7,8-dihydroxyflavone protects 6-OHDA and MPTP induced dopaminergic neurons degeneration through activation of TrkB in rodents

•7,8-DHF alleviated akinesia of 6-OHDA rat model of parkinsonism by protecting dopaminergic neurons.•7,8-DHF elevated TrkB phosphorylation in the SN in 6-OHDA rat model.•7,8-DHF protected acute MPTP neurotoxicity in mice. Brain-derived neurotrophic factor (BDNF) is a notably important neurotrophin w...

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Veröffentlicht in:	Neuroscience letters 2016-05, Vol.620, p.43-49
Hauptverfasser:	Luo, Dandan, Shi, Ying, Wang, Jun, Lin, Qing, Sun, Yi, Ye, Keqiang, Yan, Qiao, Zhang, Hai
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6-hydroxydopamine 7,8-dihydroxyflavone Animals Behavior, Animal - drug effects Brain derived neurotrophic factor Dopaminergic Neurons - drug effects Dopaminergic Neurons - pathology Flavones - pharmacology Flavones - therapeutic use Male Membrane Glycoproteins - metabolism Mice, Inbred C57BL MPTP Nerve Degeneration - chemically induced Nerve Degeneration - drug therapy Nerve Degeneration - pathology Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Oxidopamine Parkinsonian Disorders - chemically induced Parkinsonian Disorders - drug therapy Parkinsonian Disorders - pathology Parkinson’s disease Phosphorylation Protein-Tyrosine Kinases - metabolism Rats, Sprague-Dawley Receptor, trkB
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