Neural correlates of improved executive function following erythropoietin treatment in mood disorders
Cognitive dysfunction in depression and bipolar disorder (BD) is insufficiently targeted by available treatments. Erythropoietin (EPO) increases neuroplasticity and may improve cognition in mood disorders, but the neuronal mechanisms of these effects are unknown. This functional magnetic resonance i...
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| Veröffentlicht in: | Psychological medicine 2016-06, Vol.46 (8), p.1679-1691 |
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| creator | Miskowiak, K. W. Vinberg, M. Glerup, L. Paulson, O. B. Knudsen, G. M. Ehrenreich, H. Harmer, C. J. Kessing, L. V. Siebner, H. R. Macoveanu, J. |
| description | Cognitive dysfunction in depression and bipolar disorder (BD) is insufficiently targeted by available treatments. Erythropoietin (EPO) increases neuroplasticity and may improve cognition in mood disorders, but the neuronal mechanisms of these effects are unknown. This functional magnetic resonance imaging (fMRI) study investigated the effects of EPO on neural circuitry activity during working memory (WM) performance.
Patients with treatment-resistant major depression, who were moderately depressed, or with BD in partial remission, were randomized to eight weekly infusions of EPO (40 000 IU) (N = 30) or saline (N = 26) in a double-blind, parallel-group design. Patients underwent fMRI, mood ratings and blood tests at baseline and week 14. During fMRI patients performed an n-back WM task.
EPO improved WM accuracy compared with saline (p = 0.045). Whole-brain analyses revealed that EPO increased WM load-related activity in the right superior frontal gyrus (SFG) compared with saline (p = 0.01). There was also enhanced WM load-related deactivation of the left hippocampus in EPO-treated compared to saline-treated patients (p = 0.03). Across the entire sample, baseline to follow-up changes in WM performance correlated positively with changes in WM-related SFG activity and negatively with hippocampal response (r = 0.28-0.30, p < 0.05). The effects of EPO were not associated with changes in mood or red blood cells (p ⩾0.08).
The present findings associate changes in WM-load related activity in the right SFG and left hippocampus with improved executive function in EPO-treated patients.
clinicaltrials.gov: NCT00916552. |
| doi_str_mv | 10.1017/S0033291716000209 |
| format | Article |
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Patients with treatment-resistant major depression, who were moderately depressed, or with BD in partial remission, were randomized to eight weekly infusions of EPO (40 000 IU) (N = 30) or saline (N = 26) in a double-blind, parallel-group design. Patients underwent fMRI, mood ratings and blood tests at baseline and week 14. During fMRI patients performed an n-back WM task.
EPO improved WM accuracy compared with saline (p = 0.045). Whole-brain analyses revealed that EPO increased WM load-related activity in the right superior frontal gyrus (SFG) compared with saline (p = 0.01). There was also enhanced WM load-related deactivation of the left hippocampus in EPO-treated compared to saline-treated patients (p = 0.03). Across the entire sample, baseline to follow-up changes in WM performance correlated positively with changes in WM-related SFG activity and negatively with hippocampal response (r = 0.28-0.30, p < 0.05). The effects of EPO were not associated with changes in mood or red blood cells (p ⩾0.08).
The present findings associate changes in WM-load related activity in the right SFG and left hippocampus with improved executive function in EPO-treated patients.
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Patients with treatment-resistant major depression, who were moderately depressed, or with BD in partial remission, were randomized to eight weekly infusions of EPO (40 000 IU) (N = 30) or saline (N = 26) in a double-blind, parallel-group design. Patients underwent fMRI, mood ratings and blood tests at baseline and week 14. During fMRI patients performed an n-back WM task.
EPO improved WM accuracy compared with saline (p = 0.045). Whole-brain analyses revealed that EPO increased WM load-related activity in the right superior frontal gyrus (SFG) compared with saline (p = 0.01). There was also enhanced WM load-related deactivation of the left hippocampus in EPO-treated compared to saline-treated patients (p = 0.03). Across the entire sample, baseline to follow-up changes in WM performance correlated positively with changes in WM-related SFG activity and negatively with hippocampal response (r = 0.28-0.30, p < 0.05). The effects of EPO were not associated with changes in mood or red blood cells (p ⩾0.08).
The present findings associate changes in WM-load related activity in the right SFG and left hippocampus with improved executive function in EPO-treated patients.
clinicaltrials.gov: NCT00916552.</description><subject>Adult</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - diagnostic imaging</subject><subject>Bipolar Disorder - drug therapy</subject><subject>Bipolar Disorder - physiopathology</subject><subject>Bipolar Disorder - psychology</subject><subject>Blood cells</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - physiopathology</subject><subject>Brain mapping</subject><subject>Clinical research</subject><subject>Clinical trials</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - diagnostic imaging</subject><subject>Cognitive Dysfunction - drug therapy</subject><subject>Cognitive Dysfunction - physiopathology</subject><subject>Cognitive Dysfunction - psychology</subject><subject>Deactivation</subject><subject>Depression</subject><subject>Depressive Disorder, Major - diagnostic imaging</subject><subject>Depressive Disorder, Major - drug therapy</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Depressive Disorder, Major - psychology</subject><subject>Depressive Disorder, Treatment-Resistant - diagnostic imaging</subject><subject>Depressive Disorder, Treatment-Resistant - drug therapy</subject><subject>Depressive Disorder, Treatment-Resistant - physiopathology</subject><subject>Depressive Disorder, Treatment-Resistant - psychology</subject><subject>Double-Blind Method</subject><subject>Dysfunction</subject><subject>Emotional disorders</subject><subject>Erythrocytes</subject><subject>Erythropoietin</subject><subject>Erythropoietin - therapeutic use</subject><subject>Executive Function</subject><subject>Female</subject><subject>Frontal gyrus</subject><subject>Functional magnetic resonance imaging</subject><subject>Functional Neuroimaging</subject><subject>Functional plasticity</subject><subject>Hippocampal plasticity</subject><subject>Hippocampus</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Memory, Short-Term</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Mood</subject><subject>Neural networks</subject><subject>Neural plasticity</subject><subject>Neuroimaging</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Original Articles</subject><subject>Patients</subject><subject>Remission</subject><subject>Remission (Medicine)</subject><subject>Short term memory</subject><subject>Spatial Memory</subject><subject>Treatment Outcome</subject><issn>0033-2917</issn><issn>1469-8978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkUFPHSEUhUljU19tf4AbQ-Kmm7FcGGFYGqNtE2MXbdcTHlwUMzM8gbH678vE18ZoTLoicL577r0cQvaBHQED9fkHY0JwDQokY4wz_YasoJW66bTqdshqkZtF3yXvc75hDAS0_B3Z5VJrCVquCF7inMxAbUwJB1Mw0-hpGDcp3qGjeI92LuEOqZ8nW0KcqI_DEH-H6YpieijXKW5iwBImWhKaMuJUaL2MMTrqQo7JYcofyFtvhowft-ce-XV-9vP0a3Px_cu305OLxratLo2yxjnrwSrU0Ik1KjSdr0sAKs0dd8YIfsy0EuDqk5GsInytpPMo0R-LPfLp0beOfztjLv0YssVhMBPGOfegNNOilar9D7RTrH4SX9DDZ-hNnNNUF1ko2UouuKoUPFI2xZwT-n6TwmjSQw-sX-LqX8RVaw62zvN6RPev4m8-FRBbUzOuU3BX-KT3q7Z_AOZXoMM</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Miskowiak, K. 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W. ; Vinberg, M. ; Glerup, L. ; Paulson, O. B. ; Knudsen, G. M. ; Ehrenreich, H. ; Harmer, C. J. ; Kessing, L. V. ; Siebner, H. 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W.</au><au>Vinberg, M.</au><au>Glerup, L.</au><au>Paulson, O. B.</au><au>Knudsen, G. M.</au><au>Ehrenreich, H.</au><au>Harmer, C. J.</au><au>Kessing, L. V.</au><au>Siebner, H. R.</au><au>Macoveanu, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neural correlates of improved executive function following erythropoietin treatment in mood disorders</atitle><jtitle>Psychological medicine</jtitle><addtitle>Psychol. Med</addtitle><date>2016-06</date><risdate>2016</risdate><volume>46</volume><issue>8</issue><spage>1679</spage><epage>1691</epage><pages>1679-1691</pages><issn>0033-2917</issn><eissn>1469-8978</eissn><coden>PSMDCO</coden><abstract>Cognitive dysfunction in depression and bipolar disorder (BD) is insufficiently targeted by available treatments. Erythropoietin (EPO) increases neuroplasticity and may improve cognition in mood disorders, but the neuronal mechanisms of these effects are unknown. This functional magnetic resonance imaging (fMRI) study investigated the effects of EPO on neural circuitry activity during working memory (WM) performance.
Patients with treatment-resistant major depression, who were moderately depressed, or with BD in partial remission, were randomized to eight weekly infusions of EPO (40 000 IU) (N = 30) or saline (N = 26) in a double-blind, parallel-group design. Patients underwent fMRI, mood ratings and blood tests at baseline and week 14. During fMRI patients performed an n-back WM task.
EPO improved WM accuracy compared with saline (p = 0.045). Whole-brain analyses revealed that EPO increased WM load-related activity in the right superior frontal gyrus (SFG) compared with saline (p = 0.01). There was also enhanced WM load-related deactivation of the left hippocampus in EPO-treated compared to saline-treated patients (p = 0.03). Across the entire sample, baseline to follow-up changes in WM performance correlated positively with changes in WM-related SFG activity and negatively with hippocampal response (r = 0.28-0.30, p < 0.05). The effects of EPO were not associated with changes in mood or red blood cells (p ⩾0.08).
The present findings associate changes in WM-load related activity in the right SFG and left hippocampus with improved executive function in EPO-treated patients.
clinicaltrials.gov: NCT00916552.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>26996196</pmid><doi>10.1017/S0033291716000209</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Bipolar disorder Bipolar Disorder - diagnostic imaging Bipolar Disorder - drug therapy Bipolar Disorder - physiopathology Bipolar Disorder - psychology Blood cells Brain - diagnostic imaging Brain - physiopathology Brain mapping Clinical research Clinical trials Cognition Cognitive ability Cognitive Dysfunction - diagnostic imaging Cognitive Dysfunction - drug therapy Cognitive Dysfunction - physiopathology Cognitive Dysfunction - psychology Deactivation Depression Depressive Disorder, Major - diagnostic imaging Depressive Disorder, Major - drug therapy Depressive Disorder, Major - physiopathology Depressive Disorder, Major - psychology Depressive Disorder, Treatment-Resistant - diagnostic imaging Depressive Disorder, Treatment-Resistant - drug therapy Depressive Disorder, Treatment-Resistant - physiopathology Depressive Disorder, Treatment-Resistant - psychology Double-Blind Method Dysfunction Emotional disorders Erythrocytes Erythropoietin Erythropoietin - therapeutic use Executive Function Female Frontal gyrus Functional magnetic resonance imaging Functional Neuroimaging Functional plasticity Hippocampal plasticity Hippocampus Humans Magnetic Resonance Imaging Male Memory, Short-Term Mental depression Middle Aged Mood Neural networks Neural plasticity Neuroimaging NMR Nuclear magnetic resonance Original Articles Patients Remission Remission (Medicine) Short term memory Spatial Memory Treatment Outcome |
| title | Neural correlates of improved executive function following erythropoietin treatment in mood disorders |
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