattle Cell Proliferation - drug effects Cells, Cultured Clostridium difficile Cytokines - metabolism Cytotoxicity Dietary Proteins - pharmacology Escherichia coli Humans Hymenoptera Intestinal epithelial cells Intestines - drug effects Intestines - pathology Lectins - pharmacology Listeria monocytogenes Neoplasms, Glandular and Epithelial - pathology Protein toxins Spinacia oleracea Streptococcus pyogenes Venoms - pharmacology
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