Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging
Functional nanocarriers capable of transporting high drug contents without premature leakage and to controllably deliver several drugs are needed for better cancer treatments. To address this clinical need, gold cluster bovine serum albumin (AuNC@BSA) nanogates were engineered on mesoporous silica n...
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| Veröffentlicht in: | Journal of controlled release 2016-05, Vol.229, p.183-191 |
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| creator | Croissant, Jonas G. Zhang, Dingyuan Alsaiari, Shahad Lu, Jie Deng, Lin Tamanoi, Fuyuhiko AlMalik, Abdulaziz M. Zink, Jeffrey I. Khashab, Niveen M. |
| description | Functional nanocarriers capable of transporting high drug contents without premature leakage and to controllably deliver several drugs are needed for better cancer treatments. To address this clinical need, gold cluster bovine serum albumin (AuNC@BSA) nanogates were engineered on mesoporous silica nanoparticles (MSN) for high drug loadings and co-delivery of two different anticancer drugs. The first drug, gemcitabine (GEM, 40wt%), was loaded in positively-charged ammonium-functionalized MSN (MSN-NH3+). The second drug, doxorubicin (DOX, 32wt%), was bound with negatively-charged AuNC@BSA electrostatically-attached onto MSN-NH3+, affording highly loaded pH-responsive MSN-AuNC@BSA nanocarriers. The co-delivery of DOX and GEM was achieved for the first time via an inorganic nanocarrier, possessing a zero-premature leakage behavior as well as drug loading capacities seven times higher than polymersome NPs. Besides, unlike the majority of strategies used to cap the pores of MSN, AuNC@BSA nanogates are biotools and were applied for targeted red nuclear staining and in-vivo tumor imaging. The straightforward non-covalent combination of MSN and gold-protein cluster bioconjugates thus leads to a simple, yet multifunctional nanotheranostic for the next generation of cancer treatments.
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| doi_str_mv | 10.1016/j.jconrel.2016.03.030 |
| format | Article |
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[Display omitted]</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/j.jconrel.2016.03.030</identifier><identifier>PMID: 27016140</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject><![CDATA[A549 Cells ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - chemistry ; Bovine serum albumin ; Cancer ; Cell Line ; Deoxycytidine - administration & dosage ; Deoxycytidine - analogs & derivatives ; Deoxycytidine - chemistry ; Doxorubicin - administration & dosage ; Doxorubicin - chemistry ; Drug Carriers - administration & dosage ; Drug Carriers - chemistry ; Drug Liberation ; Gold - administration & dosage ; Gold - chemistry ; Gold nanoclusters ; Humans ; Mesoporous silica nanoparticles ; Multi-drug delivery ; Nanocomposites - administration & dosage ; Nanocomposites - chemistry ; Nanoparticles - administration & dosage ; Nanoparticles - chemistry ; Neoplasms - diagnostic imaging ; Neoplasms - drug therapy ; Porosity ; Serum Albumin, Bovine - administration & dosage ; Serum Albumin, Bovine - chemistry ; Silicon Dioxide - administration & dosage ; Silicon Dioxide - chemistry]]></subject><ispartof>Journal of controlled release, 2016-05, Vol.229, p.183-191</ispartof><rights>2016</rights><rights>Copyright © 2016. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-ed92bcfcb295c63ec1f2b65c7a8e72262a070d2b940bbba79ef16b1aeb3be273</citedby><cites>FETCH-LOGICAL-c501t-ed92bcfcb295c63ec1f2b65c7a8e72262a070d2b940bbba79ef16b1aeb3be273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S016836591630164X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27016140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Croissant, Jonas G.</creatorcontrib><creatorcontrib>Zhang, Dingyuan</creatorcontrib><creatorcontrib>Alsaiari, Shahad</creatorcontrib><creatorcontrib>Lu, Jie</creatorcontrib><creatorcontrib>Deng, Lin</creatorcontrib><creatorcontrib>Tamanoi, Fuyuhiko</creatorcontrib><creatorcontrib>AlMalik, Abdulaziz M.</creatorcontrib><creatorcontrib>Zink, Jeffrey I.</creatorcontrib><creatorcontrib>Khashab, Niveen M.</creatorcontrib><title>Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>Functional nanocarriers capable of transporting high drug contents without premature leakage and to controllably deliver several drugs are needed for better cancer treatments. To address this clinical need, gold cluster bovine serum albumin (AuNC@BSA) nanogates were engineered on mesoporous silica nanoparticles (MSN) for high drug loadings and co-delivery of two different anticancer drugs. The first drug, gemcitabine (GEM, 40wt%), was loaded in positively-charged ammonium-functionalized MSN (MSN-NH3+). The second drug, doxorubicin (DOX, 32wt%), was bound with negatively-charged AuNC@BSA electrostatically-attached onto MSN-NH3+, affording highly loaded pH-responsive MSN-AuNC@BSA nanocarriers. The co-delivery of DOX and GEM was achieved for the first time via an inorganic nanocarrier, possessing a zero-premature leakage behavior as well as drug loading capacities seven times higher than polymersome NPs. Besides, unlike the majority of strategies used to cap the pores of MSN, AuNC@BSA nanogates are biotools and were applied for targeted red nuclear staining and in-vivo tumor imaging. The straightforward non-covalent combination of MSN and gold-protein cluster bioconjugates thus leads to a simple, yet multifunctional nanotheranostic for the next generation of cancer treatments.
[Display omitted]</description><subject>A549 Cells</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Bovine serum albumin</subject><subject>Cancer</subject><subject>Cell Line</subject><subject>Deoxycytidine - administration & dosage</subject><subject>Deoxycytidine - analogs & derivatives</subject><subject>Deoxycytidine - chemistry</subject><subject>Doxorubicin - administration & dosage</subject><subject>Doxorubicin - chemistry</subject><subject>Drug Carriers - administration & dosage</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Liberation</subject><subject>Gold - administration & dosage</subject><subject>Gold - chemistry</subject><subject>Gold nanoclusters</subject><subject>Humans</subject><subject>Mesoporous silica nanoparticles</subject><subject>Multi-drug delivery</subject><subject>Nanocomposites - administration & dosage</subject><subject>Nanocomposites - chemistry</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - chemistry</subject><subject>Neoplasms - diagnostic imaging</subject><subject>Neoplasms - drug therapy</subject><subject>Porosity</subject><subject>Serum Albumin, Bovine - administration & dosage</subject><subject>Serum Albumin, Bovine - chemistry</subject><subject>Silicon Dioxide - administration & dosage</subject><subject>Silicon Dioxide - chemistry</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV1rFDEUhoNY7Fr9CUouvehsk8xHdq5EilWhYC96H5KTM9MsmWRMZhb7Y_yvZtnVW4UDIZznPV8vIe8423LGu5v9dg8xJPRbUb5bVpdgL8iG72RdNX3fviSbkthVddf2l-R1znvGWFs38hW5FLKkeMM25NdDigu6UI3RWwp-zQumXIGeZ7R0whznmOKaaXbegaZBhzjrtDjwmOkQE31y4xO1aR2pj9q6MF5TvS4xxOkoG3ECt2jjAt7Y-DOm1ThwgUKsLHp3wPRc-GBpGeHgDpEu61SKukmPpdQbcjFon_Ht-b0ij3efH2-_Vvffv3y7_XRfQcv4UqHthYEBjOhb6GoEPgjTtSD1DqUQndBMMitM3zBjjJY9DrwzXKOpDQpZX5EPp7Jzij9WzIuaXAb0XgcsSygue9bXx-v9B7prmk7Iri1oe0IhxZwTDmpOZa_0rDhTRw_VXp09VEcPFatLsKJ7f26xmgntX9Uf0wrw8QRgOcnBYVIZHAZA6xLComx0_2jxG0tMtR4</recordid><startdate>20160510</startdate><enddate>20160510</enddate><creator>Croissant, Jonas G.</creator><creator>Zhang, Dingyuan</creator><creator>Alsaiari, Shahad</creator><creator>Lu, Jie</creator><creator>Deng, Lin</creator><creator>Tamanoi, Fuyuhiko</creator><creator>AlMalik, Abdulaziz M.</creator><creator>Zink, Jeffrey I.</creator><creator>Khashab, Niveen M.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20160510</creationdate><title>Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging</title><author>Croissant, Jonas G. ; Zhang, Dingyuan ; Alsaiari, Shahad ; Lu, Jie ; Deng, Lin ; Tamanoi, Fuyuhiko ; AlMalik, Abdulaziz M. ; Zink, Jeffrey I. ; Khashab, Niveen M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-ed92bcfcb295c63ec1f2b65c7a8e72262a070d2b940bbba79ef16b1aeb3be273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>A549 Cells</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Bovine serum albumin</topic><topic>Cancer</topic><topic>Cell Line</topic><topic>Deoxycytidine - administration & dosage</topic><topic>Deoxycytidine - analogs & derivatives</topic><topic>Deoxycytidine - chemistry</topic><topic>Doxorubicin - administration & dosage</topic><topic>Doxorubicin - chemistry</topic><topic>Drug Carriers - administration & dosage</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Liberation</topic><topic>Gold - administration & dosage</topic><topic>Gold - chemistry</topic><topic>Gold nanoclusters</topic><topic>Humans</topic><topic>Mesoporous silica nanoparticles</topic><topic>Multi-drug delivery</topic><topic>Nanocomposites - administration & dosage</topic><topic>Nanocomposites - chemistry</topic><topic>Nanoparticles - administration & dosage</topic><topic>Nanoparticles - chemistry</topic><topic>Neoplasms - diagnostic imaging</topic><topic>Neoplasms - drug therapy</topic><topic>Porosity</topic><topic>Serum Albumin, Bovine - administration & dosage</topic><topic>Serum Albumin, Bovine - chemistry</topic><topic>Silicon Dioxide - administration & dosage</topic><topic>Silicon Dioxide - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Croissant, Jonas G.</creatorcontrib><creatorcontrib>Zhang, Dingyuan</creatorcontrib><creatorcontrib>Alsaiari, Shahad</creatorcontrib><creatorcontrib>Lu, Jie</creatorcontrib><creatorcontrib>Deng, Lin</creatorcontrib><creatorcontrib>Tamanoi, Fuyuhiko</creatorcontrib><creatorcontrib>AlMalik, Abdulaziz M.</creatorcontrib><creatorcontrib>Zink, Jeffrey I.</creatorcontrib><creatorcontrib>Khashab, Niveen M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Croissant, Jonas G.</au><au>Zhang, Dingyuan</au><au>Alsaiari, Shahad</au><au>Lu, Jie</au><au>Deng, Lin</au><au>Tamanoi, Fuyuhiko</au><au>AlMalik, Abdulaziz M.</au><au>Zink, Jeffrey I.</au><au>Khashab, Niveen M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2016-05-10</date><risdate>2016</risdate><volume>229</volume><spage>183</spage><epage>191</epage><pages>183-191</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><abstract>Functional nanocarriers capable of transporting high drug contents without premature leakage and to controllably deliver several drugs are needed for better cancer treatments. To address this clinical need, gold cluster bovine serum albumin (AuNC@BSA) nanogates were engineered on mesoporous silica nanoparticles (MSN) for high drug loadings and co-delivery of two different anticancer drugs. The first drug, gemcitabine (GEM, 40wt%), was loaded in positively-charged ammonium-functionalized MSN (MSN-NH3+). The second drug, doxorubicin (DOX, 32wt%), was bound with negatively-charged AuNC@BSA electrostatically-attached onto MSN-NH3+, affording highly loaded pH-responsive MSN-AuNC@BSA nanocarriers. The co-delivery of DOX and GEM was achieved for the first time via an inorganic nanocarrier, possessing a zero-premature leakage behavior as well as drug loading capacities seven times higher than polymersome NPs. Besides, unlike the majority of strategies used to cap the pores of MSN, AuNC@BSA nanogates are biotools and were applied for targeted red nuclear staining and in-vivo tumor imaging. The straightforward non-covalent combination of MSN and gold-protein cluster bioconjugates thus leads to a simple, yet multifunctional nanotheranostic for the next generation of cancer treatments.
[Display omitted]</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27016140</pmid><doi>10.1016/j.jconrel.2016.03.030</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-3659 |
| ispartof | Journal of controlled release, 2016-05, Vol.229, p.183-191 |
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| subjects | A549 Cells Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Bovine serum albumin Cancer Cell Line Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Deoxycytidine - chemistry Doxorubicin - administration & dosage Doxorubicin - chemistry Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Liberation Gold - administration & dosage Gold - chemistry Gold nanoclusters Humans Mesoporous silica nanoparticles Multi-drug delivery Nanocomposites - administration & dosage Nanocomposites - chemistry Nanoparticles - administration & dosage Nanoparticles - chemistry Neoplasms - diagnostic imaging Neoplasms - drug therapy Porosity Serum Albumin, Bovine - administration & dosage Serum Albumin, Bovine - chemistry Silicon Dioxide - administration & dosage Silicon Dioxide - chemistry |
| title | Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging |
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