Biomarker evaluation of skeletal muscle toxicity following clofibrate administration in rats

The use of sensitive biomarkers to monitor skeletal muscle toxicity in preclinical toxicity studies is important for the risk assessment in humans during the development of a novel compound. Skeletal muscle toxicity in Sprague Dawley Rats was induced with clofibrate at different dose levels for 7 da...

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Veröffentlicht in:	Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2016-05, Vol.68 (5), p.289-299
Hauptverfasser:	Bodié, Karen, Buck, Wayne R., Pieh, Julia, Liguori, Michael J., Popp, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Alanine Transaminase - urine Animals Aspartate Aminotransferases - blood Aspartate Aminotransferases - urine Biomarkers - blood Biomarkers - urine Clofibrate Clofibrate - toxicity Creatine Kinase - blood Creatine Kinase - urine Fatty Acid Binding Protein 3 Fatty Acid-Binding Proteins - blood Fatty Acid-Binding Proteins - urine Gene expression Gene Expression Profiling Heart - drug effects Hypolipidemic Agents - toxicity Male Muscle, Skeletal - drug effects Muscle, Skeletal - pathology Myocardium - pathology Myoglobin - blood Myosin Light Chains - blood Myosin Light Chains - urine Parvalbumins - blood Parvalbumins - urine Rat Rats Rats, Sprague-Dawley Skeletal muscle biomarker Troponin C - blood Troponin C - urine Troponin I - blood Troponin I - urine
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